Daidzein Ameliorates Dextran Sulfate Sodium-Induced Experimental Colitis in Mice by Regulating NF-κB Signaling

Shen, Jiangli; Li, Na; Zhang, Xi

doi:10.1615/jenvironpatholtoxicoloncol.2018027531

Cited by 20 publications

(11 citation statements)

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“…In present study, dietary daidzein significantly down-regulated the gene expression of proinflammatory cytokine TNF-α and up-regulated the expression of anti-inflammatory cytokine TGF-β. These results were consistent with the study on DSS-induced colitis mouse model, which showed oral administration of daidzein ameliorated the ulcerative colitis and suppressed the expression of TNF-α, interleukin-1β (IL-1β), and IL-6 22 . The decreased gene expression of pro-inflammatory cytokines responded to daidzein was also found in intestine of turbot fed with fish meal-based diet 27 .…”

Section: Discussionsupporting

confidence: 91%

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The protective role of daidzein in intestinal health of turbot (Scophthalmus maximus L.) fed soybean meal-based diets

Liu

et al. 2021

Sci Rep

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Soybean meal-induced enteropathy (SBMIE) is prevalent in aquaculture. The aim of this study is to evaluate the role of daidzein on SBMIE of juvenile turbot (Scophthalmus maximus L.) by feeding with fish meal diet (FM), soybean meal diet (SBM, 40% fish meal protein in FM replaced by soybean meal protein) and daidzein diet (DAID, 40 mg/kg daidzein supplemented to SBM) for 12 weeks. We found that daidzein supplementation elevated the gene expression of anti-inflammatory cytokine TGF-β, decreased gene expression of pro-inflammatory cytokines TNF-α and signal molecules p38, JNK and NF-κB. SBM up-regulated the genes expression related to oxidative stress and apoptosis, but dietary daidzein restored it to the similar level with that in FM group. Moreover, dietary daidzein up-regulated gene expression of tight junction protein, and modified the intestinal microbial profiles with boosted relative abundance of phylum Proteobacteria and Deinococcus–Thermus, genera Sphingomonas and Thermus, species Lactococcus lactis, and decreased abundance of some potential pathogenic bacteria. In conclusion, dietary daidzein could ameliorate SBM-induced intestinal inflammatory response, oxidative stress, mucosal barrier injury and microbiota community disorder of turbot. Moreover, p38, JNK and NF-κB signaling might be involved in the anti-inflammatory process of daidzein, and daidzein itself might act as an antioxidant to resist SBM-induced oxidative damage.

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Section: Discussionsupporting

confidence: 91%

“…The decreased gene expression of pro-inflammatory cytokines responded to daidzein was also found in intestine of turbot fed with fish meal-based diet 27 . It has been reported that many signaling pathways are involved in the anti-inflammatory effects of daidzein, of which MAPK and NF-κB are the most deeply studied 21,22,29 .…”

Section: Discussionmentioning

confidence: 99%

The protective role of daidzein in intestinal health of turbot (Scophthalmus maximus L.) fed soybean meal-based diets

Liu

et al. 2021

Sci Rep

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“…Additionally, the decomposed product of uracil was β-alanine, which could further synthesize propionate ( West et al., 1985 ), which might explain the positive correlation between uracil and lactose. Deltonin and daidzein were reported to have antitumor activity and inhibit inflammatory factors in serum ( Tong et al., 2011 ; Shen et al., 2019 ). The negative correlation between deltonin, daidzein and milk SCC might reveal the enhancement of immune and disease resistance in dairy cows.…”

Section: Discussionmentioning

confidence: 99%

Dietary supplementation with inulin improves lactation performance and serum lipids by regulating the rumen microbiome and metabolome in dairy cows

et al. 2021

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This study investigated the effects of inulin on rumen fermentation parameters, ruminal microbiome and metabolites, as well as lactation performance and serum indexes in dairy cows. Sixteen Holstein dairy cows with similar body conditions were randomly divided into 2 groups ( n = 8 per group), with inulin addition at 0 and 200 g/d per cow. The experiment lasted for 6 weeks, including a 1-week adaptation period and a 5-week treatment period. At the end of the experimental period, the milk, serum and rumen fluid were sampled and analyzed. The microbiome and metabolome in the rumen fluid were analyzed via 16S rRNA sequencing and untargeted metabolomics, respectively. The results showed that supplementation with inulin (200 g/d per cow) increased the milk yield ( P = 0.001), milk protein ( P = 0.032), lactose rate ( P = 0.004) and proportion of saturated fatty acids (SFA) in milk ( P < 0.001), but decreased the proportion of unsaturated fatty acids (USFA) ( P = 0.041). Rumen pH ( P = 0.040) and the concentration of NH 3 –N ( P = 0.024) were decreased; however, acetate ( P < 0.001), propionate ( P = 0.003), butyrate ( P < 0.001) and lactic acid (LA) ( P = 0.043) were increased. The total cholesterol (TC) ( P = 0.008) and triglycerides (TG) ( P = 0.01) in serum were also reduced. Additionally, inulin addition elevated the relative abundance of several beneficial symbiotic and short-chain fatty acid (SCFA)-producing bacteria, such as Muribaculaceae (false discovery rate [FDR]-adjusted P < 0.01), Acetitomaculum (FDR-adjusted P = 0.043), and Butyrivibrio (FDR-adjusted P = 0.036), while elevating the levels of L-lysine (FDR-adjusted P = 4.24 × 10 −3 ), L-proline (FDR-adjusted P = 0.0158), and L-phenylalanine (FDR-adjusted P = 0.027). In contrast, several pathogens and ruminal bacteria abundant in high-fat diets, such as Escherichia-Shigella (FDR-adjusted P = 0.022), Erysipelotrichaceae __UCG-004 (FDR-adjusted P < 0.01) and RF39 (FDR-adjusted P = 0.042) were decreased along with the reduction of lysophosphatidylcholine (LysoPC) (18:1 (9Z)) (FDR-adjusted P = 1.03 × 10 −3 ), LysoPC (16:0) (FDR-adjusted P = 0.0108), LysoPC (18:2 (9Z, 12Z)) (FDR-adjusted P = 1.65 × 10 −3 ) and 8-methylnonenoate. I...

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“…The gene expression of TNF-α, IL-6, and IL-1β was reduced in the GCJ group compared to the DSS group. In other colitis mouse models, TNF-α, IL-6, and IL-1β in serum and colon were reduced after administering doenjang , fermented soybean paste, and isoflavones such as daidzein and genistein, which are bioactive compounds of soybeans [ 9 , 20 , 21 , 38 , 39 ]. Some of the bioactive compounds of Gochujang made from meju (fermented soybean) are daidzein and genistein [ 12 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…Gochujang contains 5~11% salt, but its main bioactive compounds have been identified as capsaicin of red pepper powder, isoflavones of meju , and probiotics [ 12 , 17 , 18 ]. According to reports, these components help in alleviating colitis symptoms through their anti-inflammatory activities [ 19 , 20 , 21 , 22 , 23 , 24 , 25 ]. However, there is a lack of research on reducing signs and symptoms of colitis with Gochujang .…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Gochujang on Inflammation in a DSS-Induced Colitis Rat Model

Mahoro

Moon

Yang

et al. 2021

Foods

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Gochujang is a traditional Korean fermented soy-based spicy paste made of meju (fermented soybean), red pepper powder, glutinous rice, and salt. This study investigated the anti-inflammatory effects of Gochujang containing salt in DSS-induced colitis. Sprague–Dawley (SD) rats were partitioned into five groups: normal control, DSS control, DSS + salt, DSS + mesalamine, and DSS + Gochujang groups. They were tested for 14 days. Gochujang improved the disease activity index (DAI), colon weight/length ratio, and colon histomorphology, with outcomes similar to results of mesalamine administration. Moreover, Gochujang decreased the serum levels of IL-1β and IL-6 and inhibited TNF-α, IL-6, and IL-1β mRNA expression in the colon. Gochujang downregulated the expression of iNOS and COX-2 and decreased the activation of NF-κB in the colon. Gochujang induced significant modulation in gut microbiota by significantly increasing the number of Akkermansia muciniphila while decreasing the numbers of Enterococcus faecalis and Staphylococcus sciuri. However, compared with the DSS group, the salt group did not significantly change the symptoms of colitis or cytokine levels in serum and colon. Moreover, the salt group significantly decreased the gut microflora diversity. Gochujang mitigated DSS-induced colitis in rats by modulating inflammatory factors and the composition of gut microflora, unlike the intake of salt alone.

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Daidzein Ameliorates Dextran Sulfate Sodium-Induced Experimental Colitis in Mice by Regulating NF-κB Signaling

Cited by 20 publications

References 0 publications

The protective role of daidzein in intestinal health of turbot (Scophthalmus maximus L.) fed soybean meal-based diets

The protective role of daidzein in intestinal health of turbot (Scophthalmus maximus L.) fed soybean meal-based diets

Dietary supplementation with inulin improves lactation performance and serum lipids by regulating the rumen microbiome and metabolome in dairy cows

Protective Effect of Gochujang on Inflammation in a DSS-Induced Colitis Rat Model

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