Effect of tea catechins with caffeine on energy expenditure in middle-aged men and women: a randomized, double-blind, placebo-controlled, crossover trial

Abstract

Purpose It has been reported that tea catechins increase energy metabolism, but their effect on resting metabolic rate (RMR) remains under debate. This study aimed to examine the effect of repeated intake of tea catechins on energy metabolism in the resting state in middle-aged men and women. Methods A total of 30 middle-aged men and women [13 women; age (mean ± SD) 52 ± 4 years; BMI 21.9 ± 2.2 kg/m 2 ] were recruited. A randomized, double-blind, crossover study was conducted using a tea catechin-enriched beverage (611 mg catechins, 88 mg caffeine) and a placebo beverage (0 mg catechins, 81 mg caffeine) as test beverages. After 2 weeks of continuous test beverage intake, fasting RMR and energy expenditure (EE) after the ingestion of test beverage were measured. Measurements of forehead temperature (proxy for core temperature) and skin temperature were also obtained simultaneously. Results Among participants who underwent measurements, 26 (10 women; mean age 52 ± 4 years; mean BMI 22.1 ± 2.1 kg/ m 2 ) were analyzed. The EE increased significantly after ingestion of the tea catechin beverage compared with the placebo beverage (placebo treatment: 5502 ± 757 kJ/day; catechin treatment: 5598 ± 800 kJ/day; P = 0.041). No between-treatment differences in fasting RMR or the respiratory quotient were detected. In addition, the forehead and skin temperature did not differ significantly between the placebo and catechin treatments. Conclusion This study revealed that continuous intake of tea catechins with caffeine for 2 weeks significantly increased EE after ingestion of the tea catechin but not fasting RMR in middle-aged men and women. Clinical Trial Registry number and website This trial was registered at www.umin.ac.jp/ctr/ as UMIN000025810 and UMIN000025811. KeywordsBody temperature · Energy expenditure · Middle-aged men and women · Resting metabolic rate · Tea catechins Abbreviations DBP Diastolic blood pressure DEXA Dual-energy X-ray absorptiometry EE Energy expenditure EGCg Epigallocatechin gallate FFM Fat-free mass FM Fat mass FSH Follicle-stimulating hormone HbA1c Glycated hemoglobin iAUC Incremental area under the curve LH Luteinizing hormone RMR Resting metabolic rate RQ Respiratory quotient SBP Systolic blood pressure T3 Triiodothyronine T4 Thyroxine Electronic supplementary material The online version of this article (https ://doi.org/10.

Effect of Acute and Chronic Dietary Supplementation with Green Tea Catechins on Resting Metabolic Rate, Energy Expenditure and Respiratory Quotient: A Systematic Review

“…A strength of this systematic review is the fact that the included studies considered green tea extracts or, at least, very small amounts of caffeine (<50 mg of the total content of green tea extract). Recent interesting studies have investigated the effects of green tea extract supplementation on metabolic parameters and body composition, but these supplement had high caffeine contents [ 69 , 70 , 71 ]. The same observation was first carried out by Dullo et al, who revealed that the effects of the green tea extract in enhancing thermogenesis and fat oxidation could not solely be explained on the basis of its caffeine content, because treatment with an amount of caffeine equivalent to that in the extract failed to alter EE, RQ, or substrate oxidation [ 26 ].…”

Current Status of Obesity: Protective Role of Catechins

“…Scientists took baseline measurements, measured fasting, resting metabolic rate (RMR) and EE after the 2-week ingestion of test beverage, and simultaneously measured forehead temperature (a proxy for core temperature) and skin temperature. Results indicated that EE increased significantly after ingestion of the tea catechin beverage compared with the placebo beverage [132]. Katada et al concluded that ingestion of tea catechin along with caffeine for 2 weeks increases thermogenesis and EE immediately after ingestion of the test beverage.…”

“…However, other studies that used randomized controlled trial (RCT) designs did yield similar results. A single-blind, RCT conducted in individuals with obesity found a significant decrease in body weight and waist circumference over 8 weeks of supplementation with a green tea beverage that contained EGCG and caffeine as compared to a placebo beverage [132].…”

Aframomum melegueta Seed Extract with Standardized Content of 6-Paradol Reduces Visceral Fat and Enhances Energy Expenditure in Overweight Adults – A Randomized Double-Blind, Placebo-Controlled Clinical Study

“… 8 Recently, Caffeine was demonstrated to enhance the physical activity-driven caloric cost in rats. 9 Recently Katada et al 10 reported that a 2-week consumption of catechins with caffeine markedly increased the energy expenditure in middle-aged human subjects. Use of such thermogenic agents is a promising strategy to mitigate obesity and associated metabolic diseases.…”