Daptomycin combinations as alternative therapies in experimental foreign-body infection caused by meticillin-susceptible Staphylococcus aureus

Haj, Cristina El; Murillo, Óscar; Ribera, Alba; Vivas, Mireia; García-Somoza, Dolores; Tubau, Fé; Cabellos, Carmen; Cabo, J.; Ariza, Javier

doi:10.1016/j.ijantimicag.2015.04.004

Cited by 11 publications

(4 citation statements)

References 27 publications

(60 reference statements)

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“…Examples of recent studies include the combination of clarithromycin and daptomycin 15 and rifampicin and daptomycin. 16 Both studies revealed potentiated antimicrobial efficacy against different strains of S. aureus . However, combining antibiotics may also make their adverse effects more pronounced.…”

Section: Introductionmentioning

confidence: 97%

Synergistic antibacterial effects of herbal extracts and antibiotics on methicillin-resistant Staphylococcus aureus: A computational and experimental study

Kuok

Hoi

et al. 2017

Exp Biol Med (Maywood)

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Antibiotic resistant is a well-known threat to global health and methicillin-resistant Staphylococcus aureus is one of the most significant ones. These resistant bacteria kill thousands of people every year and therefore a new effective antimicrobial treatment is necessary. This study identified the herbs and their associated bioactive ingredients that can potential the effects of current antibiotics. These herbs have long history of human usage in China and have well-defined monograph in the Chinese Pharmacopeia. These indicate their relatively high clinical safety and may have a quicker drug development process than that of a new novel antibiotic. Based on the results of this study, the authors will perform further in vitro and animal studies, aiming to accumulate significant data for the application of clinical trial. AbstractAntibiotic resistance has become a serious global concern, and the discovery of antimicrobial herbal constituents may provide valuable solutions to overcome the problem. In this study, the effects of therapies combining antibiotics and four medicinal herbs on methicillinresistant Staphylococcus aureus (MRSA) were investigated. Specifically, the synergistic effects of Magnolia officinalis, Verbena officinalis, Momordica charantia, and Daphne genkwa in combination with oxacillin or gentamicin against methicillin-resistant (ATCC43300) and methicillin-susceptible (ATCC25923) S. aureus were examined. In vitro susceptibility and synergistic testing were performed to measure the minimum inhibitory concentration and fractional inhibitory concentration (FIC) index of the antibiotics and medicinal herbs against MRSA and methicillin-susceptible S. aureus. To identify the active constituents in producing these synergistic effects, in silico molecular docking was used to investigate the binding affinities of 139 constituents of the four herbs to the two common MRSA inhibitory targets, penicillin binding proteins 2a (PBP2a) and 4 (PBP4). The physicochemical and absorption, distribution, metabolism, and excretion properties and drug safety profiles of these compounds were also analyzed. D. genkwa extract potentiated the antibacterial effects of oxacillin against MRSA, as indicated by an FIC index value of 0.375. M. officinalis and V. officinalis produced partial synergistic effects when combined with oxacillin, whereas M. charantia was found to have no beneficial effects in inhibiting MRSA. Overall, tiliroside, pinoresinol, magnatriol B, and momorcharaside B were predicted to be PBP2a or PBP4 inhibitors with good drug-like properties. This study identifies compounds that deserve further investigation with the aim of developing therapeutic agents to modulate the effect of antibiotics on MRSA.

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Section: Introductionmentioning

confidence: 97%

Synergistic antibacterial effects of herbal extracts and antibiotics on methicillin-resistant Staphylococcus aureus: A computational and experimental study

Kuok

Hoi

et al. 2017

Exp Biol Med (Maywood)

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“… 6 , 43 mainly if combined with rifampin. 44 , 45 However, reliable minimal biofilm eradication concentration (MBEC) of each antibiotic may be difficult to predict. Molina-Manso et al observed MBEC values as high as 1024 mg/L for most common antibiotics used to treat BJI.…”

Section: Discussionmentioning

confidence: 99%

Daptomycin to bone and joint infections and prosthesis joint infections: a systematic review

Telles

Cieslinski

Tuon

2019

The Brazilian Journal of Infectious Diseases

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“…As for daptomycin combination therapy, several studies have been published. For daptomycin in combination with rifampin, in vitro models show diverse results from possible antagonism in an experimental endocarditis model [47] to increased efficacy [48] and bactericidal activity in biofilm-embedded bacteria in S. aureus biofilms [49]. Increased efficacy was also shown for combination therapy in an experimental MRSA foreign-body-infection model [50].…”

Section: Daptomycin In Infective Endocarditis and Osteomyelitismentioning

confidence: 99%

New-Generation Antibiotics for Treatment of Gram-Positive Infections: A Review with Focus on Endocarditis and Osteomyelitis

Bloem

Bax

Yusuf

et al. 2021

JCM

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Infective endocarditis, osteomyelitis, and osteosynthesis-associated infections are mostly caused by Gram-positive bacteria. They are often difficult to treat and are associated with a poor prognosis. In the past 20 years, nine antibiotic drugs with predominant activity against Gram-positive bacteria have been introduced and approved by the Food and Drug Administration or the European Medicines Agency: ceftaroline, daptomycin, telavancin, dalbavancin, oritavancin, linezolid, tedizolid, delafloxacin, and omadacycline. This narrative review aims to provide an overview on these antibiotics with a special focus on their use in infective endocarditis, osteomyelitis, and osteosynthesis-associated infections. Although some of these approved antibiotics are promising, they should not be used as first- or second-line therapy, awaiting more clinical data.

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Daptomycin combinations as alternative therapies in experimental foreign-body infection caused by meticillin-susceptible Staphylococcus aureus

Cited by 11 publications

References 27 publications

Synergistic antibacterial effects of herbal extracts and antibiotics on methicillin-resistant Staphylococcus aureus: A computational and experimental study

Synergistic antibacterial effects of herbal extracts and antibiotics on methicillin-resistant Staphylococcus aureus: A computational and experimental study

Daptomycin to bone and joint infections and prosthesis joint infections: a systematic review

New-Generation Antibiotics for Treatment of Gram-Positive Infections: A Review with Focus on Endocarditis and Osteomyelitis

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