Dapsone and rheumatoid vasculitis leg ulcerations

Bernard, Philippe; Arnaud, Marie; Trèves, R.; Bonnetblanc, Jean-Marie

doi:10.1016/s0190-9622(88)80049-5

“…Systemic corticosteroid therapy was tried, but it was not effective. We found some reports that dapsone was an effective drug for DLE and refractory leg ulcers (4)(5)(6). As our patient suffered from LEP with refractory ulcers, we tried dapsone; the result was that the ulcers on the LEP lesion healed, leaving cup-shaped depressed scars.…”

Section: Discussionmentioning

confidence: 86%

Lupus Erythematosus Profundus

Yamada

¹

,

Dekio

²

,

Jidoi

³

et al. 1989

The Journal of Dermatology

View full text Add to dashboard Cite

show abstract

“…Commentary: There are four case series regarding the usefulness of DDS for treating rheumatoid vasculitis‐associated skin ulcers; thus, the evidence level is V and the recommendation level is 1C. The administration of DDS should be evaluated when a sufficient response to steroid or cyclophosphamide pulse therapy cannot be obtained in patients with a favorable prognosis such as those in whom leukocytoclastic vasculitis is histopathologically detected in the dermis, histopathological changes resembling those in polyarteritis nodosa are seen and the presence of arteritis is clinically suspected. Bernard et al . reported two patients in whom DDS effectively controlled intractable rheumatoid vasculitis‐associated skin ulcers.…”

Section: Cq25: Is Dds Useful For Rheumatoid Vasculitis‐associated Skimentioning

confidence: 99%

Wound, pressure ulcer and burn guidelines – 4: Guidelines for the management of connective tissue disease/vasculitis‐associated skin ulcers

Fujimoto

¹

,

Asai

²

,

Asano

³

et al. 2020

The Journal of Dermatology

View full text Add to dashboard Cite

The Japanese Dermatological Association prepared guidelines focused on the treatment of skin ulcers associated with connective tissue disease/vasculitis practical in clinical settings of dermatological care. Skin ulcers associated with connective tissue diseases or vasculitis occur on the background of a wide variety of diseases including, typically, systemic sclerosis but also systemic lupus erythematosus (SLE), dermatomyositis, rheumatoid arthritis (RA), various vasculitides and antiphospholipid antibody syndrome (APS). Therefore, in preparing the present guidelines, we considered diagnostic/therapeutic approaches appropriate for each of these disorders to be necessary and developed algorithms and clinical questions for systemic sclerosis, SLE, dermatomyositis, RA, vasculitis and APS.

show abstract

“…There are four case series studies regarding the usefulness of dapsone for the treatment of skin ulcers associated with rheumatoid vasculitis, [99][100][101][102] and the evidence level is V. The administration of dapsone should be evaluated when a sufficient response to steroid or cyclophosphamide pulse therapy cannot be obtained in patients with a favorable prognosis such as those in whom leukocytoclastic vasculitis is histopathologically detected in the dermis, patients showing histopathological changes resembling those in polyarteritis nodosa and patients in whom the presence of arteritis is clinically suspected. Bernard et al 99 reported two patients in whom dapsone was effective for the control of intractable skin ulcers asso-ciated with rheumatoid vasculitis. In one patient, dapsone was administrated additionally at 100 mg/day for intractable skin ulcers, resolution was observed 24 days after the beginning of treatment, and no recurrence of ulcer was observed even after the discontinuation of dapsone administration.…”

Section: Cq19: Is Dapsone Useful For the Control Of Skin Ulcers Assocmentioning

confidence: 99%

The wound/burn guidelines – 4: Guidelines for the management of skin ulcers associated with connective tissue disease/vasculitis

Fujimoto

¹

,

Asano

²

,

Ishii

³

et al. 2016

The Journal of Dermatology

View full text Add to dashboard Cite

The Japanese Dermatological Association prepared guidelines focused on the treatment of skin ulcers associated with connective tissue disease/vasculitis practical in clinical settings of dermatological care. Skin ulcers associated with connective tissue diseases or vasculitis occur on the background of a wide variety of diseases including, typically, systemic sclerosis but also systemic lupus erythematosus (SLE), dermatomyositis, rheumatoid arthritis (RA), various vasculitides and antiphospholipid antibody syndrome (APS). Therefore, in preparing the present guidelines, we considered diagnostic/therapeutic approaches appropriate for each of these disorders to be necessary and developed algorithms and clinical questions for systemic sclerosis, SLE, dermatomyositis, RA, vasculitis and APS.Key words: antiphospholipid antibody syndrome, dermatomyositis, rheumatoid arthritis, systemic lupus erythematosus, vasculitis.Correspondence: Hironobu Ihn, M.D., Ph.D., Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan. Email: ihn-der@kumamoto-u.ac.jp This is the secondary English version of the original Japanese manuscript for The wound/burn guidelines -4: Guidelines for the management of skin ulcers associated with connective tissue disease/vasculitis published in

show abstract

Dapsone and rheumatoid vasculitis leg ulcerations

Cited by 17 publications

References 9 publications

Lupus Erythematosus Profundus

Lupus Erythematosus Profundus

Wound, pressure ulcer and burn guidelines – 4: Guidelines for the management of connective tissue disease/vasculitis‐associated skin ulcers

The wound/burn guidelines – 4: Guidelines for the management of skin ulcers associated with connective tissue disease/vasculitis

Contact Info

Product

Resources

About