Daily versus stat vitamin D supplementation during pregnancy; A prospective cohort study

Abstract

Background Despite favorable climatic conditions, vitamin D deficiency (VDD) is widespread in Pakistan. Current study was aimed to evaluate the prevalence of VDD in Pakistani pregnant women and effectiveness of various regimen of Vitamin D supplementation. Methodology This hospital-based prospective cohort study included pregnant women at 12 th to 24 th weeks of gestation attending Gynae clinic from October 2018 to April 2019. Patients were classified into control and treatment groups (Groups: G 1 , G 2 and G 3) according to the dose of vitamin D supplementation. Patients received various regimens of vitamin D including 2000 IU/day (G 1), 5000 IU/day (G 2) and stat 200000 IU (G 3). The levels of vitamin D were measured before and after supplementation. The effectiveness of dosages were compared between and within the groups. Moreover, factors associated with vitamin D sufficiency and insufficiency were ascertained using appropriate statistical methods. Results Among 281 pregnant women (mean age: 28.22 ± 4.61 years), VDD was prevalent in 47.3% cases. Vitamin D supplementation caused significant rise in the levels 25(OH)D in treatment groups, while there was no significant difference in control group. The highest mean increment in vitamin D (23.14 ± 11.18 ng/ml) was observed with dose 5000 IU/day followed by doses 200000 IU stat (21.06 ± 13.73 ng/ml) and 2000 IU/day (10.24 ± 5.65 ng/ml). Vitamin D toxicity was observed in one patient who received 200000 IU stat of vitamin D. The frequency of VDD following the supplementation was 5.7%. Education status, duration of sun exposure and use of sunblock was substantially associated with vitamin D sufficiency in the current study.

Impact of vitamin D on the course of COVID-19 during pregnancy: A case control study

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A Basic Review of the Preliminary Evidence That COVID-19 Risk and Severity Is Increased in Vitamin D Deficiency

“…Effective study doses of vitamin D were most often in the range of 400-2,000 IU (10-50 mcg), with the higher doses being given to adults (104). A 2020 study of pregnant women also found that daily supplementation is superior to boluses, that 2,000 IU/day was sufficient to resolve deficiency over time, and that up to 5,000 IU/day is safe (111).…”

Gestational Diabetes Mellitus—Innovative Approach to Prediction, Diagnosis, Management, and Prevention of Future NCD—Mother and Offspring

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