We investigate nucleon decays to light invisible fermion mediated by the coloured scalar S1 = ( 3, 1, −2/3) and compare them with the results coming from the mediation of S1 = ( 3, 1, 1/3). In the case of S1 = ( 3, 1, −2/3) up-like quarks couple to the invisible fermion, while in the case of S1 = ( 3, 1, 1/3) the down-like quarks couple to the invisible fermion. For the mass of invisible fermion smaller than the mass mp − mK , proton (neutron) can decay to K and invisible fermion and the masses of S1 and S1 are in the region ∼ 10 15 GeV. The decays of nucleons to pions and invisible fermion can occur at the tree-level, but in the case of S1 they come from dimension-9 operator and are therefore suppressed by several orders of magnitude compared to the decays into kaons. For the invisible fermion mass in the range (937.8 MeV, 938.8 MeV), decay of neutron n → χγ induced by S1 is possible at the loop level, while the proton remains stable. The branching ratio of such decay is ≤ 10 −6 , which does not explain neutron decay anomaly, but is in agreement with the Borexino experiment bound. We comment on low-energy processes with the nucleon-like mass of χ in the final state as Λ → χγ and heavy hadron decays to invisibles.