An Examination of Diet for the Maintenance of Remission in Inflammatory Bowel Disease

Abstract

Diet has been speculated to be a factor in the pathogenesis of inflammatory bowel disease and may be an important factor in managing disease symptoms. Patients manipulate their diet in attempt to control symptoms, often leading to the adoption of inappropriately restrictive diets, which places them at risk for nutritional complications. Health professionals struggle to provide evidence-based nutrition guidance to patients due to an overall lack of uniformity or clarity amongst research studies. Well-designed diet studies are urgently needed to create an enhanced understanding of the role diet plays in the management of inflammatory bowel disease. The aim of this review is to summarize the current data available on dietary management of inflammatory bowel disease and to demonstrate that dietary modulation may be an important consideration in managing disease. By addressing the relevance of diet in inflammatory bowel disease, health professionals are able to better support patients and collaborate with dietitians to improve nutrition therapy.

Patient, parent and professional perception of the use of maintenance enteral nutrition in Paediatric Crohn's Disease

“…Families stated a preference for nutritional support as dietary advice instead of MEN. Young people and parents reported an increased interest in their diet after diagnosis, similar to previous findings . Engaging young people with CD in the co‐design of studies on healthy diet and lifestyle choices may positively impact clinical and nutritional outcomes in adulthood and as a patient‐led practice may improve quality of life .…”

Diet Modifies Colonic Microbiota and CD4+ T Cell Repertoire to Trigger Flares in a Novel Model of Colitis Induced by IL-23

“…Our results indicate that diet is a critical factor affecting development of IL-23-driven experimental IBD, and suggest that it does so by modifying the microbiota. Dietary constituents have been shown to affect the immune response and the inflammatory status, in part by modulating the microbiota 22,50 Our studies showed a marked reduction in alpha diversity as function of the diet change.…”

“…Mice bearing specific gene alterations develop colitis, but a significant number of them do not develop colitis when raised in germ-free conditions, suggesting a critical role for genes and the microbiota in promoting disease 4,20 . Other animal studies suggest a critical role of dietary components in the onset and severity of colitis [21][22][23] . Yet, the development of relapsingremitting disease models has not been reported.…”

Increasing incidence of inflammatory bowel disease in children and adolescents: significance of environmental factors

“…23) Haskey et al showed that a high protein intake, especially from animal protein, resulted in a 3.3 time increased risk of IBD, suggesting that a diet high in animal protein was a major risk factor. 23) With respect to the intake of dietary fats, a high n3 polyunsaturated fatty acid (PUFA) to n6 PUFA ratio is reportedly inversely associated with the risk of IBD. 2325) Several studies have shown the influence of certain components contained in food on epithelial cell permeability.…”