Daily Physical Activity and Symptom Reporting in Breast Cancer Patients Undergoing Chemotherapy: An Intensive Longitudinal Examination

Abstract

Background: Increased activity is beneficial during chemotherapy, but treatment-related symptoms may be a barrier. This study examines the relationship between daily fluctuations in symptoms and activity during chemotherapy. Methods: Women undergoing chemotherapy for breast cancer [n = 67; Mage = 48.6 (SD = 10.3)] wore an accelerometer 24 hours/day and received four text prompts/day to rate symptoms for 10 consecutive days at the beginning, middle, and end of chemotherapy. Mixed-effects models were used to examine the between and within-person relationships between symptom ratings on a given day and moderate to vigorous physical activity (MVPA) and light physical activity (LPA) on that day and the following day controlling for relevant covariates and using the Bonferroni correction for multiple comparisons. Results: For MVPA and LPA, within-person associations were statistically significant for same day affect, fatigue, pain, walking, activities of daily living (ADL) physical function, and cognitive function. Previous day anxiety was associated with next day LPA. Every one point worse symptom rating than an individual's overall average was associated with: (i) between 1.49 (pain) and 4.94 (fatigue) minutes less MVPA and between 4.48 (pain) and 24.72 (ADL physical function) minutes less LPA that day, and (ii) 11.28 minutes less LPA the next day. No between-person effects were significant for MVPA or LPA. Conclusions: Daily within-person variations in symptoms were associated with MVPA and LPA during chemotherapy for breast cancer. Impact: Future work should explore relationships between symptoms and activity further and identify whether tailoring to symptoms enhances efficacy of physical activity promotion interventions during chemotherapy.

Social cognitive variables and physical activity during chemotherapy for breast cancer: An intensive longitudinal examination

“…Finally, each construct was measured with only a single‐item one time per day because of concerns about overburdening participants and we did not include a measure specific to barriers/facilitators (i.e., enjoyment, social support), an important SCT construct, within these analyses. However, in a prior analysis in this sample we did find common chemotherapy symptoms were related to MVPA and LPA participation 33 . Future work could examine SCT constructs at an even more microtemporal level as self‐efficacy, for example, may change even within a single day or a few hours 37 .…”

“…As reported in full elsewhere, 33 participants engaged in an average of 22.74 (SD = 27.57) minutes of MVPA and 228.44 (SD = 92.64) minutes of LPA per day, both of which were relatively consistent across time point (T1: MVPA M = 22.22 [SD = 21.87], LPA M = 226.66 [SD = 81.15]; T2: MVPA M = 22.39 [SD = 26.85], LPA M = 230.41 [SD = 99.45]; T3: MVPA M = 23.78 [SD = 33.85]; LPA M = 228.36 [SD = 97.62]). Mixed models regressing treatment time point (T1, T2, and T3) and treatment status (pre‐chemotherapy dose vs.. day of/post‐chemotherapy dose) separately on MVPA and LPA revealed some differences by time point, by treatment status, and the time point by treatment–status interaction.…”

“…However, in a prior analysis in this sample we did find common chemotherapy symptoms were related to MVPA and LPA participation. 33 Future work could examine SCT constructs at an even more microtemporal level as self-efficacy, for example, may change even within a single day or a few hours. 37 Future studies could also examine these relationships using similar study methods over longer periods of time and across the survivorship continuum (i.e., pre-/postsurgery, immediately following treatment, several months or years post-treatment) using more frequent and/or robust measures of these constructs.…”

Image Effect Observation of Acanthopanax senticosus on Antifatigue Activity after Exercise

“…They carried out ¥ maze learning training on people and found that the amplitude of group spike evoked by perforin fibers 4 hours and 24 hours after training was significantly higher than that before training. Among them, the LTP effect of people with good memory increased significantly, while the LTP effect of people with poor memory did not increase significantly [ 11 ]. Conversely, studies have shown that factors or drugs that affect LTP can also affect learning and memory processes.…”

The effect of peer support psychoeducation based on experiential learning on self-care demands among breast cancer patients with post-chemotherapy

“…Breast cancer patients undergoing chemotherapy had problems especially related to self-care. 3 , 4 The patient is unable to perform activity daily living which can decrease the quality of life and lead to anxiety and depression. 5 A previous study mentioned that in breast cancer patients, almost 50% of respondents need assistance from other people to fulfill their nutritional and fluid needs mobilization, toileting, bathing, and personal hygiene supervision.…”