1981
DOI: 10.1001/archderm.117.1.38
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Dapsone hypersensitivity. The sulfone syndrome revisited

Abstract: A hypersensitivity reaction to low-dose (50-mg), short-term dapsone administration developed in a 16-year-old girl. The reaction included fever, malaise, dermatitis, jaundice with hepatic dysfunction, lymphadenopathy, and hemolytic anemia. Physicians should be familiar with this "sulfone syndrome," an uncommon, potentially serious, side effect of dapsone therapy.

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Cited by 29 publications
(18 citation statements)
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“…Later reports consider that the syndrome is due to an idiosyncratic hypersensitivity reaction to dapsone. I , 4,6,9 Eight of the 20 patients reported since 1949 received dapsone for conditions other than leprosy, and, including the 2 present cases, only 36% developed the complete clinical complex of rash, fe ver, jaundice and lymphadenopathy, which is in keeping with the observation of one study1 6 that the fu ll syndrome is rare. Where it occurred, fever was generally high and lasted for one week or more.…”
Section: Commentsupporting
confidence: 85%
“…Later reports consider that the syndrome is due to an idiosyncratic hypersensitivity reaction to dapsone. I , 4,6,9 Eight of the 20 patients reported since 1949 received dapsone for conditions other than leprosy, and, including the 2 present cases, only 36% developed the complete clinical complex of rash, fe ver, jaundice and lymphadenopathy, which is in keeping with the observation of one study1 6 that the fu ll syndrome is rare. Where it occurred, fever was generally high and lasted for one week or more.…”
Section: Commentsupporting
confidence: 85%
“…The pathogenesis of the sulfone syndrome is not well established but seems to be related to a delayed hypersensitivity reaction with eosinophilia [1,2]. Hepatic injury occurs in the majority of patients and can be both cholestatic and hepatocellular in nature.…”
Section: Discussionmentioning
confidence: 99%
“…It has recently been studied for PCP prophylaxis in the hematopoietic stem cell transplant (HSCT) setting by Boeckh et al in patients who could not tolerate trimethoprim-sulfamethoxazole (TMP-SMX) [1]. Dapsone is a diaminodiphenylsulfone with indications for the treatment of leprosy, dermatitis herpetiformis and as a second line agent in the treatment and prevention against Pneumocystis carinii pneumonia (PCP) [2]. With the increase in number of immunocompromised patients, dapsone use for PCP prophylaxis is on the rise [2].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…It is antibacterial drug used in the treatment of Mycobacterium leprae infection (leprosy), and malaria [1, 2]. It is official in BP and USP [3, 4]:…”
Section: Introductionmentioning
confidence: 99%