Dacron or ePTFE for Femoro-popliteal Above-Knee Bypass Grafting: Short- and Long-term Results of a Multicentre Randomised Trial

Abstract

During prolonged follow-up (10 years), Dacron femoro-popliteal bypass grafts have superior patency compared to those of ePTFE grafts. Dacron is the graft material of choice if the saphenous vein is not available.

Detergent-Enzymatic Decellularization of Swine Blood Vessels: Insight on Mechanical Properties for Vascular Tissue Engineering

“…Another option is represented by the use of synthetic grafts, which allow positive outcomes when used in large diameter vessels substitution but often lead to the failure of the implant due to thrombotic phenomena or intimal hyperplasia when applied in small caliber ones [2]. The mechanical behavior of the implant was proven to be one of the main causes of lumen occlusions because of compliance mismatch between the native vessel and the synthetic graft [3, 4]; in order to compensate for the mechanical difference, an in vivo remodeling occurs leading to progressive vessel wall thickening, until complete occlusion. Furthermore, mechanical mismatching could generate nonphysiological blood flows encouraging the formation of thrombi or aneurysms.…”

Combination therapy with warfarin plus clopidogrel improves outcomes in femoropopliteal bypass surgery patients

“…Moreover, while for BK outflow site there is no doubt that the saphenous vein represents the first choice, 2 many studies have addressed the good results with AK prosthetic Dacron bypass as a simple and straightforward procedure. 25,26 Study end points and definitions. Coprimary study end points were graft patency, defined as an ABPI Ն 0.9 with a duplex ultrasound graft scan examination that showed velocities of more than 30 cm/s and Ͻ150 cm/s, and the absence of severe peripheral arterial ischemia threatening the viability of the limb and leading to amputation.…”

The performance of a small-calibre graft for vascular reconstructions in a senescent sheep model

“…Whilst a number of prosthetic grafts have been successfully developed for the replacement of large-calibre (>6 mm) vessels, the small-calibre (<6 mm) counterparts fail due to thrombosis and intimal hyperplasia (IH) [3]. The two most common prosthetic grafts used clinically are produced from polyethylene terephthalate (PET) and expanded polytetrafluoroethylene (ePTFE).…”