Daily Branched‐Chain Amino Acid Intake and Risks of Obesity and Insulin Resistance in Children: A Cross‐Sectional Study

Lü, Jun; Gu, Yuying; Liu, Huikun; Wang, Leishen; Li, Wei; Li, Weiqin; Leng, Junhong; Zhang, Shuang; Qi, Lü; Yang, Xilin; Hu, Gang

doi:10.1002/oby.22834

Cited by 30 publications

(26 citation statements)

References 31 publications

(38 reference statements)

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“…Earlier studies have found a positive association between plasma levels of BCAAs and visceral adipose tissue (VAT) and insulin resistance (8,9). A cross-sectional study in China reported that children of mothers with GDM who had higher intake of BCAAs had higher odds of overweight and insulin resistance (11). In addition, in an experimental study, restriction of dietary BCAAs resulted in weight loss and improved glucose tolerance and insulin sensitivity in diet-induced obese mice (21).…”

Section: Discussionmentioning

confidence: 96%

“…Some studies have revealed that dietary intake of BCAAs was associated with increased circulating levels of these amino acids (10). Lu et al in a cross-sectional study investigated that increased BCAAs intake is associated with increased risk of insulin resistance and obesity in children (11). Conversely, dietary branched-chain amino acids have been associated with a lower prevalence of overweight and obesity in some other studies (12,13).…”

Section: Introductionmentioning

confidence: 99%

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Dietary intake of branched-chain amino acids in relation to general and abdominal obesity

et al. 2021

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Purpose: Despite the huge evidence on the link between dietary protein intake and obesity, limited studies have examined the role of individual amino acids in this regard. This study aimed to investigate the association between dietary total and individual BCAAs intake and odds of general and abdominal obesity in a large group of adults. Methods: This cross-sectional study was conducted among 8691 adults aged 18-55 years in Isfahan, Iran. Dietary BCAAs were assessed using a validated dish-based 106-item semi-quantitative food frequency questionnaire (DS-FFQ). Information about weight and waist circumference were collected through a self-reported validated questionnaire. General obesity was de ned as body mass index (BMI) ≥30 kg/m 2 , and abdominal obesity was de ned as waist circumference (WC) ≥88 cm for women and ≥102 cm for men.Results: Mean age of study participants was 36.8±8.1 years. Prevalence of general obesity was 9.2% in men and 9.7% in women and that of abdominal obesity was 13.3% and 36.2% in men and women, respectively. We found that participants in the top tertile of total BCAAs intake had higher odds of general obesity compared with those in the bottom tertile (OR: 1.42; 95% CI: 1.09-1.84). Such signi cant association was seen in men (OR: 1.57; 95% CI: 1.05-2.34), but not in women (OR: 1.33; 95% CI: 0.94-1.89) in our strati ed analysis. We found no signi cant association between total BCAAs intake and odds of abdominal obesity. Strati ed by sex, no signi cant association was observed between total BCAAs intake and odds of abdominal obesity [

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Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Dietary intake of branched-chain amino acids in relation to general and abdominal obesity

et al. 2021

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“…BCAAs, namely, leucine, isoleucine, and valine, are a cluster of essential amino acids that can be taken up by skeletal muscle and used for energy, muscle repair, or building (Kimball & Jefferson, 2006). However, emerging evidence suggests that inappropriately high levels of circulating BCAAs is of relevance to increased risks for overweight, insulin resistance, and T2DM (Lu et al., 2020; Neis, Dejong, & Rensen, 2015; Wolak‐Dinsmore et al., 2018). Therefore, prevention or mitigation of MetS by means of modulating BCAAs levels has become a research hotspot (Meslier et al., 2020).…”

Section: Protective Effects Of Cfs/metabolites On the Intestinal Barrmentioning

confidence: 99%

Citrus flavonoids and the intestinal barrier: Interactions and effects

Wang

Zhao

Wen

et al. 2020

Comp Rev Food Sci Food Safe

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The intestinal barrier plays a central role in sustaining gut homeostasis and, when dysfunctional, may contribute to diseases. Dietary flavonoids derived from Citrus genus represent one of the main naturally occurring phytochemicals with multiple potential benefits for the intestinal barrier function. In the intestine, citrus flavonoids (CFs) undergo ingestion from the lumen, biotransformation in the epithelial cells and/or crosstalk with luminal microbiota to afford various metabolites that may in turn exert protective actions on gut barrier along with their parental compounds. Specifically, the health‐promoting properties of CFs and their metabolic bioactives for the intestinal barrier include their capacity to (a) modulate barrier permeability; (b) protect mucus layer; (c) regulate intestinal immune system; (d) fight against oxidative stress; and (e) positively shape microbiome and metabolome. Notably, local effects of CFs can also generate systemic benefits, for instance, improvement of gut microbial dysbiosis helpful to orchestrate gut homeostasis and leading to alleviation of systemic dysmetabolism. Given the important role of the intestinal barrier in overall health, further understanding of underlying action mechanisms and ultimate health effects of CFs as well as their metabolites on the intestine is of great significance to future application of citrus plants and their bioactives as dietary supplements and/or functional ingredients in medical foods.

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“…Branched‐chain amino acids (BCAAs), such as isoleucine, leucine and valine, play a vital role in regulating glycolipid metabolism (Lu et al., 2020). Elevated levels of BCAAs have been shown to be associated with insulin resistance and glucose intolerance (Lynch & Adams, 2014).…”

Section: Resultsmentioning

confidence: 99%

Enteromorpha prolifera polysaccharide prevents high‐ fat diet‐induced obesity in hamsters: A NMR‐based metabolomic evaluation

Guo

Han

Song

et al. 2021

Journal of Food Science

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Enteromorpha prolifera polysaccharide (EP) has been shown to exhibit hypolipidemic and hypoglycemic activities in various experimental models.Here, an 1 H-NMR-based metabolomic study was conducted to explore the regulatory effects of EP on serum metabolic changes in obese hamsters. High-fat diet (HFD)-fed hamsters were orally administrated with EP (300, 450, or 600 mg/kg) once daily for 12 weeks. Compared with HFD-fed hamsters, EP treatment (450 and 600 mg/kg) significantly decreased the body weight (by 8.69 and 8.24%), liver weight (by 7.87 and 8.25%), epididymal white adipose tissue (by 19.54 and 17.26%), perirenal white adipose tissue (by 28.09 and 28.94%), serum total cholesterol (by 24.31 and 18.61%), triglyceride (by 30.64 and 31.38%), and low-density lipoprotein cholesterol (by 38.26 and 36.30%), respectively. In addition, EP intervention also significantly decreased hepatic cholesterol (by 23.20, 38.16, and 34.57%) and triglyceride content (by 17.78, 41.47, and 35.50%) as well as serum levels of alanine aminotransferase (ALT) and ALT/aspartate aminotransferase (AST) ratio. The serum samples of normal diet (ND) group, HFD group and HFD + EP 450 mg/kg (HFD + MEP) group were further analyzed by 1 H-NMR spectroscopy. Compared with ND group, 17 and 2 metabolites were significantly upregulated and downregulated in HFD group, respectively. Interestingly, EP treatment significantly downregulated nine metabolites and upregulated one metabolite when compared to those in HFD group. Our results indicated that EP intervention partially ameliorated HFD-induced metabolic dysfunction, and the most prominent metabolic pathways included citrate cycle, synthesis and degradation of ketone bodies, pyruvate metabolism, valine, leucine and isoleucine degradation, and arginine biosynthesis. Practical Application: Enteromorpha prolifera polysaccharide (EP), the main active component of Enteromorpha prolifera, is reported to have many biological activities. However, the antiobesity effect of EP and its corresponding metabolic mechanism have not been reported so far. The results of this study confirmed the antiobesity effect of EP on HFD-induced obese hamsters and elucidated its possible metabolic mechanism. Our study highlighted that EP might be used in weight-loss functional foods.

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Daily Branched‐Chain Amino Acid Intake and Risks of Obesity and Insulin Resistance in Children: A Cross‐Sectional Study

Cited by 30 publications

References 31 publications

Dietary intake of branched-chain amino acids in relation to general and abdominal obesity

Dietary intake of branched-chain amino acids in relation to general and abdominal obesity

Citrus flavonoids and the intestinal barrier: Interactions and effects

Enteromorpha prolifera polysaccharide prevents high‐ fat diet‐induced obesity in hamsters: A NMR‐based metabolomic evaluation

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