Darier’s disease is characterized by dense keratotic lesions in the seborrheic areas
of the body such as scalp, forehead, nasolabial folds, trunk and inguinal region. It
is a rare genodermatosis, an autosomal dominant inherited disease that may be
associated with neuropsichiatric disorders. It is caused by ATPA2 gene mutation,
presenting cutaneous and dermatologic expressions. Psychiatric symptoms are
depression, suicidal attempts, and bipolar affective disorder. We report a case of
Darier’s disease in a 48-year-old female patient presenting severe cutaneous and
psychiatric manifestations.
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