Daño renal agudo en niños críticos: incidencia y factores de riesgo de mortalidad

Martin, Sarah E.

doi:10.5546/aap.2013.412

Cited by 4 publications

(1 citation statement)

References 29 publications

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“…Therefore, in highly complex PICU, the main characteristics described are sepsis, organ transplants, and cardiovascular surgery [10,11,13]. Sepsis is one the main causes of AKI in children and its incidence has been described between 9% and 34% [14][15][16][17]. Additionally, in medium-and low-complexity levels, hypotension, dehydration, and sepsis are the most important factors [12,18,19].…”

Section: Introductionmentioning

confidence: 99%

Acute renal failure in children. Multicenter prospective cohort study in medium-complexity intensive care units from the Colombian southeast

et al. 2020

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Background Acute kidney injury is frequent in critically ill children; however, it varies in causality and epidemiology according to the level of patient care complexity. A multicenter prospective cohort study was conducted in four medium-complexity pediatric intensive care units from the Colombian southeast aimed to estimate the clinical prognosis of patients with diagnosis of acute kidney injury. Methods We included children >28 days and <18 years of age, who were admitted with diagnosis of acute kidney injury classified by Kidney Disease Improving Global Outcomes (KDIGO), during the period from January to December 2017. Severe acute kidney injury was defined as stage 2 and stage 3 classifications. Maximum KDIGO was evaluated during the hospital stay and follow up. Length of hospital stay, use of mechanical ventilation and vasoactive drugs, use of renal replacement therapy, and mortality were assessed until discharge. Results Prevalence at admission of acute kidney injury was 5.2% (95%CI 4.3% to 6.2%). It was found that 71% of the patients had their maximum KDIGO on day one; an increment in the maximum stage of acute kidney injury increased the pediatric intensive care unit stay. Patients with maximum KDIGO 3 were associated with greater use of mechanical ventilation (47%), compared with maximum KDIGO 2 (37%) and maximum KDIGO 1 (16%). Eight

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Section: Introductionmentioning

confidence: 99%

Acute renal failure in children. Multicenter prospective cohort study in medium-complexity intensive care units from the Colombian southeast

et al. 2020

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Clinical Pharmacology Studies in Critically Ill Children

et al. 2016

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Developmental and physiological changes in children contribute to variation in drug disposition with age. Additionally, critically ill children suffer from various life-threatening conditions that can lead to pathophysiological alterations that further affect pharmacokinetics (PK). Some factors that can alter PK in this patient population include variability in tissue distribution caused by protein binding changes and fluid shifts, altered drug elimination due to organ dysfunction, and use of medical interventions that can affect drug disposition (e.g., extracorporeal membrane oxygenation and continuous renal replacement therapy). Performing clinical studies in critically ill children is challenging because there is large inter-subject variability in the severity and time course of organ dysfunction; some critical illnesses are rare, which can affect subject enrollment; and critically ill children usually have multiple organ failure, necessitating careful selection of a study design. As a result, drug dosing in critically ill children is often based on extrapolations from adults or non-critically ill children. Dedicated clinical studies in critically ill children are urgently needed to identify optimal dosing of drugs in this population. This review will summarize the effect of critical illness on pediatric PK, the challenges associated with performing studies in this vulnerable subpopulation, and the clinical PK studies performed to date for commonly used drugs.

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Evaluation of the prevalence and factors associated with acute kidney injury in a pediatric intensive care unit

Louzada

Ferreira

2021

Jornal de Pediatria

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Daño renal agudo en niños críticos: incidencia y factores de riesgo de mortalidad

Cited by 4 publications

References 29 publications

Acute renal failure in children. Multicenter prospective cohort study in medium-complexity intensive care units from the Colombian southeast

Acute renal failure in children. Multicenter prospective cohort study in medium-complexity intensive care units from the Colombian southeast

Clinical Pharmacology Studies in Critically Ill Children

Evaluation of the prevalence and factors associated with acute kidney injury in a pediatric intensive care unit

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