Dairy Products, Dietary Calcium, and Risk of Inflammatory Bowel Disease

Opstelten, Jorrit L.; Leenders, Max; Dik, Vincent K.; Chan, Simon; Schaik, Fiona D.M. van; Khaw, Kay Tee; Luben, Robert; Hallmans, Göran; Karling, Pontus; Lindgren, Stefan; Grip, Olof; Key, Timothy J.; Crowe, Francesca L.; Boeing, Heiner; Bergmann, Manuela M.; Overvad, Kim; Palli, Domenico; Masala, Giovanna; Racine, Antoine; Carbonnel, Franck; Boutron-Ruault, Marie Christine; Tjønneland, Anne; Olsen, Anja; Andersen, Vibeke; Kaaks, Rudolf; Katzke, Verena; Tumino, Rosario; Trichopoulou, Antonia; Siersema, Peter D.; Bueno-De-Mesquita, H. Bas; Hart, Andrew; Oldenburg, Bas

doi:10.1097/mib.0000000000000798

Cited by 77 publications

(48 citation statements)

References 46 publications

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“…Some investigations report that a higher intake of milk is associated with a moderately increased risk of inflammatory bowel disease [44,45], whereas others find an inverse association or none [46][47][48][49][50]. In comparison to individuals that do not consume milk, the European Prospective Investigation into Cancer and Nutrition cohort including 401,326 participants reported that individuals consuming milk had significantly reduced odds of Crohn's disease (OR 0.30, 95% CI: 0.13-0.65) and nonsignificantly reduced odds of UC (OR 0.85, 95% CI: 0.49-1.47) [51]. Notably, pasteurized fresh milk in contrast to fermented milk products such as yoghurt contains bioactive milk exosomes [52].…”

Section: Discussionmentioning

confidence: 99%

Milk Exosomes Prevent Intestinal Inflammation in a Genetic Mouse Model of Ulcerative Colitis: A Pilot Experiment

Stremmel¹,

Weiskirchen

Melnik

2020

Inflamm Intest Dis

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Background: Milk is rich in nutrients and anabolic mediators rendering it essential for postnatal growth and metabolic programming. However, in adults, excessive consumption of milk is controversial as civilization disorders such as diabetes or prostate cancer may be promoted. A cytoprotective effect of milk could be utilized in inflammatory conditions, that is, chronic colitis. Objective: To evaluate the effect of bovine milk exosomes on intestinal inflammation in a genetic mouse model of ulcerative colitis. Methods: Intestinal-specific kindlin 2 knockout (KO) mice were exposed for 4 days to tamoxifen for induction of an ulcerative colitis phenotype. At the same time 4 other kindlin 2 KO mice were exposed to 33 μg/g cow milk derived exosomes in PBS by oral gavage. Both groups were compared to untreated wild-type controls. Results: Milk exosomes prevented the appearance of a severe ulcerative phenotype. The macroscopic colitis score dropped from a mean of 3.33 in untreated mice to 0.75 index points (p < 0.01) in exosome-treated mice, which included significant improvement of the subscores of stool improvement and colon weight and length. Treated mice featured a noninflamed appearance of the intestinal mucosa. Key Message: Milk exosomes have cytoprotective/anti-inflammatory activity in a genetic mouse model of ulcerative colitis. The mechanisms behind this need to be elucidated. This pilot study needs verification before a therapeutic strategy is developed.

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Section: Discussionmentioning

confidence: 99%

Milk Exosomes Prevent Intestinal Inflammation in a Genetic Mouse Model of Ulcerative Colitis: A Pilot Experiment

Stremmel¹,

Weiskirchen

Melnik

2020

Inflamm Intest Dis

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“…The European Investigation into Cancer and Nutrition study found that individuals that consumed milk had significantly reduced odds of developing CD (OR: 0.30, 95% CI: 0.13–0.65), suggesting a protective effect with dairy product consumption [28]. Individual dairy products consisted of milk, yogurt, and cheese with varying fat content (e.g., full fat, skimmed, semi-skimmed, and unspecified).…”

Section: Diet In the Etiology Of Ibdmentioning

confidence: 99%

An Examination of Diet for the Maintenance of Remission in Inflammatory Bowel Disease

Haskey

Gibson

2017

Nutrients

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Diet has been speculated to be a factor in the pathogenesis of inflammatory bowel disease and may be an important factor in managing disease symptoms. Patients manipulate their diet in attempt to control symptoms, often leading to the adoption of inappropriately restrictive diets, which places them at risk for nutritional complications. Health professionals struggle to provide evidence-based nutrition guidance to patients due to an overall lack of uniformity or clarity amongst research studies. Well-designed diet studies are urgently needed to create an enhanced understanding of the role diet plays in the management of inflammatory bowel disease. The aim of this review is to summarize the current data available on dietary management of inflammatory bowel disease and to demonstrate that dietary modulation may be an important consideration in managing disease. By addressing the relevance of diet in inflammatory bowel disease, health professionals are able to better support patients and collaborate with dietitians to improve nutrition therapy.

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“…CIDs are complex diseases with both genetic and environmental factors involved in the disease development. Some genetic and environmental susceptibility factors are shared between the CIDs whereas other factors might differ [4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25]. CIDs are frequent; IBD affects up to 0.5% of the population in the Western world [26] and RA and PsO have global prevalences of 0.3–1.0% and 1.5%, respectively [27,28].…”

Section: Introductionmentioning

confidence: 99%

A Proposal for a Study on Treatment Selection and Lifestyle Recommendations in Chronic Inflammatory Diseases: A Danish Multidisciplinary Collaboration on Prognostic Factors and Personalised Medicine

et al. 2017

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Chronic inflammatory diseases (CIDs), including Crohn’s disease and ulcerative colitis (inflammatory bowel diseases, IBD), rheumatoid arthritis, psoriasis, psoriatic arthritis, spondyloarthritides, hidradenitis suppurativa, and immune-mediated uveitis, are treated with biologics targeting the pro-inflammatory molecule tumour necrosis factor-α (TNF) (i.e., TNF inhibitors). Approximately one-third of the patients do not respond to the treatment. Genetics and lifestyle may affect the treatment results. The aims of this multidisciplinary collaboration are to identify (1) molecular signatures of prognostic value to help tailor treatment decisions to an individual likely to initiate TNF inhibitor therapy, followed by (2) lifestyle factors that support achievement of optimised treatment outcome. This report describes the establishment of a cohort that aims to obtain this information. Clinical data including lifestyle and treatment response and biological specimens (blood, faeces, urine, and, in IBD patients, intestinal biopsies) are sampled prior to and while on TNF inhibitor therapy. Both hypothesis-driven and data-driven analyses will be performed according to pre-specified protocols including pathway analyses resulting from candidate gene expression analyses and global approaches (e.g., metabolomics, metagenomics, proteomics). The final purpose is to improve the lives of patients suffering from CIDs, by providing tools facilitating treatment selection and dietary recommendations likely to improve the clinical outcome.

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Dairy Products, Dietary Calcium, and Risk of Inflammatory Bowel Disease

Abstract: Milk consumption may be associated with a decreased risk of developing CD, although a clear dose-response relationship was not established. Further studies are warranted to confirm this possible protective effect.

Cited by 77 publications

References 46 publications

Milk Exosomes Prevent Intestinal Inflammation in a Genetic Mouse Model of Ulcerative Colitis: A Pilot Experiment

Milk Exosomes Prevent Intestinal Inflammation in a Genetic Mouse Model of Ulcerative Colitis: A Pilot Experiment

An Examination of Diet for the Maintenance of Remission in Inflammatory Bowel Disease

A Proposal for a Study on Treatment Selection and Lifestyle Recommendations in Chronic Inflammatory Diseases: A Danish Multidisciplinary Collaboration on Prognostic Factors and Personalised Medicine

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