Daily rhythm of salivary and serum urea concentration in sheep

Piccione, Giuseppe; Foà, Augusto; Bertolucci, Cristiano; Caola, G.

doi:10.1186/1740-3391-4-16

Cited by 22 publications

(15 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the same animals the acrophases of serum urea were recorded at 11:40 hours and 12:24 hours, on days 1 and 2 respectively, and it is important to emphasise that animals were fed once daily at 07:00 hours. These acrophases are similar to those found in sheep under the same natural photoperiod and feeding regimen 11 . The highest concentration of urea reached in the saliva follows that reached in the blood.…”

Section: Discussionsupporting

confidence: 83%

“…Therefore, saliva is an appropriate specimen in fields such as physiology, psychology, sports medicine, pharmacology, immunology, paediatrics and geriatric medicine 5–7 . In veterinary medicine, only a few studies of saliva have been carried out, mostly in sheep, 8–10 whereas chronophysiological studies of human saliva are widely documented 11–13 . Therefore, the aim of the present study was to define non‐invasive experimental protocols for animals and to underline the importance of saliva samples as the main or complementary diagnostic means in veterinary chronophysiology.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Daily rhythms of serum and salivary parameters in goats

et al. 2009

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 83%

mentioning

confidence: 99%

Daily rhythms of serum and salivary parameters in goats

et al. 2009

View full text Add to dashboard Cite

show abstract

“…In pigs, a decrease of free fatty acids in serum was seen within 1 h after feeding (Houpt et al, 1986), and insulin in plasma was found to increase postprandial (Koopmans et al, 2005). Moreover, plasma urea varies throughout the day in relation to the time of feeding (Gustafsson and Palmquist, 1993;Rodriguez et al, 1997;Piccione et al, 2006). In sheep, Caldeira et al (1999) published variation of most routine analytes depending on feeding time and level of feed intake; however, in this study, ewes had access to food just once a day, which may not be comparable with ordinary conditions, for example, at pasture.…”

Section: Animal-related Changesmentioning

confidence: 92%

Pre-analytical factors affecting the results of laboratory blood analyses in farm animal veterinary diagnostics

Humann-Ziehank

Ganter

2012

Animal

View full text Add to dashboard Cite

The quality of the laboratory diagnostic approach in farm animals can be severely affected by pre-analytical factors of variation. They induce increase/decrease of biochemical and hematological analyte concentrations and, as a consequence, they may cause unsuitable conclusions and decisions for animal health management and research projects. The pre-analytical period covers the preparation of sampling, the sampling procedure itself, as well as all specimen handling until the beginning of the specific laboratory analysis. Pre-analytical factors may have either an animal-related or a technique-related background. Animal-related factors cover daytime/season, meals/fasting, age, gender, altitude, drugs/anesthesia, physical exercise/stress or coinfection. Technique-related factors are the choice of the tube including serum v. plasma, effects of anticoagulants/gel separators, the anticoagulant/blood ratio, the blood collection procedure itself, specimen handling, contamination, labeling, storage and serum/plasma separation, transportation of the specimen, as well as sample preparation before analysis in the laboratory. It is essential to have proper knowledge about the importance and source of pre-analytical factors to alter the entire diagnostic process. Utmost efforts should be made to minimize controllable factors. Analytical results have to be evaluated with care considering that pre-analytical factors of variation are possible causes of misinterpretation.

show abstract

“…Because the deamination of amino acids produces levels of ammonia that could be life threatening, its elimination via conversion to urea is essential for survival. Proteomic analysis reveals that members of the urea cycle oscillate in the liver (14,28), and urea has been reported to oscillate in the blood of several species (28,(61)(62)(63)(64)(65). As blood flow into the liver is a circadian event, it is possible that some metabolites represent physiological oscillations that are independent of hepatocyte production; however, these still reflect the changing diurnal landscape of hepatic metabolism.…”

Section: Discussionmentioning

confidence: 99%

Coordination of the transcriptome and metabolome by the circadian clock

Eckel‐Mahan

Patel

Mohney

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

355

297

View full text Add to dashboard Cite

The circadian clock governs a large array of physiological functions through the transcriptional control of a significant fraction of the genome. Disruption of the clock leads to metabolic disorders, including obesity and diabetes. As food is a potent zeitgeber (ZT) for peripheral clocks, metabolites are implicated as cellular transducers of circadian time for tissues such as the liver. From a comprehensive dataset of over 500 metabolites identified by mass spectrometry, we reveal the coordinate clock-controlled oscillation of many metabolites, including those within the amino acid and carbohydrate metabolic pathways as well as the lipid, nucleotide, and xenobiotic metabolic pathways. Using computational modeling, we present evidence of synergistic nodes between the circadian transcriptome and specific metabolic pathways. Validation of these nodes reveals that diverse metabolic pathways, including the uracil salvage pathway, oscillate in a circadian fashion and in a CLOCK-dependent manner. This integrated map illustrates the coherence within the circadian metabolome, transcriptome, and proteome and how these are connected through specific nodes that operate in concert to achieve metabolic homeostasis.C ircadian rhythms exist within a wide range of biological processes and control numerous aspects of physiology, including the sleep/wake cycle, eating, hormone and neurotransmitter secretion, and even cognitive function (1-4). Integral to the modern lifestyle is the ability to eat, sleep, work, exercise, and socialize around the clock and yet these allowances may serve as a preamble to obesity and other metabolic disorders. Recent studies reveal that a distorted circadian cycle can lead to aberrations in metabolism, producing symptoms such as obesity, insulin resistance, and others consistent with the metabolic syndrome (5-9). Whereas studies focused on night-shift and rotating shift workers emphasize the link between circadian rhythmicity and metabolism, rodent models of circadian arrhythmia also support this link (10-13). As an essential modulator of metabolism in vivo, the liver provides a cardinal domain in which to study interactions between the clock and metabolism as much of the liver transcriptome and proteome oscillates in expression or activity. These circadian characteristics of the liver are dependent largely on the zeitgeber (ZT), food (14-21).Precision within the circadian clock depends on nuclear transcriptional and translational feedback loops, but recent evidence that circadian, nontranscriptional, and nontranslational cytosolic rhythms crosstalk with nuclear rhythms to maintain circadian timing provides support for the idea that metabolites may affect the transcriptional-translational canonical clock system and vice versa (22,23). Some biochemical oscillations have been shown to cycle in a circadian fashion, such as calcium, 3′-5′-cyclic adenosine monophosphate (cAMP) and nicotinamide (NAD + ) (24-27). These oscillations feed into the clock system and can modulate circadian dynamics in vivo. Sever...

show abstract

Daily rhythm of salivary and serum urea concentration in sheep

Cited by 22 publications

References 13 publications

Daily rhythms of serum and salivary parameters in goats

Daily rhythms of serum and salivary parameters in goats

Pre-analytical factors affecting the results of laboratory blood analyses in farm animal veterinary diagnostics

Coordination of the transcriptome and metabolome by the circadian clock

Contact Info

Product

Resources

About