Dairy product consumption is associated with pre-diabetes and newly diagnosed type 2 diabetes in the Lifelines Cohort Study

Brouwer‐Brolsma, Elske M.; Sluik, Diewertje; Singh-Povel, Cécile M; Feskens, Edith J. M.

doi:10.1017/s0007114517003762

Cited by 42 publications

(53 citation statements)

References 47 publications

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“…This study demonstrated an increased risk for T2DM by milk consumption in five of eight countries . The Dutch Lifeline Cohort Study with 112 086 participants investigated the association of nonfermented milk products, milk, and fermented milk products on participants with prediabetes (defined as fasting plasma glucose between 5.6 and 6.9 mmol/L or HbA1c of 5.7%‐6.4%) and newly diagnosed T2DM (defined as fasting plasma glucose ≥7.0 mmol/l or HbA1c ≥ 6.5%) . A positive association between full‐fat milk consumption (150 g/day) as well as nonfermented dairy products with prediabetes has been shown.…”

Section: Introductionmentioning

confidence: 74%

“…A positive association between full‐fat milk consumption (150 g/day) as well as nonfermented dairy products with prediabetes has been shown. Notably, a significant positive association between milk (serving 150 g/day) and predominantly skimmed milk consumption (150 g/day) with T2DM has been detected …”

Section: Introductionmentioning

confidence: 87%

“…Taken together, high milk intake was not associated with a lower risk of T2DM or overweight‐obesity in Danish individuals . A positive association between milk intake and T2DM has been confirmed in the EPIC and Dutch Lifeline Cohort Study . Furthermore, the supplementation of whey concentrates in children increased insulin resistance …”

Section: Introductionmentioning

confidence: 99%

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Milk consumption does not prevent but induces type 2 diabetes

Melnik

Schmitz

2019

Diabetes Metabolism Res

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1 | INTRODUCTION Hidayat et al 1 recently proposed in this journal that milk consumption may prevent type 2 diabetes mellitus (T2DM) especially by enhancement of incretin and insulin responses, consequently leading to lower postprandial glucose levels. Milk's insulinotropic index is three times higher compared with milk's glycemic index. The insulinotropic protein fraction of milk are the whey proteins (20% of cow milk protein), whereas caseins (80%) enhance serum levels of insulin-like growth factor-1 (IGF-1). In fact, whey ingestion increases the secretion of glucose-dependent insulinotropic polypeptide (GIP) and enhances insulin responses lowering postprandial glucose levels in healthy individuals and patients with T2DM. 1 The branched-chain amino acids (BCAAs) leucine, isoleucine, and valine are the major insulinotropic amino acid constituents of whey proteins. BCAAs activate mTORC1 of β-cells and promote β-cell proliferation, insulin synthesis, and insulin secretion. 2 Physiologically, the BCAA-mTORC1 signalling of milk is restricted to the postnatal breastfeeding period. 3 Adult mammals are naturally protected from milk intake after the weaning period by physiological lactose intolerance except humans who acquired LCT mutation-induced lactase persistence allowing persistent milk consumption. A Mendelian randomization study in 97 811 Danish individuals demonstrated that milk intake is not associated with a lower risk of T2DM or overweight-obesity, but in contrast identified an increased risk of T2DM. 4 Of all animal-derived proteins, milk proteins contain the highest amount of BCAAs with leucine levels in the range of 10% to 11%. Enhanced serum levels of BCAAs are metabolomic hallmarks of obesity, insulin resistance, and T2DM. 5 Decreasing dietary BCAA levels improved obesity, insulin sensitivity, appetite control, and lifespan in mice. 6,7 High concentrations of leucine repressed β-cell differentiation in pancreatic bud cultures through the activation of the mTORC1 signalling pathway. 8 Hyperstimulation of mTORC1 by high concentrations of leucine inhibits β-cell proliferation by alterations of hypoxia-inducible factor 1α and via S6 kinase 1 (S6K1)-mediated inhibitory phosphorylation of insulin receptor substrate-1 (IRS1) inducing insulin resistance (Figure 1). 9 The combination of persistent glucose-mediated and leucine-mediated overstimulation of mTORC1driven insulin synthesis enhances endoplasmic reticulum (ER) stress of β-cells resulting in early β-cell apoptosis, the key pathogenic mechanism of T2DM. 5,10 Furthermore, it is noteworthy to mention that pasteurized milk provides bioavailable exosomal microRNAs including the diabetogenic microRNA-29b. 11 MicroRNA-29b serum levels significantly increase after consumption of commercial pasteurized milk. 11 MicroRNA-29b targets and suppresses the expression of dihydrolipoamide branchedchain transacylase (DBT), the functionally important core protein of branched-chain α-ketoacid dehydrogenase (BCKD), and the key enzyme of BCAA catabolism. Thus, consumption of p...

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Section: Introductionmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 87%

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Milk consumption does not prevent but induces type 2 diabetes

Melnik

Schmitz

2019

Diabetes Metabolism Res

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“…Terdapat hubungan yang signifikan antara konsumsi total dairy dengan diabetes melitus tipe 2 di Belanda Bagian Utara dan Belanda Bagian Selatan (p<0,05). 18,19 Di Malaysia, diabetes melitus tipe 2 berhubungan dengan skor HbA1c (p<0,05). 20 Di Spanyol, konsumsi susu ≤14 kali dalam seminggu berhubungan dengan diabetes melitus (p<0,05).…”

Section: Hubungan Konsumsi Susu Dan Produk Olahannya Dengan Kejadian unclassified

“…Berdasarkan hasil penelitian di Belanda, konsumsi produk skim tidak berhubungan dengan kejadian diabetes melitus tipe 2, baik di Belanda Bagian Utara maupun Bagian Selatan (p>0,05). 18,19 Hasil ini berbanding terbalik dengan produk yogurt dimana konsumsi yogurt berhubungan secara signifikan dengan kejadian DMT2 di kedua bagian Negara Belanda tersebut (p<0,05; OR<1). 18,19 Kemudian pada penelitian di Belanda Bagian Utara, produk buttermilk (OR > 1) dan minuman yogurt (OR<1) berhubungan secara signifikan dengan DMT2 di Belanda Bagian Utara (p<0,05).…”

Section: Hubungan Konsumsi Susu Dan Produk Olahannya Dengan Kejadian unclassified

Hubungan antara Konsumsi Susu dan Produk Olahannya dengan Diabetes Melitus Tipe 2 : Review Literatur

Badzlina

Triyanti

2019

mpk

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Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by chronic hyperglycemia due to impaired insulin secretion, insulin action, or both. T2DM can cause complications in various organs of the body and can increase the risk of death. Complications that may be experienced by people with T2DM are heart attack, stroke, kidney failure, leg amputation, blindness, and nerve damage. Good lifestyle management is very important in handling T2DM, including education and medical nutrition therapy. The dietary guidelines for people with T2DM are the amount of intake, type of food and schedule of meals. The purpose of this literature review is to analyze the association between consumption of dairy products with the risk of T2DM. The design of this study was Literature review. The type of articles used were research articles published from 2013 to 2018. Articles collected from the database were then selected using inclusion criteria: 1) the purpose of the article was to analyze the association between the intake of milk or its processed products to the incidence of diabetes; 2) was a cross-sectional study; 3) respondents aged ≥18 years, and obtained 4 articles as the final results. The results showed that consumption of dairy product, including the type of products, were protective against T2DM. People who consume dairy products have lower HbA1c levels 0,6 times than those who didn’t consume. However, milk consumption ≤14 times a week can increase the risk of T2DM. The conclusion of this study is that consumption of dairy products are protective against T2DM. Abstrak Diabetes melitus tipe 2 (DMT2) merupakan penyakit metabolik yang ditandai dengan terjadinya hiperglikemia kronis akibat gangguan sekresi insulin, kerja insulin, atau keduanya. DMT2 dapat menyebabkan komplikasi di berbagai organ tubuh dan dapat meningkatkan risiko kematian. Komplikasi yang mungkin dialami oleh penderita DMT2 ialah serangan jantung, stroke, gagal ginjal, amputasi kaki, kebutaan, dan kerusakan saraf. Manajemen gaya hidup yang baik sangat penting dalam penanganan DMT2, termasuk edukasi serta terapi gizi medis. Panduan pola makan untuk penderita DMT2 bersifat individual berdasarkan prinsip 3J, yaitu jumlah asupan, jenis makanan serta jadwal makan. Tujuan dari kajian literatur ini adalah untuk menganalisa hubungan konsumsi susu dan produk olahannya dengan risiko DMT2. Desain penelitian ini adalah literatur review. Jenis artikel yang digunakan ialah artikel penelitian yang dipublikasikan dari tahun 2013 sampai 2018. Artikel yang terkumpul dari database kemudian diseleksi dengan menggunakan kriteria inklusi: 1) tujuan artikel menganalisis hubungan asupan susu atau produk olahannya terhadap kejadian DMT2; 2) merupakan penelitian cross-sectional; 3) responden berusia ≥18 tahun, dan diperoleh empat artikel sebagai hasil akhir. Hasil penelitian menunjukkan bahwa konsumsi susu dan beberapa produk olahannya, termasuk jenis produk– produknya, bersifat protektif terhadap DMT2. Orang yang mengonsumsi susu dan produk olahannya memiliki kadar HbA1c lebih rendah 0,6 kali dibandingkan dengan yang tidak. Namun, konsumsi susu ≤14 kali dalam seminggu dapat meningkatkan risiko DMT2. Kesimpulan penelitian ini adalah susu dan beberapa produk olahannya bersifat protektif terhadap DMT2.

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The Role of Milk and Dairy Products in the Development of Obesity and Cardiometabolic Disease

Dougkas

Hobbs

2020

Handbook of Eating and Drinking

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Dairy product consumption is associated with pre-diabetes and newly diagnosed type 2 diabetes in the Lifelines Cohort Study

Cited by 42 publications

References 47 publications

Milk consumption does not prevent but induces type 2 diabetes

Milk consumption does not prevent but induces type 2 diabetes

Hubungan antara Konsumsi Susu dan Produk Olahannya dengan Diabetes Melitus Tipe 2 : Review Literatur

The Role of Milk and Dairy Products in the Development of Obesity and Cardiometabolic Disease

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