Natural Compounds Attenuate Denervation-Induced Skeletal Muscle Atrophy

Shirakawa, Tomohiko; Miyawaki, Aki; Kawamoto, T.; Kokabu, Shoichiro

doi:10.3390/ijms22158310

Cited by 6 publications

(4 citation statements)

References 169 publications

(183 reference statements)

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“…This statin-damage work has also been substantiated in animal studies (Goodman et al, 2015;Irwin et al, 2018). Oral administration of GG rescues muscle atrophy through atrogin-1 suppression (Miyawaki et al, 2020) and reverses skeletal muscle atrophy that includes oral frailty such as oral conversation and food mastication (Shirakawa et al, 2021). In muscles, statin increased atrogin-1 by about 100%-150%, followed by a consequent reduction of 30%-35% muscle force production for which GG completely abrogated.…”

Section: Role Of Gg In Managing Samsmentioning

confidence: 87%

Potential role of geranylgeraniol in managing statin-associated muscle symptoms: a COVID-19 related perspective

Tan,

Chin

2023

Front. Physiol.

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Myopathy is the most common side effect of statins, but it has not been addressed effectively. In anticipation of its wider use as a small molecule to complement the current COVID-19 management, a pharmacological solution to statin-associated muscle symptoms (SAMS) is warranted. Statins act by suppressing the mevalonate pathway, which in turn affects the downstream synthesis of isoprenoids required for normal physiological functions. CoQ10 and geranylgeraniol (GG) syntheses are reduced by statin use. However, CoQ10 supplementation has not been shown to reverse SAMS. GG is an obligatory substrate for CoQ10 synthesis, an endogenous nutrient critical for skeletal muscle protein synthesis. Multiple studies showed GG supplementation is effective in reversing SAMS. This opinion paper proposes employing GG to prevent SAMS in pleiotropic statin use, including usage in the post-COVID-19 pandemic era.

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Section: Role Of Gg In Managing Samsmentioning

confidence: 87%

Potential role of geranylgeraniol in managing statin-associated muscle symptoms: a COVID-19 related perspective

Tan,

Chin

2023

Front. Physiol.

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“…In the category of skeletal muscle adaptation and sarcoplasmic reticulum, alternations of subcategories such as the response to denervation involved in regulation of muscle adaptation and the regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum were recognized. The altered profile of genes belongs to the term protein catabolism, which we have already pointed out, might be attributed to an accompanying phenomenon of atrophy induced by a denervation-like behavior generated by protein restriction [ 26 ]. Meanwhile, the abnormal calcium ion release may bring functional dissonance during muscle contraction and relaxation [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Transcriptome and Methylome Profiling in Rat Skeletal Muscle: Impact of Post-Weaning Protein Restriction

Hasegawa

Nakai

et al. 2022

IJMS

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Skeletal muscle is programmable, and early-life nutritional stimuli may form epigenetic memory in the skeletal muscle, thus impacting adult muscle function, aging, and longevity. In the present study, we designed a one-month protein restriction model using post-weaning rats, followed by a two-month rebound feeding, to investigate how early-life protein restriction affects overall body growth and muscle development and whether these influences could be corrected by rebound feeding. We observed comprehensive alterations immediately after protein restriction, including retarded growth, altered biochemical indices, and disturbed hormone secretion. Transcriptome profiling of the gastrocnemius muscle followed by gene ontology analyses revealed that “myogenic differentiation functions” were upregulated, while “protein catabolism” was downregulated as a compensatory mechanism, with enhanced endoplasmic reticulum stress and undesired apoptosis. Furthermore, methylome profiling of the gastrocnemius muscle showed that protein restriction altered the methylation of apoptotic and hormone secretion-related genes. Although most of the alterations were reversed after rebound feeding, 17 genes, most of which play roles during muscle development, remained altered at the transcriptional level. In summary, early-life protein restriction may undermine muscle function in the long term and affect skeletal muscle development at the both transcriptional and methylation levels, which may hazard future muscle health.

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“…Results are presented in rainforest plots [ 50 ] where uncertainty is visualized by the height of the raindrops for each individual estimate while the width of the raindrop corresponds to the estimated CI. All analyses were conducted in R version 4.1 [ 51 ] using the following packages: tidyverse [ 52 ], meta [ 53 ], dmetar [ 54 ] metafor [ 55 ] and metaviz [ 56 ].…”

Section: Methodsmentioning

confidence: 99%

Efficacy of Topical Essential Oils in Musculoskeletal Disorders: Systematic Review and Meta-Analysis of Randomized Controlled Trials

et al. 2023

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Essential oils (EOs) are widely used topically in musculoskeletal disorders (MSDs); however, their clinical efficacy is controversial. Our aim was to find evidence that topical EOs are beneficial as an add-on treatment in MSDs. We performed a systematic review and meta-analysis to summarize the evidence on the available data of randomized controlled trials (RCTs). The protocol of this work was registered on PROSPERO. We used Web of Science, EMBASE, PubMed, Central Cochrane Library and Scopus electronic databases for systematic search. Eight RCTs were included in the quantitative analysis. In conclusion, EO therapy had a favorable effect on pain intensity (primary outcome) compared to placebo. The greatest pain-relieving effect of EO therapy was calculated immediately after the intervention (MD of pain intensity = −0.87; p = 0.014). EO therapy had a slightly better analgesic effect than placebo one week after the intervention (MD of pain intensity = −0.58; p = 0.077) and at the four-week follow-up as well (MD of pain intensity = −0.52; p = 0.049). EO therapy had a beneficial effect on stiffness (a secondary outcome) compared to the no intervention group (MD = −0.77; p = 0.061). This systematic review and meta-analysis showed that topical EOs are beneficial as an add-on treatment in reducing pain and stiffness in the investigated MSDs.

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Natural Compounds Attenuate Denervation-Induced Skeletal Muscle Atrophy

Cited by 6 publications

References 169 publications

Potential role of geranylgeraniol in managing statin-associated muscle symptoms: a COVID-19 related perspective

Potential role of geranylgeraniol in managing statin-associated muscle symptoms: a COVID-19 related perspective

Transcriptome and Methylome Profiling in Rat Skeletal Muscle: Impact of Post-Weaning Protein Restriction

Efficacy of Topical Essential Oils in Musculoskeletal Disorders: Systematic Review and Meta-Analysis of Randomized Controlled Trials

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