Daily consumption of a mangosteen‐based drink improves in vivo antioxidant and anti‐inflammatory biomarkers in healthy adults: a randomized, double‐blind, placebo‐controlled clinical trial

Abstract

Mangosteen (Garcinia mangostana) is a tropical fruit cultivated mainly in Southeast Asia. Recent studies have shown mangosteen has many health benefits. In this study, we aimed to determine the effects of a mangosteen-based beverage on antioxidant and anti-inflammatory and immunity biomarkers in plasma of healthy adults. A randomized, double-blind, placebo-controlled clinical trial was conducted using 60 participants, 30 men, and 30 women, ages 18–60. Participants were randomly divided into two groups, placebo and mangosteen groups, with the same number of male and female participants in each group. The trial duration was 30 days. ORAC as an antioxidant biomarker was measured in both groups. It was found that after the 30-day trial, the group given the mangosteen-based drink formula showed 15% more antioxidant capacity in the bloodstream than did the placebo group. As for the inflammatory biomarkers, in the mangosteen group, between the preintervention and postintervention, the C-reactive protein level significantly decreased by 46%, while no significant decreases for the same biomarker was observed in the placebo group. Immunity biomarkers IgA, IgG, IgM, C3 and C4 were not affected in either group. In addition, the effects on hepatic function (Aspartate Aminotransferase and Alanine Aminotransferase) and kidney function (creatinine) were investigated. Our results indicated that after the 30-day consumption of the beverage, there were no side effects on human hepatic and kidney functions. The outcome of this study showed that the mangosteen-based formula significantly increases antioxidant capacity and possesses anti-inflammatory benefits with no side effects on immune, hepatic, and renal functions for long-term consumption.

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“…Additionally, active research should also be directed at novel drug formulation and delivery systems, such as solid dispersion and nanoparticle formulations of α-MG, which would enhance its targeting effect, bioavailability, and efficacy. Anyway, the current available preclinical and mechanistic ▶ Decreased levels of serum CRP levels; enhanced antioxidant capacity; immunity biomarkers IgA, IgG, IgM, C3 and C4 were not affected; no side effects on human hepatic and kidney functions [134] data has indicated that α-MG is a promising candidate to be used in cancer chemoprevention.…”

“…Additionally, Chitchumroonchokchai et al [133] revealed the presence of free and conjugated forms of α-MG in plasma and urine after consuming a mangostin-rich mangosteen juice. In a recent randomized, double-blind, placebo-controlled clinical trial, the investigators examined the effects of a mangosteenbased beverage (Verve ® ) on antioxidant, anti-inflammatory, and immunity biomarkers in the plasma of healthy adults [134]. It was found that after the 30-day trial, the CRP level in the group given the mangosteen-based drink formula significantly decreased by 46 %, and that antioxidant capacity in the bloodstream showed 15 % more than that in the placebo group.…”

Review ofGarcinia mangostanaand its Xanthones in Metabolic Syndrome and Related Complications

“…In another study, orally 40 mg/kg α‐mangostin decreased the level of COX‐2 and Il‐6 induced by LPS in mouse brain (Nava Catorce et al, ). Significant elevation in antioxidant capacity in the blood stream and reduced inflammatory markers such as C‐reactive protein by 46% have been shown by daily consumption of a mangosteen‐based drink for 30 day in healthy adult (Xie et al, ). In pilot, dose‐finding study on 122 overweight and obese persons, who take mangosteen juice blend (XanGoJuice™) in high dose (18 oz.…”

Syntheses of (+)-30-epi-, (−)-6-epi-, (±)-6,30-epi-13,14-Didehydroxyisogarcinol and (±)-6,30-epi-Garcimultiflorone A Utilizing Highly Diastereoselective, Lewis Acid-Controlled Cyclizations

“…8m Interestingly, isogarcinol ( 1 ) is also available for human consumption in mangosteen drinks and capsules as a remedy for arthritis. 9 Only one total synthesis of 1 has been reported since its isolation in 1980, an elegant strategy accomplished in 15 steps by Pleitker and co-workers. 10,11a The compound has been isolated from numerous sources, 11 and a large scale extraction procedure was developed for its procurement.…”