Daily bilateral pudendal nerve electrical stimulation improves recovery from stress urinary incontinence

Deng, Kangli; Balog, Brian; Lin, Dan; Hanzlicek, Brett; Song, Qixiang; Zhu, Hui; Damaser, Margot S.

doi:10.1098/rsfs.2019.0020

Cited by 14 publications

(17 citation statements)

References 35 publications

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“…In our studies three TENS episodes were enough to significantly decrease the signs of urinary incontinence in the VD rats. This finding suggests that this method has similar results to multiple stimulations of the PDN to improve urethral function and accelerate recovery from stress urinary incontinence after childbirth injury model in rats 10 . Multiple TENS of the DNC and electrical stimulations of the PDN, could serve as possible regenerative therapies for women with postpartum urinary incontinence and to alleviate this urinary pathology later in life.…”

Section: Discussionmentioning

confidence: 59%

“…Similarly, in a combinatory injury of VD and pudendal nerve (PDN) crush in rats, 1 h of electrical stimulation of the PDN (20 Hz, 0.3 mA, 0.1-ms pulse), proximal to the crushed region, increased expression of BDNF and βII-tubulin in EUS motoneurons 8,9 , suggesting that electrical nerve stimulation induces neuro-regenerative processes of the EUS neural circuitry after childbirth-like trauma. Multiple treatments of electrical stimulation appear to further accelerate recovery in this same model 10 . However, electrical stimulation of the PDN is invasive.…”

Section: Introductionmentioning

confidence: 77%

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Time course for urethral neuromuscular reestablishment and its facilitated recovery by transcutaneous neuromodulation after simulated birth trauma in rats

Palacios-Galicia

Juarez

Mirto-Aguilar

et al. 2021

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The aims of the study were to determine the time-course of urinary incontinence recovery after vaginal distension (VD), elucidate the mechanisms of injury from VD leading to external urethral sphincter (EUS) dysfunction, and assess if transcutaneous electrical stimulation (TENS) of the dorsal nerve of the clitoris facilitates recovery of urinary continence after VD. Rats underwent 4-h VD, 4-h sham VD (SH-VD), VD plus 1-h DNC TENS, and VD plus 1-h sham TENS (SH-TENS). TENS or SH-TENS were applied immediately and at days 2 and 4 post-VD. Micturition behavior, urethral histochemistry and histology, EUS and nerve electrophysiology, and cystometrograms were evaluated. VD induced urine leakage and disrupted EUS fibers and nerve-conduction. Urine leakage disappeared 13 days post-VD. Structural and functional recovery of the EUS neuromuscular circuitry started by day 6 post-VD but did not fully recovered by day 11 post-VD. TENS significantly decreased the frequency of urine leakage post-VD (p<0.01). We conclude that rat urinary continence function after VD requires 2 weeks to recover, although urethra structure is not fully recovered. Treatment to facilitate neuroregeneration should be applied within one-week after damage. TENS facilitated urinary continence recovery after VD. This treatment may have potential to decrease postpartum urinary incontinence in women.

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Section: Discussionmentioning

confidence: 59%

Section: Introductionmentioning

confidence: 77%

Time course for urethral neuromuscular reestablishment and its facilitated recovery by transcutaneous neuromodulation after simulated birth trauma in rats

Palacios-Galicia

Juarez

Mirto-Aguilar

et al. 2021

Preprint

Self Cite

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“… 29 Additionally, stimulation of pudendal nerves can contract the pelvic floor muscle and simulate PFMT, 30 which can improve urethral function and relieve SUI symptoms. 31 …”

Section: Discussionmentioning

confidence: 99%

“…29 Additionally, stimulation of pudendal nerves can contract the pelvic floor muscle and simulate PFMT, 30 which can improve urethral function and relieve SUI symptoms. 31 Since a lot of Chinese have received acupuncture before, superficial insertion at non-acupuncture point area with minimal and transient electric current is applied as sham control to eliminate placebo effects. The superficial insertion enables participants to perceive the stimulation and electric current promptly, and the transient electric current can enhance the blinding even if it lasts only about 30 s. It is argued that minimal acupuncture may evoke physiological effects, 32 especially for pain and depression.…”

Section: Discussionmentioning

confidence: 99%

Electroacupuncture for stress-predominant mixed urinary incontinence: a protocol for a three-armed randomised controlled trial

et al. 2021

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IntroductionEvidence specific for stress-predominant mixed urinary incontinence is still lacking at present, and acupuncture may relieve the symptoms. We plan to conduct this multi-centre, three-armed, randomised controlled trial to investigate the efficacy and safety of electroacupuncture among women with stress-predominant mixed urinary incontinence.Methods and analysisThe trial will be conducted at five hospitals in China. Two hundred thirty-two eligible women will be randomly assigned (2:1:1) to the electroacupuncture, sham electroacupuncture or waiting-list group to receive either 24-session acupuncture/sham acupuncture treatment over 8 weeks and 24-week follow-up or 20-week watchful waiting. The primary outcome is the proportion of participants with at least 50% reduction in mean 24-hour stress incontinence episode frequencies from baseline to week 8. The outcome will be analysed with the intention to treatpopulation (defined as participants randomised) with a two-sided p value of less than 0.05 considered significant.Ethics and disseminationThe protocol has been approved by Guang’anmen Hospital Institutional Review Board (2019-241-KY). Detailed information of the trial will be informed to the participants, and written informed consent will be obtained from every participant. Results of the trial are expected to be published in a peer-reviewed journal.Trial registration numberClinicalTrials.gov Registry (NCT04299932).

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“…The articles by Deng et al [8] and Kriete et al [9] examine potential novel treatments for SUI. Deng et al investigate increasing electrical stimulation of the pudendal nerve bilaterally as a treatment in rat models of SUI.…”

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confidence: 99%

Bioengineering in women's health: part I

2019

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This theme issue of Interface Focus is the first of two sets of articles on the topic of bioengineering in women's health. Although there is a long history of collaboration between engineers and medical professionals in orthopaedics and cardiovascular medicine, there has been growing interest in the last decade for interdisciplinary collaborations in other areas of medical science. This growth is particularly true in the case of women's health, a traditionally underserved area of research in the scientific community where fundamental knowledge of female physiology is still needed. Women's health is a broad category encompassing reproduction, fertility, maternal health, normal and abnormal pregnancy and the sequelae associated with a difficult childbirth. Women's health also includes sex-associated pathology associated with cancer, pain, cardiac disease, osteoporosis and other diseases. This list is not exhaustive with new scientific frontiers developing based on the evolving discourse of medicine for all. This first issue in the series focuses on bioengineering advances in the study of the non-pregnant woman, and the articles highlight important developments in pelvic floor disorders, biomedical devices, fertility, breast implant failure and breast cancer. The second issue in the series focuses on pregnancy.

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Daily bilateral pudendal nerve electrical stimulation improves recovery from stress urinary incontinence

Cited by 14 publications

References 35 publications

Time course for urethral neuromuscular reestablishment and its facilitated recovery by transcutaneous neuromodulation after simulated birth trauma in rats

Time course for urethral neuromuscular reestablishment and its facilitated recovery by transcutaneous neuromodulation after simulated birth trauma in rats

Electroacupuncture for stress-predominant mixed urinary incontinence: a protocol for a three-armed randomised controlled trial

Bioengineering in women's health: part I

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