Dapsone reduced acetic acid-induced inflammatory response in rat colon tissue through inhibition of NF-kB signaling pathway

Rashidian, Amir; Rashki, Asma; Abdollahi, Alireza; Haddadi, Nazgol‐Sadat; Chamanara, Mohsen; Mumtaz, Faiza; Dehpour, Ahmad Reza

doi:10.1080/08923973.2019.1678635

Cited by 33 publications

(16 citation statements)

References 37 publications

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“…In this study water immersion restraint enhanced TNF-α, IL-1β, and NF-κB activity. In addition, it has been found that dapsone have antiin ammatory properties through down regulation of NF-kB pathway in a rat model of colitis [47]. The present study demonstrated that dapsone reduced mucosal injury of the stomach tissue and J score mean in a dose dependent manner in stress erosion.…”

Section: Discussionsupporting

confidence: 64%

Dapsone Attenuates the Severity of Gastric Erosion Induced by Ethanol; Stress; and Indomethacin in Rats: A Pharmacological Approach

Sheibani

Nezamoleslami

Rahimi

et al. 2020

Preprint

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Background: Dapsone, as an antimicrobial compound, has shown strong anti-inflammatory properties in clinical and experimental studies. Inflammation in stomach mocusa produce gastric erosion. Several factors contribute to the development of gastric erosions, including corticosteroids and nonsteroidal anti-inflammatory drugs (NSAIDs), alcohol, and stress. The aim of this study, therefore, was to evaluate the effects of dapsone against gastric erosions-induced by alcohol, stress, or indomethacin in rat.Methods: Gastric damage was induced in male rats in different three experimental models including ethanol (5 ml/kg, p.o.)-, water-immersion stress-, and indomethacin (30 mg/kg, p.o.)- induced gastric injury. Macroscopic lesion scores (the J- score), inflammatory cytokines levels, NF-κB protein expression, MPO activity, and histopathological evaluation were assessed. Results: Induction of erosion in gastric mocusal led to a significant increase in J-score as an index of macroscopic parameter, tumor necrosis factor-alpha (TNF-α), interleukin-1beta (IL-1β) as biochemical markers, NF-κB and myeloperoxidase (a marker of neutrophil activation, as well microscopic deterioration. Dapsone reduced the tissue injuries and erosion area, serum levels of inflammatory cytokines, the expression of NF-κB and tissue concentration of myeloperoxidase (a marker of neutrophil activation) in all three experimental groups. Furthermore, the histopathological studies revealed the reduction of damages in dapsone treated animals.Conclusions: To conclude, dapsone exhibits significant gastro-protective effects against the development of experimental gastric erosions in rats which seems to be related to its anti-inflammatory properties.

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Section: Discussionsupporting

confidence: 64%

Dapsone Attenuates the Severity of Gastric Erosion Induced by Ethanol; Stress; and Indomethacin in Rats: A Pharmacological Approach

Sheibani

Nezamoleslami

Rahimi

et al. 2020

Preprint

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“…TLR4, one of the best characterized pattern recognition receptors, is activated by LPS, leading to the activation of NF-κB and subsequently inducing the production of proinflammatory mediators. Recently, many studies have indicated that NF-κB is a key factor in inflammatory gene expression [37][38][39]. Under normal conditions, NF-κB binds with IκB to form an inactivation complex.…”

Section: Discussionmentioning

confidence: 99%

Sinapic Acid Alleviated Inflammation-Induced Intestinal Epithelial Barrier Dysfunction in Lipopolysaccharide- (LPS-) Treated Caco-2 Cells

Lan

Zhang

et al. 2021

Mediators of Inflammation

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The integrity and permeability of the intestinal epithelial barrier are important indicators of intestinal health. Impaired intestinal epithelial barrier function and increased intestinal permeability are closely linked to the onset and progression of various intestinal diseases. Sinapic acid (SA) is a phenolic acid that has anti-inflammatory, antihyperglycemic, and antioxidant activities; meanwhile, it is also effective in the protection of inflammatory bowel disease (IBD), but the specific mechanisms remain unclear. Here, we evaluated the anti-inflammatory of SA and investigated its potential therapeutic activity in LPS-induced intestinal epithelial barrier and tight junction (TJ) protein dysfunction. SA improved cell viability; attenuated epithelial permeability; restored the protein and mRNA expression of claudin-1, ZO-1, and occludin; and reversed the redistribution of the ZO-1 and claudin-1 proteins in LPS-treated Caco-2 cells. Moreover, SA reduced the inflammatory response by downregulating the activation of the TLR4/NF-κB pathway and attenuated LPS-induced intestinal barrier dysfunction by decreasing the activation of the MLCK/MLC pathway. This study demonstrated that SA has strong anti-inflammatory activity and can alleviate the occurrence of high intercellular permeability in Caco-2 cells exposed to LPS.

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“…Interestingly, DDS modulated the inflammatory cells, including granulocytes in LPS-treated BMs, by inducing cell death. DDS decreased the mitochondrial membrane potential of LPS-treated BMs [ 88 ] and reduced acetic acid-induced inflammatory response in rat colon tissue through the inhibition of the NF-kB signaling pathway [ 89 ]. DDS has an effect on mRNA expression and the production of cytokines in lipopolysaccharide-stimulated peripheral blood mononuclear cells.…”

Section: Discussionmentioning

confidence: 99%

4,4′-Diaminodiphenyl Sulfone (DDS) as an Inflammasome Competitor

Lee

Sohn

et al. 2020

IJMS

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The aim of this study is to examine the use of an inflammasome competitor as a preventative agent. Coronaviruses have zoonotic potential due to the adaptability of their S protein to bind receptors of other species, most notably demonstrated by SARS-CoV. The binding of SARS-CoV-2 to TLR (Toll-like receptor) causes the release of pro-IL-1β, which is cleaved by caspase-1, followed by the formation and activation of the inflammasome, which is a mediator of lung inflammation, fever, and fibrosis. The NLRP3 (NACHT, LRR and PYD domains-containing protein 3) inflammasome is implicated in a variety of human diseases including Alzheimer’s disease (AD), prion diseases, type 2 diabetes, and numerous infectious diseases. By examining the use of 4,4′-diaminodiphenyl sulfone (DDS) in the treatment of patients with Hansen’s disease, also diagnosed as Alzheimer’s disease, this study demonstrates the diverse mechanisms involved in the activation of inflammasomes. TLRs, due to genetic polymorphisms, can alter the immune response to a wide variety of microbial ligands, including viruses. In particular, TLR2Arg677Trp was reported to be exclusively present in Korean patients with lepromatous leprosy (LL). Previously, mutation of the intracellular domain of TLR2 has demonstrated its role in determining the susceptibility to LL, though LL was successfully treated using a combination of DDS with rifampicin and clofazimine. Of the three tested antibiotics, DDS was effective in the molecular regulation of NLRP3 inflammasome activators that are important in mild cognitive impairment (MCI), Parkinson’s disease (PD), and AD. The specific targeting of NLRP3 itself or up-/downstream factors of the NLRP3 inflammasome by DDS may be responsible for its observed preventive effects, functioning as a competitor.

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Dapsone reduced acetic acid-induced inflammatory response in rat colon tissue through inhibition of NF-kB signaling pathway

Cited by 33 publications

References 37 publications

Dapsone Attenuates the Severity of Gastric Erosion Induced by Ethanol; Stress; and Indomethacin in Rats: A Pharmacological Approach

Dapsone Attenuates the Severity of Gastric Erosion Induced by Ethanol; Stress; and Indomethacin in Rats: A Pharmacological Approach

Sinapic Acid Alleviated Inflammation-Induced Intestinal Epithelial Barrier Dysfunction in Lipopolysaccharide- (LPS-) Treated Caco-2 Cells

4,4′-Diaminodiphenyl Sulfone (DDS) as an Inflammasome Competitor

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