Daily supplementation with fresh pomegranate juice increases paraoxonase 1 expression and activity in mice fed a high-fat diet

Estrada-Luna, Diego; Martínez-Hinojosa, E.; Cancino-Diaz, Mario E.; Belefant-Miller, Helen; López-Rodríguez, Guadalupe; Betanzos‐Cabrera, Gabriel

doi:10.1007/s00394-017-1394-2

Cited by 43 publications

(47 citation statements)

References 34 publications

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“…According to previous research, changes exerted by MP on APOA1 may occur for a number of reasons. For example, polyphenols from pomegranate juice increase the serum activity and hepatic mRNA expression of paraoxonase 1 (PON1), an enzyme that closely associates with HDL particles, which results in decreased serum lipids in mice that are fed diets rich in fat, cholesterol and sodium cholate . Cyanidin has been shown to promote RCT by increasing mRNA expression of ABCA1 and ABCG1 transporters in human aortic endothelial cells, and both transporters play important roles in preventing cholesterol overload by exporting it to HDL .…”

Section: Resultsmentioning

confidence: 99%

“…For example, polyphenols from pomegranate juice increase the serum activity and hepatic mRNA expression of paraoxonase 1 (PON1), an enzyme that closely associates with HDL particles, which results in decreased serum lipids in mice that are fed diets rich in fat, cholesterol and sodium cholate. 55 Cyanidin has been shown to promote RCT by increasing mRNA expression of ABCA1 and ABCG1 transporters in human aortic endothelial cells, and both transporters play important roles in preventing cholesterol overload by exporting it to HDL. 56 An anthocyanin-rich black elderberry extract has been shown to improve HDL function and decrease aortic cholesterol in hyperlipidemic mice by modulating the hepatic mRNA expression of various HDL-related genes, without significant changes to the serum HDL or APOA1 concentration.…”

Section: Gene Expressionmentioning

confidence: 99%

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Mango phenolics increase the serum apolipoprotein A1/B ratio in rats fed high cholesterol and sodium cholate diets

et al. 2018

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Section: Resultsmentioning

confidence: 99%

Section: Gene Expressionmentioning

confidence: 99%

Mango phenolics increase the serum apolipoprotein A1/B ratio in rats fed high cholesterol and sodium cholate diets

et al. 2018

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“…36,37 Similarly, the lack of PJ effect on the total and LDL cholesterol in our study may be partly due to relatively normal levels of these lipids in the participants as other studies on diabetes patients with elevated blood lipids showed promising results. 38,39 The lipid-lowering and anti-atherogenic properties of pomegranate may be attributed to a number of mechanisms such as regulating the expression of the genes involved in lipogenesis and fatty acid oxidation in the liver 40 ; increasing the expression and activity of paraoxonase-1; the antioxidant enzyme in HDL particles which prevents LDL oxidation 41 ; and suppression of oxidized LDL degradation and of cholesterol synthesis in macrophages. 42 Along the same lines as our results, investigations have reported pomegranate antioxidant potential as evidenced by decreased MDA 38,39,43,44 and increased serum total TAC.…”

Section: Discussionmentioning

confidence: 99%

Pomegranate juice improves cardiometabolic risk factors, biomarkers of oxidative stress and inflammation in hemodialysis patients: a randomized crossover trial

et al. 2019

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BACKGROUND Pomegranate has antioxidant, cardioprotective and anti‐inflammatory properties. We designed a crossover study aimed at determining if consumption of pomegranate juice (PJ) improves lipid profile and oxidative and inflammatory biomarkers of hemodialysis patients. Forty‐one hemodialysis patients were randomly assigned to one of two groups: PJ‐treated group receiving 100 mL of natural PJ immediately after their dialysis session three times a week and the control group receiving the usual care. After 8 weeks, a 4‐week washout period was established and then the role of the groups was exchanged. Lipid profile, blood pressure and oxidative and inflammatory biomarkers were measured before and after each sequence. RESULTS Based on the results of intention‐to‐treat analysis, triglycerides were decreased in PJ condition and increased in the controls. Conversely, high‐density lipoprotein cholesterol was increased in PJ and decreased in the control group. Total and low‐density lipoprotein cholesterol did not significantly change in either condition. Systolic and diastolic blood pressure significantly decreased in PJ condition. Total antioxidant capacity increased in PJ condition (P < 0.001) and decreased in the controls (P < 0.001). Conversely, malondialdehyde and interleukin‐6 decreased in PJ (P < 0.001) and increased in the control group (P ≤ 0.001). The changes of these biomarkers were significantly different between the two conditions. CONCLUSIONS Eight‐week PJ consumption showed beneficial effects on blood pressure, serum triglycerides, high‐density lipoprotein cholesterol, oxidative stress and inflammation in hemodialysis patients. © 2019 Society of Chemical Industry

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“…PON1 is synthesized in the liver and transported in plasma in association with HDL. The decrease in the PON1 activity may lead to higher levels of cholesterol (Estrada-Luna et al, 2018). Other associated paraoxonase are PON2 and PON3.…”

Section: Introductionmentioning

confidence: 99%

Effect of Saudi and Egyptian pomegranate polyphenols in regulating the activity of PON1, PON2 and lipid profile for preventing coronary heart disease

BinMowyna

Binobead

Badr

et al. 2019

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Saudi and Egyptian pomegranate juice (APJ and EPJ) contains potent polyphenols antioxidants which were found to reduce serum and macrophage oxidative stress. The protective effects of APJ and EPJ against atherogenicity were evaluated by feeding mice with hypercholesterolemic diet supplemented with PJ. PJ consumption reduced mice serum Triglycerides (TG), Total cholesterol (TC) and (low density lipoprotein (LDL-c) and increase in the High-density lipoprotein (HDL-c) compared with mouse with control diet or atherogenic diet. The risk ratio and atherogenic index were significantly lower in either APJ or EPJ supplemented group. Paraoxonase 1 (PON1) which remains associated with HDL showed significant increase in the activity in mice supplemented with PJ compared to mice with atherogenic diet (AD). PJ consumption significantly reduced lipid peroxidation and increased glutathione levels. The reduction in lipid peroxidation varied from 57 to 76%. PJ supplementation reduced peritoneal macrophages (MPM) mediated oxidation of LDL by 68 to 82% and decreased mouse peritoneal macrophages (MPM) Ox-LDL uptake by 31 to 48%. A significant up regulation of macrophage PON2 activity was induced by PJ reducing the macrophage oxidative stress. In conclusion, PJ consumption resulted in anti-oxidative and antiatherogenic effects on serum and macrophages which could prevent atherosclerosis and coronary heart diseases.

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Daily supplementation with fresh pomegranate juice increases paraoxonase 1 expression and activity in mice fed a high-fat diet

Abstract: These results suggest that PJ protects against the effects of a high-fat diet in body weight, and cholesterol levels.

Cited by 43 publications

References 34 publications

Mango phenolics increase the serum apolipoprotein A1/B ratio in rats fed high cholesterol and sodium cholate diets

Mango phenolics increase the serum apolipoprotein A1/B ratio in rats fed high cholesterol and sodium cholate diets

Pomegranate juice improves cardiometabolic risk factors, biomarkers of oxidative stress and inflammation in hemodialysis patients: a randomized crossover trial

Effect of Saudi and Egyptian pomegranate polyphenols in regulating the activity of PON1, PON2 and lipid profile for preventing coronary heart disease

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