Danofloxacin (Advocin™) reduces the spread of contagious bovine pleuropneumonia to healthy in-contact cattle

Huebschle, Otto J.B.; Ayling, Roger D.; Godinho, Kevin; Lukhele, Obed Mooki; Tjipura-Zaire, Georgina; Rowan, T.G.; Nicholas, R. A. J.

doi:10.1016/j.rvsc.2006.02.005

Cited by 32 publications

(35 citation statements)

References 10 publications

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“…This is within the mortality rates expected in a CBPP outbreak where it has been shown that an outbreak usually causes mortality rates of 50 to 80% in a herd (Thomson, 2005). These results are also in agreement with studies of Huebschle et al (2006) who showed that there was no difference between danofloxacin treated and untreated groups in terms of death due to CBPP. However, this is in contrast to reports made by Nicholas et al (2012) where all the cattle that were treated using danofloxacin survived except for three that died in the first three months.…”

Section: Discussionsupporting

confidence: 92%

“…Studies by Yaya et al (2004) showed that in an experimental infection,oxytetracycline was able to reduce the losses due to CBPP but could not prevent the persistence of viable Mmm in the treated animals suggesting that treated animals could still spread the disease to susceptible animals. However, in similar studies of naturally infected cattle, Huebschle et al (2006) reported success in reducing spread of the disease in a trial using danofloxacin, but failed to reduce clinical effects. In an investigation by Niang et al (2010), it was reported that oxytetracycline failed to induce sequestra formation under experimental conditions demonstrating the probability of cure and not the evolution of the disease to chronicity to the treated group.…”

Section: Introductionmentioning

confidence: 99%

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Observations of oxytetracycline treatment effects in a contagious bovine pleuropneumonia naturally infected herd in Zambia

Muuka¹,

Songolo²,

Kabilika³

et al. 2017

J. Vet. Med. Anim. Health

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An observational study on the effects of oxytetracycline treatment on contagious bovine pleuropneumonia in a naturally infected herd of 500 cattle was conducted. A total of 68 cattle that showed pneumonia-like clinical signs were treated. Treatment was effected the moment an animal showed signs of illness. A total of 429 cattle were slaughtered after diagnosis of contagious bovine pleuropneumonia and at slaughter, 40.8% (175) had lesions compared to 59.2% (254) that did not have lesions. Out of the total cattle that were treated with oxytetracycline, 57.4% (39) died from contagious bovine pleuropneumonia over a period of 9 weeks while 42.6% (29) survived. Of the treatment group that survived, 37.9% (11) had fibrous lesions indicative of healing, while 62.1% (18) had pathological lesions consistent of active contagious bovine pleuropneumonia (CBPP). Categorisation of carcases with pathological lesions within the treatment group showed 66.7% (12) and 33.3% (6) of acute and chronic lesions, respectively. The CBPP causative agent was isolated through culture and confirmed using polymerase chain reaction (PCR). The results obtained suggest that oxytetracycline did not stop the spread or death of cattle in this particular herd with the treatment of a proportion of the herd. However, large scale field trials are needed in order to validate these findings. It is therefore recommended that any antibiotic that will be developed and advocated for use in the treatment of contagious bovine pleuropneumonia should be effective to contain spread within the herd by treating only a proportion showing signs of the disease.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Observations of oxytetracycline treatment effects in a contagious bovine pleuropneumonia naturally infected herd in Zambia

Muuka¹,

Songolo²,

Kabilika³

et al. 2017

J. Vet. Med. Anim. Health

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“…OTC has been observed to prevent death from CBPP but failed to eliminate the pathogen (Yaya et al, 2004), suggesting that disease transmission would not be prevented. In contrast, whilst danofloxacin had no obvious effect on the course of infection, it appeared to limit the spread of disease to incontact animals (Huebschle et al, 2006). These results are consistent with only partial efficacy and additional research is clearly required to identify the most appropriate antimicrobial for CBPP control and to define an optimal dosage for its deployment.…”

Section: Introductionmentioning

confidence: 67%

“…The use of antimicrobials is controversial largely because of the perception that they promote the development of chronic carriers (Provost et al, 1987) but also as a result of concerns regarding the development of resistance. As such, antimicrobials are discouraged or banned in most affected countries (Huebschle et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antimicrobial activity against Mycoplasma mycoides subsp. mycoides Small Colony using an in vitro dynamic dilution pharmacokinetic/pharmacodynamic model

Mitchell

McKellar

McKeever

2013

Journal of Medical Microbiology

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The objectives of this study were to assess the activity of oxytetracycline (OTC), danofloxacin and tulathromycin against Mycoplasma mycoides subsp. mycoides Small Colony, the causative agent of contagious bovine pleuropneumonia, in an in vitro dynamic concentration model and to determine the concentration and/or time dependence of such activity. Time-kill assays that simulated elimination of antimicrobials from the body were performed. Initial antimicrobial concentrations corresponded to various multiples of the MIC and cultures were diluted in a stepwise fashion with either drug-free or drug-containing artificial medium to mimic administration by single-release bolus or infusion, respectively. Where appropriate, data were fitted to sigmoidal E max models. OTC produced no change in mycoplasma titre from the initial inoculum size, regardless of the concentration or means of drug exposure. Both danofloxacin and tulathromycin resulted in a decrease in mycoplasma titre but neither was bactericidal (99.9 % kill) over 12 h. A greater antimycoplasmal effect, defined as the change in log 10 (c.f.u. ml ) over 12 h, was achieved when danofloxacin was administered as a single-release bolus, suggesting concentration-dependent activity, whereas the antimycoplasmal effect of tulathromycin was comparable following administration by single-release bolus or infusion, owing to its long half-life.

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“…The two remaining options are chemotherapy and vaccination campaigns. The use of chemotherapy in CBPP treatment is controversial and officially discouraged due to the risk of creating silent carriers of the disease (32), although recent antibiotic trials have shown positive effects (16,25).…”

mentioning

confidence: 99%

Protein-Specific Analysis of Humoral Immune Responses in a Clinical Trial for Vaccines against Contagious Bovine Pleuropneumonia

Hamsten

Tjipura-Zaire

Huebschle

et al. 2010

Clin Vaccine Immunol

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Danofloxacin (Advocin™) reduces the spread of contagious bovine pleuropneumonia to healthy in-contact cattle

Cited by 32 publications

References 10 publications

Observations of oxytetracycline treatment effects in a contagious bovine pleuropneumonia naturally infected herd in Zambia

Observations of oxytetracycline treatment effects in a contagious bovine pleuropneumonia naturally infected herd in Zambia

Evaluation of antimicrobial activity against Mycoplasma mycoides subsp. mycoides Small Colony using an in vitro dynamic dilution pharmacokinetic/pharmacodynamic model

Protein-Specific Analysis of Humoral Immune Responses in a Clinical Trial for Vaccines against Contagious Bovine Pleuropneumonia

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