Image Effect Observation of Acanthopanax senticosus on Antifatigue Activity after Exercise

Zhang, Xiangdong; Zhu, Wanning

doi:10.1155/2022/7588680

Cited by 7 publications

(8 citation statements)

References 24 publications

(24 reference statements)

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“…The studies have shown that sleep deprivation causes excessive oxidation of free radicals in brain tissue, leading to degenerative changes in tissues and cells, making excessive lipofuscin and malondialdehyde (MDA), thus damaging brain function and reducing learning and memory capacity. In this study, ESF has been proved to significantly improve the above symptoms and counter the effects of chronic sleep deprivation on the central nervous system (Zhang & Zhu, 2022 ). The main components of ESF volatile oil and fatty oil were terpene and fatty acid compounds by GC–MS analysis.…”

Section: Resultsmentioning

confidence: 97%

Comprehensive analysis of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. fruits based on UPLC–MS/MS and GC–MS: A rapid qualitative analysis

Chang,

Jiang,

Chen

et al. 2023

Food Science & Nutrition

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Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. fruits (ESF), as a natural edible fruit, has long been popularized. However, few studies have conducted comprehensive chemical analyses of it. This study aimed to assess nonvolatile, volatile, and fatty oil components of ESF and to preliminarily explore the antioxidant activities. The qualitative and quantitative analyses of volatile and fatty oil components of ESF from 15 different regions were performed by the gas chromatography–mass spectrometry (GC–MS). Totally, 37 and 28 compounds were identified from volatile oil and fatty oil, respectively. The ultra‐high‐performance liquid chromatography–quadrupole time‐of‐flight mass spectrometry (UPLC–QTOF–MS/MS) was used to accurately detect 43 compounds of nonvolatile components. The volatile and fatty oil components and nonvolatile components of ESF were used as samples to determine the antioxidant activity of 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) in vitro. The components of ESF had antioxidant activity, and the nonvolatile components had stronger antioxidant activity. The results revealed that the proposed method, which is of great significance for the screening of new active ingredients, is valuable for the identification of pharmaceutical component and further development of food industry.

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Section: Resultsmentioning

confidence: 97%

Comprehensive analysis of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. fruits based on UPLC–MS/MS and GC–MS: A rapid qualitative analysis

Chang,

Jiang,

Chen

et al. 2023

Food Science & Nutrition

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“…E. sessiliflorus is a traditional tonic Chinese herbal medicine from the Changbai Mountain region of China, with mild medicinal properties, low toxicity, and antioxidant, anti-aging, and anti-fatigue properties ( Li et al, 2016 ; Jia et al, 2021 ; Li et al, 2022 ; Zhang and Zhu, 2022 ). E. sessiliflorus is rich in a variety of active ingredients, such as plant proteins, peptides, and polysaccharides, all of which have potent and strong antioxidant activity and hold promise for antioxidant drug development.…”

Section: Discussionmentioning

confidence: 99%

Isolation and purification of Eleutherococcus sessiliflorus (Rupr. & Maxim.) S. Y. Hu peptides and study of their antioxidant effects and mechanisms

Liu,

Ding,

Xie

et al. 2024

Front. Pharmacol.

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Oxidative stress is a state of imbalance between oxidant and antioxidant effects in the body, which is closely associated with aging and many diseases. Therefore, the development of antioxidants has become urgent. In this study, we isolated three polypeptides, G-6-Y, P-8-R, and F-10-W, from Eleutherococcus sessiliflorus (Rupr. & Maxim.) S. Y. Hu (E. sessiliflorus), based on the antioxidant and anti-aging properties of Eleutherococcus, and screened the most powerful free radical scavenging peptide P-8-R. Ultraviolet B (UVB)-induced oxidative stress damage in the skin was established to test the efficacy of P-8-R. In cellular experiments, P-8-R not only prevented oxidative stress damage in HaCaT cells, reduced intracellular reactive oxygen species levels, and inhibited the overexpression of matrix metalloproteinases but also inhibited apoptosis via the mitochondria-dependent apoptotic pathway; in animal experiments, P-8-R was able to prevent oxidative stress damage in the skin and reduce skin collagen loss by inhibiting the overexpression of MMPs to prevent mouse skin aging. In conclusion, the present study contributes to an in-depth understanding of the active compounds of Eleutherococcus, which is of great significance for the pharmacodynamic mechanism and industrial development of Eleutherococcus, and P-8-R is likely to become a potential antioxidant and anti-aging drug or skin care cosmetic in the future.

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“…AS is a medicinal plant in the family of Araliaceae. Previous studies have shown that the active ingredients of AS can significantly improve blood lipid levels and endothelial cell function in patients with acute cerebral infarction, promote the proliferation of neural stem cells in ischemic brain tissue and have therapeutic effects on cerebrovascular diseases such as hypertension and cerebral infarction [18][19][20]. In addition, AS has a sedative effect on the central nervous system, which can improve anxiety, irritability, insomnia, and other symptoms, and is commonly used clinically for the treatment of abnormal affective disorders and neurological disorders [21][22].…”

Section: Discussionmentioning

confidence: 99%

Efficient Extraction and Purification of Isofraxidin from Acanthopanax Senticosus by DES

Sun¹,

Hou²,

Sun³

et al. 2023

Preprint

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Acanthopanax senticosus(rupr. rt. Maxim.; AS) is a medicinal plant used in the clinical treatment of cerebrovascular diseases and central nervous system disorders, significantly improving blood lipid levels and endothelial cell function in patients with acute cerebral infarction. Isofraxidin, one of the active ingredients of AS, is the core of the medical effects, and its extraction and purification depend on organic solvents. Deep eutectic solvents (DESs) is a new green solvent, synthesized by intermolecular hydrogen bonding between hydrogen bond donors (HBD) and hydrogen bond acceptors (HBA), which has non-toxic, high separation and purification efficiency, and environmentally friendly compared with traditional organic solvents. In this paper, DES was used for the extraction of isofraxidin from AS. The primary findings demonstrate that the DESs had a viscosity higher than that of ethanol, and even adding a tiny amount of water (about 10%) would trigger solvent redistribution, leading to a considerable reduction in solvent viscosity. In comparison to ethanol, the extraction rate of isofraxidin by DESs was 2-3 times higher. Thus, this work developed a new technique for using green extraction of isofraxidin that has some practical implications.

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Image Effect Observation of Acanthopanax senticosus on Antifatigue Activity after Exercise

Cited by 7 publications

References 24 publications

Comprehensive analysis of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. fruits based on UPLC–MS/MS and GC–MS: A rapid qualitative analysis

Comprehensive analysis of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. fruits based on UPLC–MS/MS and GC–MS: A rapid qualitative analysis

Isolation and purification of Eleutherococcus sessiliflorus (Rupr. & Maxim.) S. Y. Hu peptides and study of their antioxidant effects and mechanisms

Efficient Extraction and Purification of Isofraxidin from Acanthopanax Senticosus by DES

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