Danazol for uterine fibroids

Evaluation of the effects of cabergoline (Dostinex) on women with symptomatic myomatous uterus: a randomized trial

“…Prolactin can act as a growth hormone on myometrium and myoma tissue in the form of autocrine and paracrine; however, there is a difference between various myoma tissues with regards to sensitivity to this agent [28]. Therefore, prolactin lowering agents may be used to control the symptoms of myoma, as a medical treatment, similar to the other agents with competitive estrogen and progestin lowering potential which are used effectively for the treatment of the symptoms of myomatous uterus [6,25].…”

“…These medications cannot cure myoma, but may control the symptoms [6][7][8][9][10][11][12][13]. Also aromatase inhibitors [14][15][16][17][18][19][20][21][22][23][24] and danazol [25], have been used for the control of the symptoms based on the known estrogen effect on the growth of myoma.…”

Medical Management of Uterine Fibroids

“…Studies showed that danazol can reduce the size of fibroids by about 23.6% [1•].The side effects consist of acne, oily skin, voice changes, hirsutism, weight gain, and hepatocellular damage [50,68]. A recent review of the use of danazol for uterine fibroids concluded that the benefits of danazol do not outweigh its risks [69].…”

Medical Treatment of Fibroid to Decrease Rate of Hysterectomy

“…It reportedly induced a significant 24% volume reduction [79,80]. However, a recent Cochrane study failed to identify any randomized controlled trials that compared danazol to placebo or any other medical therapy in women with uterine fibroids [81].…”