Dairy Products Intake and Endometrial Cancer Risk: A Meta-Analysis of Observational Studies

Abstract

Observational studies have suggested inconsistent findings on the relationship between dairy products intake and endometrial cancer risk. This study aimed to conduct a meta-analysis to evaluate this correlation; moreover, databases including PubMed, ISI Web of Science, and Embase were screened for relevant studies up to 26 February 2017. The inverse variance weighting method and random effects models were used to calculate the overall OR (odds ratio) values and 95% confidence interval (CI). A total of 2 cohort study and 16 case-control studies were included in the current analysis. No significant association was observed between endometrial cancer risk and the intake of total dairy products, milk, or cheese for the highest versus the lowest exposure category (total dairy products (14 studies): OR 1.04, 95% CI: 0.97–1.11, I2 = 73%, p = 0.000; milk (6 studies): 0.99, 95% CI: 0.89–1.10, I2 = 0.0%, p = 0.43; cheese (5 studies): 0.89, 95% CI: 0.76–1.05, I2 = 39%, p = 0.16). The only cohort study with a total of 456,513 participants reported a positive association of butter intake with endometrial cancer risk (OR = 1.14; 95% CI = 1.03–1.26, I2 = 2.6%, p = 0.31). There was a significant negative association of dairy products intake and endometrial cancer risk among women with a higher body mass index (BMI) (5 studies, OR 0.66, 95% CI = 0.46–0.96, I2 = 75.8%, p = 0.002). Stratifying the analyses by risk factors including BMI should be taken into account when exploring the association of dairy products intake with endometrial cancer risk. Further well-designed studies are needed.

Dairy Products and Cancer Risk in a Northern Sweden Population

“…In women, a high cheese consumption was associated with a modest decreased risk of all cancer, smoking-related and colorectal cancers, and hazards rations for fermented milk were generally below one though not statistically significant. These findings are consistent with other cohort studies around the world (9)(10)(11)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)45,46), with the WCRF's continuous update project (4), and to some extent also with another study performed in the same study population, where high intakes of fermented milk and cheese were associated with a lower mortality (47).…”

“…Consumption of dairy products has been evaluated in relation to cancer risk in cohort studies (16)(17)(18)(19)(20)(21) and cohort meta-analyses (10,(22)(23)(24)(25)(26)(27)(28)(29)(30). Comprehensive summaries of the evidence to date are regularly published by the World Cancer Research Fund (WCRF), as part of the Continuous Update Project.…”

“…In addition, adverse health effects of dairy consumption in gastric, (22), hepatocellular (21), renal (26), and ovarian cancer (30) have been suggested, as well as potential beneficial effects of fermented dairy products in bladder and esophageal cancer (26). Cancer sites with inconclusive results include endometrial (23), lung (10), pancreatic (25), breast, laryngeal, lymphoma, oral, and pharyngeal cancers (4,26). Interpretation of the epidemiological studies to date is hindered by different methods of categorizing dairy products, with some studies merging some or all dairy products (17,18), and others categorizing dairy products into common staple groups, such as non-fermented milk, fermented milk, and cheese (16,(19)(20)(21).…”

Cheese consumption and multiple health outcomes: an umbrella review and updated meta-analysis of prospective studies

“…Figure 1 shows the flowchart of the study search and selection process. We identified 54 eligible articles of meta-analyses/pooled analyses on 34 health outcomes, including 11 mortality outcomes [ 12 , [28] , [29] , [30] , [31] , [32] , [33] , [34] ] ( Supplemental Table 3 ), 4 CVD outcomes [ 13 , 28 , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] ] ( Supplemental Table 4 ), 13 cancer outcomes [ 14 , 32 , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , [66] ] ( Supplemental Table 5 ), 3 metabolic disease outcomes [ 15 , [67] , [68] , [69] , [70] , [71] , [72] ] ( Supplemental Table 6 ), and 3 aging-related outcomes [ 16 , 17 , [73] , [74] , [75] ] ( Supplemental Table 7 ). A total of 124 articles of original studies were extracted from previous meta-analyses, which combined with 63 newly added primary articles, resulting in 187 original articles.…”

Percepción de lo “saludable” y su relación con las marcas de alimentos en un grupo de adolescentes de la ciudad de Medellín, Colombia

“…En meta-análisis reciente se encontró que, de un total de 18 estudios, 14 estudios concluyeron que existe una relación entre la ingesta de alimentos procesados y/o ultra procesados con algunos tipos de cáncer. Por ejemplo, de siete estudios que evaluaron riesgo de cáncer de mama, cuatro encontraron una asociación positiva (Link et al, 2013;Harris, Willett, Vaidya y Michels, 2016;Krusinska et al, 2018;Krusińska et al, 2017). Así también, dos de tres estudios que evaluaron cáncer colorrectal encontraron mayor riesgo de cáncer (Fiolet et al, 2018).…”