Darier's Disease

Medansky, Roland S.

doi:10.1001/archderm.1961.01580150128021

Cited by 29 publications

(6 citation statements)

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“…There are reports in literature of association of the disease with increased psychiatric morbidity such as depression, suicidal ideation and mood disorders. 6 …”

Section: Discussionmentioning

confidence: 99%

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Severe Darier's disease in a psychiatric patient

Yang¹,

Lopes

Pereira³

et al. 2015

An. Bras. Dermatol.

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Darier’s disease is characterized by dense keratotic lesions in the seborrheic areas of the body such as scalp, forehead, nasolabial folds, trunk and inguinal region. It is a rare genodermatosis, an autosomal dominant inherited disease that may be associated with neuropsichiatric disorders. It is caused by ATPA2 gene mutation, presenting cutaneous and dermatologic expressions. Psychiatric symptoms are depression, suicidal attempts, and bipolar affective disorder. We report a case of Darier’s disease in a 48-year-old female patient presenting severe cutaneous and psychiatric manifestations.

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“…There are reports in literature of association of the disease with increased psychiatric morbidity such as depression, suicidal ideation and mood disorders. 6 …”

Section: Discussionmentioning

confidence: 99%

“…Mood disorders, including bipolar disorder, major depression, suicide ideation and suicide attempts have been reported with high prevalence among individuals with DD. 1 , 6 The most commonly observed neuropsychiatric disease in patients with DD in a series of case reports was major depression. 7 …”

Section: Discussionmentioning

confidence: 99%

Severe Darier's disease in a psychiatric patient

Yang¹,

Lopes

Pereira³

et al. 2015

An. Bras. Dermatol.

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“…DD appears in association with an increased prevalence of neuropsychiatric disorders including mental retardation, epilepsy, schizophrenia, bipolar disorder, and sociopathic behaviour [4, 10, 11]. The majority of DD patients have no neuropsychiatric problems.…”

Section: Discussionmentioning

confidence: 99%

“…In the study of Gordon-Smith et al, the IQ level of DD patients was found to be indifferent to the general population [20]. However, in a study limited to just a few cases, the IQ of 2 of the 5 patients was detected to be below the average [10]. Mental retardation has been reported in some families.…”

Section: Discussionmentioning

confidence: 99%

Cooccurrence of Darier’s Disease and Epilepsy: A Pediatric Case Report and Review of the Literature

Çelik

Dönmezer

et al. 2014

Case Reports in Pediatrics

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Darier's disease is a skin disorder characterized by multiple eruptions of hyperkeratosis or crusted papules at seborrheic areas with histologic acantholysis and dyskeratosis. It is caused by mutations in a single gene, being ATP2A2 and that is expressed in the skin and brain. The cooccurrence of various neurologic and psychiatric diseases with Darier's disease has been reported frequently in literature. They include mood disorders, epilepsy, encephalopathy, and schizophrenia. In this study, we report a pediatric case with the cooccurrence of Darier's disease and epilepsy. We also revised current English literature on this topic.

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“…The impression of many clinicians that patients with Darier's disease are mentally abnormal is not new. Medansky and Woloshin (1961) suggest the hypothesis of a combination of psychosocial factors coupled with organic brain defect which lowers the affected individual's adaptive responses. There might be an organic brain defect stemming from the intrinsic pathologic process which heretofore has only been recognized on the skin.…”

Section: Eollicularismentioning

confidence: 99%

Psychocutaneous Medicine: Present Status and Trends of Inquiry

Obermayer

1962

Australas J Dermatol

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ANT investigator in a narrow field should, every few years-^half a decade seems a suitable interval-pause, sit back, and try to assess objectively the status of his chosen specialty.In 1955, I was invited by the editors of " Excerpta Medica " to contribute to its Milestones in Dermatology on the subject of psycho cutaneous medicine. I said then, " The influence of psychic and emotional factors on certain inflammatory dermatoses is acknowledged by most investigators. Considerable divergence of opinion exists, however, as to the range of that influence and as to the mechanism by which an emotional impulse gives rise to a cutaneous symptom." That divergence still exists.Moreover, we must admit that the ultimate goal of our labour, the closure of the gap between mind and body by demonstrating the exact mechanism by which our emotional stimulus turns into a somatic symptom has so far eluded us. The old controversy, however, whether mind or body plays the crucial role, no longer goes on. It is now a question of the best explanation of the interrelationship.Considerable progress has been made by the various methods of approach used in the study of psychocutaneous medicine, namely : psychologic, neurophysiologic and biochemical research, studies in allergy, genetics and the application of social psychiatry. We shall see that research in aU of these fields converges on one central theme: no single branch of science can find the whole answer independently of the others. PSYCHOLOGIC EESEARCH.Psychologic research, undertaken on both conscious (superflcial) and unconscious (deep) levels has continued to reveal data of importance.My^ co-workers and I (1957) have continued our research on patients with disseminated neurodermatitis. But instead of following the well-trodden path of general psychologic study, we have endeavoured to define minutely the specific emotional attitudes which are signiflcantly related to exacerbations of the dermatosis. We believe that our method has succeeded in elucidating the type of emotional illness these patients have.It is a psychosis sine psychosi or, in other words, a highly specialized reaction resembling psychosis, crises acted out in the skin without otherwise losing contact with reality. By this we do not mean that the patient is deranged. We mean that he responds to the world with inappropriate patterns of reaction, physiologic and psychologic, incorporated during the infant developmental period of life, which interfere with normal reactions. We are not alone in the demonstration of a mechanism in psychocutaneous reactions which is closer to psychosis rather

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Darier's Disease

Cited by 29 publications

References 3 publications

Severe Darier's disease in a psychiatric patient

Severe Darier's disease in a psychiatric patient

Cooccurrence of Darier’s Disease and Epilepsy: A Pediatric Case Report and Review of the Literature

Psychocutaneous Medicine: Present Status and Trends of Inquiry

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