Danish Patients With Chronic Pancreatitis Have a Four-Fold Higher Mortality Rate Than the Danish Population

Nøjgaard, Camilla; Bendtsen, Flemming; Becker, Ulrik; Andersen, Jens Rikardt; Holst, Claus; Matzen, Peter

doi:10.1016/j.cgh.2009.12.016

Cited by 58 publications

(35 citation statements)

References 30 publications

(27 reference statements)

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“…This may be due to the fact that 24.1% developed CP during follow-up [31]; most of these patients died during follow-up; some of them died of CP alone (7.9%). In a previous study [31], we found that the mortality for patients who developed CP after AP was 2.7 times higher than the mortality in patients who did not develop CP, and 5.3-6.5 times higher than the mortality in the background population. In addition, 37% of the AP patients had a high alcohol intake and, therefore, a high risk of developing alcoholic cirrhosis, which 5.5% of the patients died from compared with 1.6% of the total Danish population.…”

Section: Causes Of Deathmentioning

confidence: 88%

“…During the follow-up, 20 surgical procedures were done in 17 individuals: subtotal pancreatectomy, pancreaticogastrostomy, pancreaticojejunostomy or pancreatic lithotomy. During the follow-up, 85 (24.1%) patients developed CP [31].…”

Section: Patient Characteristics At Initial Hospitalizationmentioning

confidence: 98%

“…The Copenhagen Pancreatitis Study (CPS) is a large prospective cohort study of patients in the Copenhagen Municipality admitted with either AP or chronic pancreatitis (CP) fulfilling specific diagnostic criteria [27,28]. The CPS has the advantages of a prospective design, large size, geographical demarcation, and a complete 30-year follow-up by means of record linkage to the Danish health registries [29].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Factors associated with long-term mortality in acute pancreatitis

Nøjgaard

Matzen

Bendtsen

et al. 2010

Scandinavian Journal of Gastroenterology

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Section: Causes Of Deathmentioning

confidence: 88%

Section: Patient Characteristics At Initial Hospitalizationmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Factors associated with long-term mortality in acute pancreatitis

Nøjgaard

Matzen

Bendtsen

et al. 2010

Scandinavian Journal of Gastroenterology

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“…In addition, patients with chronic pancreatitis constitute a high-risk group for ordinary-type pancreatic cancer [73][74][75]. Although clear evidence for testing is lacking, many patients with chronic pancreatitis lead a lifestyle associated with carcinogenic risks (alcohol drinking and/or smoking), and it is useful to perform cancer screening [65,[76][77][78][79][80][81].…”

Section: Pain Managementmentioning

confidence: 99%

Evidence-based clinical practice guidelines for chronic pancreatitis 2015

et al. 2016

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Chronic pancreatitis is considered to be an irreversible progressive chronic inflammatory disease. The etiology and pathology of chronic pancreatitis are complex; therefore, it is important to correctly understand the stage and pathology and provide appropriate treatment accordingly. The newly revised Clinical Practice Guidelines of Chronic Pancreatitis 2015 consist of four chapters, i.e., diagnosis, staging, treatment, and prognosis, and includes a total of 65 clinical questions. These guidelines have aimed at providing certain directions and clinically practical contents for the management of chronic pancreatitis, preferentially adopting clinically useful articles. These revised guidelines also refer to early chronic pancreatitis based on the Criteria for the Diagnosis of Chronic Pancreatitis 2009. They include such items as health insurance coverage of high-titer lipase preparations and extracorporeal shock wave lithotripsy, new antidiabetic drugs, and the definition of and treatment approach to pancreatic pseudocyst. The accuracy of these guidelines has been improved by examining and adopting new evidence obtained after the publication of the first edition.

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“…In contrast to AP [2], few population-based data are available for CP [3,4,5,6,7]. Population-based US estimates for CP have been reported for the city of Rochester, Minn., USA (1940–1969) [8] and, Olmsted County, Minn., USA (1977–2006) [9] as well as the number of admissions to US non-federal acute care hospitals (1988–2004) [10].…”

Section: Introductionmentioning

confidence: 99%

Hospitalizations for Chronic Pancreatitis in Allegheny County, Pennsylvania, USA

2011

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Background/Aims: Population-based estimates for chronic pancreatitis (CP) are scarce. We determined incident CP hospitalization rates and the risk of pancreatitis-related readmissions in Allegheny County, Pennsylvania, USA. Methods: We used Pennsylvania Health Care Cost Containment Council (PHC4) dataset to identify all unique White and Black Allegheny County residents with incident hospitalization for CP from years 1996–2005. We noted presence of alcoholism codes (from one year before index hospitalization until last contact) and pancreatitis-related readmissions until the third quarter of 2007. Age-, sex-, and race-adjusted (to US 2000 population) rates/100,000 were calculated. Results: 988 unique County residents with incident hospitalization for CP were identified. Of these, 37.6% also received alcoholism codes. Overall hospitalization rate was 7.75/100,000 (95% CI 7.26–8.24), which remained stable throughout the study period. Patients with alcoholism codes were significantly younger (47.2 vs. 58.0 years), more likely to be male (71.4 vs. 36.6%), and Black (38.5 vs. 17.7%). Hospitalization rates were significantly higher (2.4-fold) in Blacks (vs. Whites), particularly for those with alcoholism codes. During follow-up (median 45 months), pancreatitis-related readmissions were common, significantly more so for patients with alcoholism codes. Conclusions: CP hospitalization rates over a one-decade period were stable. Readmissions were highest among patients with a diagnosis of alcoholism.

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Danish Patients With Chronic Pancreatitis Have a Four-Fold Higher Mortality Rate Than the Danish Population

Cited by 58 publications

References 30 publications

Factors associated with long-term mortality in acute pancreatitis

Factors associated with long-term mortality in acute pancreatitis

Evidence-based clinical practice guidelines for chronic pancreatitis 2015

Hospitalizations for Chronic Pancreatitis in Allegheny County, Pennsylvania, USA

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