Daily Opioid Use Fluctuates as a Function of Pain, Catastrophizing, and Affect in Patients With Sickle Cell Disease: An Electronic Daily Diary Analysis

Abstract

The present study shows that pain and pain-related cognitive and affective variables are associated with daily variation in prescription opioid use in SCD. The findings may have broad implications for tracking and defining risk for prescription opioid misuse in patients with daily pain.

Predictors of Gabapentin Overuse With or Without Concomitant Opioids in a Commercially Insured U.S. Population

“…Exclusion criteria for the previous studies included cancer, use of narcotic patches or fentanyl, or chronic kidney disease. For the present study, an additional exclusion criterion was sickle cell disease, as this population often has fluctuating, distorted opioid (and potentially gabapentin) dose requirements …”

Red blood cell transfusion therapy for sickle cell patients with frequent painful events

“…These data suggest that even during a well‐designed clinical trial, patients with recurrent episodes of acute vaso‐occlusive pain administered hydroxyurea therapy may continue to have frequent need for healthcare utilization. Additional important nonpharmacological treatments for pain are increasingly recognized and include an intensive multidisciplinary approach that incorporates self‐efficacy, cognitive behavioral therapy, guided imagery, and catastrophizing management . However, the availability of resources to support these multidisciplinary approaches likely limits their widespread adoption.…”

“…guided imagery, and catastrophizing management. [7][8][9] However, the availability of resources to support these multidisciplinary approaches likely limits their widespread adoption. Chronic transfusion therapy offers another possible treatment for patients with frequent pain events.…”

Targeting pain at its source in sickle cell disease

“…In patients with SCD, this part of the brain is hyperactive and may contribute to exaggerated pain perception by the patient. Sociopsychological factors leading to cognitive impairment have been described to influence pain and opioid requirement in patients with SCD (31). In addition, cerebral infarction in SCD subjects also results in a significant decline of neuropsychological functions, IQ, and cognitive score (5, 10, 13, 22, 26, 71, 87).…”