Daily ingestion of catechin-rich beverage increases brown adipose tissue density and decreases extramyocellular lipids in healthy young women

Nirengi, Shinsuke; Amagasa, Shiho; Homma, Toshiyuki; Yoneshiro, Takeshi; Matsumiya, S; Kurosawa, Yuko; Ebi, Kumiko; Saito, Masayuki; Hamaoka, Toshiyuki

doi:10.1186/s40064-016-3029-0

Cited by 48 publications

(62 citation statements)

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“…Longitudinal studies revealed that an increase in BAT activity induced by repeated ingestion of thermogenic food ingredients can be detected by an increase in [Total-Hb] [40]. Collectively, [Total-Hb] in the supraclavicular region evaluated by NIR TRS is expected to be suitable for evaluating BAT density (BAT-d) and equivalent to the determination of BAT activity or BAT volume by 18 FDG-PET/CT using cold exposure [39][40][41][42].…”

Section: Introductionmentioning

confidence: 99%

Vigorous-Intensity Physical Activities Are Associated with High Brown Adipose Tissue Density in Humans

Tanaka

Fuse

Kuroiwa

et al. 2020

IJERPH

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Brown adipose tissue (BAT) plays a role in adaptive thermogenesis in response to cold environments and dietary intake via sympathetic nervous system (SNS) activation. It is unclear whether physical activity increases BAT density (BAT-d). Two-hundred ninety-eight participants (age: 41.2 ± 12.1 (mean ± standard deviation), height: 163.6 ± 8.3 cm, weight: 60.2 ± 11.0 kg, body mass index (BMI): 22.4 ± 3.0 kg/m2, body fat percentage: 25.4 ± 7.5%) without smoking habits were categorized based on their physical activity levels (a group performing physical activities including walking and moderate physical activity (WM) and a group performing WM + vigorous-intensity physical activities (VWM)). We measured the total hemoglobin concentration ([Total-Hb]) in the supraclavicular region, an index of BAT-d, and anthropometric parameters. [Total-Hb] was significantly higher in VWM than WM for all participant groups presumably owing to SNS activation during vigorous-intensity physical activities, and unrelated to the amount of total physical activity levels. Furthermore, multiple regression analysis revealed that BAT-d was related to visceral fat area and VWM in men and related to body fat percentage in women. We conclude that vigorous-intensity physical activities are associated with high BAT-d in humans, especially in men.

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Section: Introductionmentioning

confidence: 99%

Vigorous-Intensity Physical Activities Are Associated with High Brown Adipose Tissue Density in Humans

Tanaka

Fuse

Kuroiwa

et al. 2020

IJERPH

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“…The probes were placed on the skin of the supraclavicular region that potentially contained BAT, and participants were required to remain in a sitting position during the measurements, as previously described. [23][24][25][26] Compared with visible light wavelengths, NIR wavelengths (700 to 3000 nm) show lesser scattering and, consequently, better penetration into biological tissue. However, light absorption by water limits tissue penetration above the 900-nm wavelength; thus, the 650-to 900-nm range is suitable for measurements.…”

Section: Brown Adipose Tissue Density Measurementsmentioning

confidence: 99%

“…Collectively, the NIR TRS method is expected to be suitable for evaluating BAT density (BAT-d) in men and women, which is equivalent to the active BAT intensity or the amount of BAT, as determined by 18 FDG-PET∕CT with cold exposure. [23][24][25][26] As the NIR TRS method was introduced only in 2015, there are no data on the relationship of BAT with age, sex, anthropometrical parameters, and environmental factors. To verify the usefulness of NIR TRS , there is a need to accumulate evidence on analogous data with regards to 18 FDG-PET∕CT with cold exposure.…”

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Brown adipose tissue density measured by near-infrared time-resolved spectroscopy in Japanese, across a wide age range

et al. 2018

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"Brown adipose tissue density measured by near-infrared time-resolved spectroscopy in Japanese, across a wide age range," J. Biomed. Opt. 23(6), 065002 (2018), doi: 10.1117/1.JBO.23.6.065002. Abstract. 18 F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) along with computed tomography (CT) is a standard method for assessing brown adipose tissue (BAT) activity. We tested the usefulness of near-infrared time-resolved spectroscopy (NIR TRS ) as a simple and noninvasive method for evaluating BAT density (BAT-d) by examining the effects of some factors known to influence BAT activity. The total hemoglobin concentration as a parameter of BAT-d was evaluated using NIR TRS in the supraclavicular region in 413 Japanese individuals. The associations were analyzed between BAT-d and sex, age, the percentages of body fat (%BF), visceral fat (VF), and the seasonal ambient temperature (AmT) fluctuations. Age was associated with decreased BAT-d (P < 0.05). There was no sex difference in the BAT-d, except for those in their twenties. Multivariate analyses revealed that %BF and VF were correlated with BAT-d, and the lower AmT (around 4°C or 5°C) for 4 and 6 weeks prior to the measurement day was associated with an increase in the BAT-d. Our NIR TRS results were analogous to those reported with 18 FDG-PET∕CT, indicating the usefulness of NIR TRS . BAT-d might increase during the 4 and 6 weeks after the AmT decreases to lower than 4°C or 5°C. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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“…In the present study, participants were in the fasting state for over 12 h at the time of test beverage intake, and because they were not given a meal or supplied with lipids and carbohydrates along with the test beverage, a decrease in the RQ might not have occurred. Moreover, tea catechins with caffeine reportedly activate brown adipose tissue in young people [9,31]. Although it is possible that the tea catechin with caffeine-induced EE increase involves the activation of brown adipose tissue, further studies are needed to evaluate the effects of tea catechins with caffeine on brown adipose tissue in middle-aged individuals.…”

Section: Discussionmentioning

confidence: 99%

Effect of tea catechins with caffeine on energy expenditure in middle-aged men and women: a randomized, double-blind, placebo-controlled, crossover trial

et al. 2019

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Purpose It has been reported that tea catechins increase energy metabolism, but their effect on resting metabolic rate (RMR) remains under debate. This study aimed to examine the effect of repeated intake of tea catechins on energy metabolism in the resting state in middle-aged men and women. Methods A total of 30 middle-aged men and women [13 women; age (mean ± SD) 52 ± 4 years; BMI 21.9 ± 2.2 kg/m 2 ] were recruited. A randomized, double-blind, crossover study was conducted using a tea catechin-enriched beverage (611 mg catechins, 88 mg caffeine) and a placebo beverage (0 mg catechins, 81 mg caffeine) as test beverages. After 2 weeks of continuous test beverage intake, fasting RMR and energy expenditure (EE) after the ingestion of test beverage were measured. Measurements of forehead temperature (proxy for core temperature) and skin temperature were also obtained simultaneously. Results Among participants who underwent measurements, 26 (10 women; mean age 52 ± 4 years; mean BMI 22.1 ± 2.1 kg/ m 2 ) were analyzed. The EE increased significantly after ingestion of the tea catechin beverage compared with the placebo beverage (placebo treatment: 5502 ± 757 kJ/day; catechin treatment: 5598 ± 800 kJ/day; P = 0.041). No between-treatment differences in fasting RMR or the respiratory quotient were detected. In addition, the forehead and skin temperature did not differ significantly between the placebo and catechin treatments. Conclusion This study revealed that continuous intake of tea catechins with caffeine for 2 weeks significantly increased EE after ingestion of the tea catechin but not fasting RMR in middle-aged men and women. Clinical Trial Registry number and website This trial was registered at www.umin.ac.jp/ctr/ as UMIN000025810 and UMIN000025811. KeywordsBody temperature · Energy expenditure · Middle-aged men and women · Resting metabolic rate · Tea catechins Abbreviations DBP Diastolic blood pressure DEXA Dual-energy X-ray absorptiometry EE Energy expenditure EGCg Epigallocatechin gallate FFM Fat-free mass FM Fat mass FSH Follicle-stimulating hormone HbA1c Glycated hemoglobin iAUC Incremental area under the curve LH Luteinizing hormone RMR Resting metabolic rate RQ Respiratory quotient SBP Systolic blood pressure T3 Triiodothyronine T4 Thyroxine Electronic supplementary material The online version of this article (https ://doi.org/10.

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Daily ingestion of catechin-rich beverage increases brown adipose tissue density and decreases extramyocellular lipids in healthy young women

Cited by 48 publications

References 52 publications

Vigorous-Intensity Physical Activities Are Associated with High Brown Adipose Tissue Density in Humans

Vigorous-Intensity Physical Activities Are Associated with High Brown Adipose Tissue Density in Humans

Brown adipose tissue density measured by near-infrared time-resolved spectroscopy in Japanese, across a wide age range

Effect of tea catechins with caffeine on energy expenditure in middle-aged men and women: a randomized, double-blind, placebo-controlled, crossover trial

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