Daily Oral Administration of Protease-Treated Royal Jelly Protects Against Denervation-Induced Skeletal Muscle Atrophy

Shirakawa, Tomohiko; Miyawaki, Aki; Matsubara, Takuma; Okumura, Nobuaki; Okamoto, Hideto; Nakai, Norihiro; Rojasawasthien, Thira; Morikawa, Kazumasa; Inoue, Asako; Goto, Akino; Washio, Ayako; Tsujisawa, Toshiyuki; Kawamoto, T.; Kokabu, Shoichiro

doi:10.3390/nu12103089

Cited by 22 publications

(21 citation statements)

References 51 publications

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“…Among the enzymes and factors involved in apoptosis, caspase-3 degrades a variety of cytoplasmic and nuclear proteins and activates nucleases, which promote DNA degradation [ 53 ]. Thus, the detection of caspase-3 by immunocytochemistry assays has been used to identify and confirm cell death via apoptosis [ 54 ]. Since NSY-224(60) and WMTA did not change the number of Ki-67- and caspase-3-positive cells, both materials are considered to have no apoptotic effect and induce cell proliferation.…”

Section: Discussionmentioning

confidence: 99%

Physicochemical Properties, Cytocompatibility, and Biocompatibility of a Bioactive Glass Based Retrograde Filling Material

et al. 2021

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The ideal retrograde filling material that is easy to handle, has good physicochemical properties, and is biocompatible has not yet been developed. The current study reports the development of a novel bioactive glass based powder for use as a retrograde filling material that is capable of altering the consistency and hardening rate of mixtures when mixed with existing bioactive glass based cement. Furthermore, its physicochemical properties, in vitro effects on human cementoblast-like cells, and in vivo effects on inflammatory responses were evaluated. The surface of the hardened cement showed the formation of hydroxyapatite-like precipitates and calcium and silicate ions were eluted from the cement when the pH level was stabilized at 10.5. Additionally, the cement was found to be insoluble and exhibited favorable handling properties. No adverse effects on viability, proliferation, and expression of differentiated markers were observed in the in vitro experiment, and the cement was capable of inducing calcium deposition in the cells. Moreover, the cement demonstrated a lower number of infiltrated inflammatory cells compared to the other materials used in the in vivo mouse subcutaneous implantation experiment. These findings suggest that the retrograde filling material composed of bioactive glass and the novel bioactive glass based powder exhibits favorable physicochemical properties, cytocompatibility, and biocompatibility.

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Section: Discussionmentioning

confidence: 99%

Physicochemical Properties, Cytocompatibility, and Biocompatibility of a Bioactive Glass Based Retrograde Filling Material

et al. 2021

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“…Royal jelly is rich in multiple fatty acids, such as trans-10-hydroxy-2-decenoic acid and 10-hydroxydecanoic acid. It attenuates denervation-induced skeletal muscle atrophy in C57BL/6J mice and stimulates myoblast proliferation and differentiation of C2C12 cells [81].…”

Section: Fatty Acidsmentioning

confidence: 96%

Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy

Wang

Liu²,

Quan

et al. 2021

Nutrients

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Imbalance of protein homeostasis, with excessive protein degradation compared with protein synthesis, leads to the development of muscle atrophy resulting in a decrease in muscle mass and consequent muscle weakness and disability. Potential triggers of muscle atrophy include inflammation, malnutrition, aging, cancer, and an unhealthy lifestyle such as sedentariness and high fat diet. Nutraceuticals with preventive and therapeutic effects against muscle atrophy have recently received increasing attention since they are potentially more suitable for long-term use. The implementation of nutraceutical intervention might aid in the development and design of precision medicine strategies to reduce the burden of muscle atrophy. In this review, we will summarize the current knowledge on the importance of nutraceuticals in the prevention of skeletal muscle mass loss and recovery of muscle function. We also highlight the cellular and molecular mechanisms of these nutraceuticals and their possible pharmacological use, which is of great importance for the prevention and treatment of muscle atrophy.

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“…RJ removed protein (protease-treated RJ [pRJ]) also had a positive effect on skeletal muscle. Daily oral administration of pRJ prevents denervation-induced skeletal muscle atrophy [ 99 ], and it has been reported that pRJ affects muscle fiber thickness, expression of satellite cell catabolic gene, and proliferation and differentiation in C2C12 myoblasts [ 99 , 100 ].…”

Section: Natural Compounds (Effective Foods Against Denervation-induced Skeletal Muscle Atrophy)mentioning

confidence: 99%

Natural Compounds Attenuate Denervation-Induced Skeletal Muscle Atrophy

Shirakawa

Miyawaki

Kawamoto

et al. 2021

IJMS

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The weight of skeletal muscle accounts for approximately 40% of the whole weight in a healthy individual, and the normal metabolism and motor function of the muscle are indispensable for healthy life. In addition, the skeletal muscle of the maxillofacial region plays an important role not only in eating and swallowing, but also in communication, such as facial expressions and conversations. In recent years, skeletal muscle atrophy has received worldwide attention as a serious health problem. However, the mechanism of skeletal muscle atrophy that has been clarified at present is insufficient, and a therapeutic method against skeletal muscle atrophy has not been established. This review provides views on the importance of skeletal muscle in the maxillofacial region and explains the differences between skeletal muscles in the maxillofacial region and other regions. We summarize the findings to change in gene expression in muscle remodeling and emphasize the advantages and disadvantages of denervation-induced skeletal muscle atrophy model. Finally, we discuss the newly discovered beneficial effects of natural compounds on skeletal muscle atrophy.

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Daily Oral Administration of Protease-Treated Royal Jelly Protects Against Denervation-Induced Skeletal Muscle Atrophy

Cited by 22 publications

References 51 publications

Physicochemical Properties, Cytocompatibility, and Biocompatibility of a Bioactive Glass Based Retrograde Filling Material

Physicochemical Properties, Cytocompatibility, and Biocompatibility of a Bioactive Glass Based Retrograde Filling Material

Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy

Natural Compounds Attenuate Denervation-Induced Skeletal Muscle Atrophy

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