We consider effects of coloured scalar mediators in decays c → u invisibles. In particular, in these processes, as invisibles, we consider massive right-handed fermions. The coloured scalar S1 ≡ ( 3, 1, −2/3), due to its coupling to weak singlets up-quarks and invisible right-handed fermions (χ), is particularly interesting. Then, we consider R2 ≡ ( 3, 2, 1/6), which as a weak doublet is a subject of severe low-energy constraints. The χ mass is considered in the range (mK − mπ)/2 ≤ mχ ≤ (mD − mπ)/2. We determine branching ratios for D → χ χ, D → χ χγ and D → πχχ for several χ masses, using most constraining bounds. For S1, the most constraining is D 0 − D0 mixing, while in the case of R2 the strongest constraint comes from B → K / E. We find in decays mediated by S1 that branching ratios can be B(D → χ χ) < 10 −8 for mχ = 0.8 GeV, B(D → χ χγ) ∼ 10 −8 for mχ = 0.18 GeV, while B(D + → π + χ χ) can reach ∼ 10 −8 for mχ = 0.18 GeV. In the case of R2 these decay rates are very suppressed. We find that future tau-charm factories and Belle II experiments offer good opportunities to search for such processes. Both S1 and R2 might have masses within LHC reach.