Damage of the Bronchopulmonary System in Patients With Chronic Hemoblastosis

Abstract

In 185 patients with chronic hemoblastosis (chronic lymphocytic leukemia, chronic myeloid leukemia, idiopathic myelofibrosis, multiple myeloma) after autopsy, the pathology of the bronchopulmonary system was studied. It was found out that in addition to immunodeficiency, an important role in the occurrence of respiratory diseases in chronic lymphocytic leukemia, as well as in chronic myeloid leukemia and idiopathic myelofibrosis in the stage of blast crisis is played by specific leukemic infiltration of the lungs, bronchi, pleura and diaphragm; the presence of leukostasis in the vessels of medium and small caliber with violation of microcirculation; compression of the diaphragm by significantly increased spleen and liver; in some cases (especially in chronic lymphocytic leukemia) hyperplasia of the lymphoid follicles of the bronchial tree. In chronic myeloid leukemia and idiopathic myelofibrosis, hyperthrombocytosis with the development of the sludge syndrome in small vessels of the lungs is essential. Pulmonary localization of inflammatory processes in patients with multiple myeloma is facilitated by lymphoid and plasma cell infiltration of the lungs, paraproteinosis of the lungs, localization of myeloma nodes in the ribs, lung tissue and bronchi.

Plasma Cell Tumors in Hematological Classifications of 2022: WHO-HAEM5 (WHO, 5th edition) and ICC (International Consensus Classification). A Clinician’s View

“…Солитарная плазмоцитома (СП) -редкая локализованная плазмоклеточная опухоль, поражающая кости, мягкие ткани или отдельные органы в виде одиночного образования без проявлений системного неопластического процесса [54,55]. Это ранний этап опухолевой прогрессии, располагающийся между МГНЗ и ММ (рис.…”