Dammarane saponins of leaves of Panax pseudo-ginseng subsp. himalaicus

Tanaka, Osamu; Yahara, Shoji

doi:10.1016/s0031-9422(00)94588-6

Cited by 101 publications

(56 citation statements)

References 26 publications

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“…The carbon signals in the 13 C-NMR spectra of saponin 1 were found to be superimposable on those of an authentic sample of ginsenoside-Rd (0.87% from powdered roots), (Fig. 1) (Ma et al, 1999, Tanaka andYahara, 1978).…”

Section: Purification Of Active Compoundmentioning

confidence: 81%

Ginsenoside-Rd from Panax notoginseng enhances astrocyte differentiation from neural stem cells

Shi

Bouissac

et al. 2005

Life Sciences

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Section: Purification Of Active Compoundmentioning

confidence: 81%

Ginsenoside-Rd from Panax notoginseng enhances astrocyte differentiation from neural stem cells

Shi

Bouissac

et al. 2005

Life Sciences

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“…Based on chemical and spectral evidences including infrared spectroscopy, mass spectrometry, and nuclear magnetic resonance spectroscopy ( 1 H-NMR, 13 C-NMR, 1 H-1 H COSY, HMQC, HMBC spectra), these saponins were identified to be ginsenosides-Rh 1 (Rh 1 ),-Rh 4 (Rh 4 ),-Rg 1 (Rg 1 ),-Re (Re), notoginsenosides-R 1 (R 1 ),-R 2 (R 2 ),-U (U) (Fig. 2) [44][45][46][47][48][49]. Notoginsenoside U, a novel saponin, was characterized as 20(s)-protopanaxatriol 20-O-h-D-glucopyranosyl-(1Y6)-h-D-glucopyranoside [43].…”

Section: Extraction Isolation and Identification Of Saponinsmentioning

confidence: 99%

Structure and biological activity of protopanaxatriol-type saponins from the roots of Panax notoginseng

Sun

Yang

2006

International Immunopharmacology

105

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“…2) recently isolated from leaves of P. pseudoginseng subsp. himalaicus (Himalayan Panax)' (6). Ginsenoside Rgj was identified and isolated from American ginseng plants (4,7).…”

Section: Introductionmentioning

confidence: 99%

American ginseng. III. Pharmacokinetics of ginsenosides in the rabbit

Chen

Sawchuk

Staba

1980

European Journal of Drug Metabolism and Pharmacokinetics

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The pharmacokinetics of ginsenosides A1, A2, B2, and C were studied in rabbits and were best described with a one-component open model. Ginsenoside C (protopanaxadiol group ginseng saponin) showed a significantly longer half-life, higher plasma protein binding, and lower metabolic and renal clearance than ginsenosides A1, A2, and B2 (protopanaxatriol group ginseng saponins). All ginsenosides except ginsenoside A1 were slowly absorbed after intraperitoneal administration. Ginsenosides were not found in rabbit plasma or urine samples after oral administration. The observed differences in the pharmacokinetics of the ginsenosides may be ascribed to differences in protein binding. Ginsenoside C was more toxic than ginsenoside A2 after intraperitoneal administration to mice. Toxicity was not observed after oral administration of any of the ginsenosides. The genins, panaxadiol and panaxatriol, were more toxic and had larger volumes of distribution than the ginsenosides.

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Dammarane saponins of leaves of Panax pseudo-ginseng subsp. himalaicus

Cited by 101 publications

References 26 publications

Ginsenoside-Rd from Panax notoginseng enhances astrocyte differentiation from neural stem cells

Ginsenoside-Rd from Panax notoginseng enhances astrocyte differentiation from neural stem cells

Structure and biological activity of protopanaxatriol-type saponins from the roots of Panax notoginseng

American ginseng. III. Pharmacokinetics of ginsenosides in the rabbit

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