D1 receptors involved in the acquisition of sexual experience in male rats

Bialy, Michał; Kalata, Urszula; Nikolaev-Diak, Anna; Nikolaev, Evgeni

doi:10.1016/j.bbr.2009.09.008

Cited by 22 publications

(29 citation statements)

References 64 publications

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“…Given that sexual input increases DA and glutamate release in the MPOA (Dominguez, Gil, & Hull, 2006; Hull et al ., 1995), and stimulates phosphorylation of glutamate NMDA receptors (Dominguez et al ., 2007), they may also work together to promote sexual learning. Indeed, systemic administration of a D 1 or NMDA receptor antagonist impairs the acquisition of sexual experience (Bialy et al, 2010; Bialy, Rydz, & Kaczmarek, 2000) and blocking NMDA receptors in the MPOA can impair the enhancement that would otherwise have resulted from repeated noncopulatory exposures to an estrous female (Vigdorchik et al, 2012). However, it is not known whether D 1 and NMDA receptors also interact in the MPOA to mediate sexual learning, although these and previous data demonstrate that, when tested separately, both play a role in the enhancement of copulation following repeated female exposures.…”

Section: Discussionmentioning

confidence: 99%

Dopamine D1 receptors and phosphorylation of dopamine- and cyclic AMP-regulated phosphoprotein-32 in the medial preoptic area are involved in experience-induced enhancement of male sexual behavior in rats.

McHenry¹,

Bell²,

Parrish³

et al. 2012

Behavioral Neuroscience

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The medial preoptic area (MPOA) is an integral site for male sexual behavior. Dopamine is released in the MPOA before and during copulation and facilitates male rat sexual behavior. Repeated sexual experience and noncopulatory exposures to an estrous female facilitate subsequent copulation. However, the neurobiological mechanisms that mediate such enhancement remain unclear. Here, we examined the role of dopamine D1 receptors in the MPOA in experience-induced enhancement of male sexual behavior in rats. In Experiment 1, microinjections of the D1 antagonist SCH-23390 into the MPOA before each of 7 daily 30-min noncopulatory exposures to a receptive female impaired copulation on a drug-free test on day 8, compared to vehicle-treated female-exposed animals. Copulatory performance in drug-treated animals was similar to vehicle-treated males that had not been pre-exposed to females. This effect was site specific. There were no group differences in locomotor activity in an open field on the copulation test day. In Experiment 2, a separate cohort of animals was used to examine phosphorylation of dopamine-and cAMP-regulated phosphoprotein (DARPP-32) in the MPOA of animals with acute and/or chronic sexual experience. DARPP-32 is a downstream marker of D1 receptor signaling and substrate of cAMP-dependent protein kinase (PKA). Western immunoblot analysis revealed that p-DARPP-32 expression was greatest in the MPOA of males that received both acute and chronic sexual experience, compared to all other mated conditions and naïve controls. These data suggest that D1 receptors in the MPOA contribute to experience-induced enhancement of male sexual behavior, perhaps through a PKA regulated mechanism.

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Section: Discussionmentioning

confidence: 99%

Dopamine D1 receptors and phosphorylation of dopamine- and cyclic AMP-regulated phosphoprotein-32 in the medial preoptic area are involved in experience-induced enhancement of male sexual behavior in rats.

McHenry¹,

Bell²,

Parrish³

et al. 2012

Behavioral Neuroscience

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“…Unfamiliar females rats typically induce increased male sexual arousal (Wilson et al 1963) and increase dopamine release in the NAc (Fiorino et al 1997). Several lines of evidence suggest that dopamine receptors (including D1 receptors specifically) in the NAc facilitate male sexual motivation in rats (Everitt et al 1989; Pfaus and Phillips 1991; Liu et al 1998; Bialy et al 2010) but see (Moses et al 1995). Thus, species differences in social organization are associated with divergent effects of dopamine receptors on male behavioral responses to novel females.…”

Section: Introductionmentioning

confidence: 99%

Stress responses and the mesolimbic dopamine system: Social contexts and sex differences

Trainor

2011

Hormones and Behavior

118

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Organisms react to threats with a variety of behavioral, hormonal, and neurobiological responses. The study of biological responses to stress has historically focused on the hypothalamic-pituitary-adrenal axis, but other systems such as the mesolimbic dopamine system are involved. Behavioral neuroendocrinologists have long recognized the importance of the mesolimbic dopamine system in mediating the effects of hormones on species specific behavior, especially aspects of reproductive behavior. There has been less focus on the role of this system in the context of stress, perhaps due to extensive data outlining its importance in reward or approach-based contexts. However, there is steadily growing evidence that the mesolimbic dopamine neurons have critical effects on behavioral responses to stress. Most of these data have been collected from experiments using a small number of animal model species under a limited set of contexts. This approach has led to important discoveries, but evidence is accumulating that mesolimbic dopamine responses are context dependent. Thus, focusing on a limited number of species under a narrow set of controlled conditions constrains our understanding of how the mesolimbic dopamine system regulates behavior in response to stress. Both affiliative and antagonistic social interactions have important effects on mesolimbic dopamine function, and there is preliminary evidence for sex differences as well. This review will highlight the benefits of expanding this approach, and focus on how social contexts and sex differences can impact mesolimbic dopamine stress responses.

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“…This cannot exclude the effect of opioid receptor on PVs during acquisition of sexual experience, where drugs had an influence on the learning processes of rats which were sexually naïve at the beginning. Both NMDA and D1 receptors changed PVs during acquisition but not during performance in well-experienced males [12,23,63]. Our results have shown that a single injection of naltrexone or morphine did not change anticipatory precontact vocalizations which were established as the well-known rewarding value of sexual contact.…”

Section: Discussionmentioning

confidence: 41%

“…Previously, we found that PVs and EL changed simultaneously, and increasing PVs together with shortening EL are related to learning processes and require NMDA receptor activation [12]. Administration of D1 receptor agonists has shown that changes of PVs and EL are regulated by related but independent neural networks [23]. In the present experiment, we found that very high levels of precontact vocalizations can be observed in rats with low levels of copulatory efficiency (long EL).…”

Section: Discussionmentioning

confidence: 66%

“…As we reported previously, male rats with sexual experience vocalized within the 50-kHz range before a female was introduced into the copulatory arena (precontact vocalizationsPVs), whereas sexually naïve males initially vocalize only occasionally until after a few sexual contacts, with simultaneous shortening of ejaculation latency (EL) [12]. An increase in the number of 50-kHz calls was related to conditioning to odor cues from females, depending on the rewarding value of sexual contact, corresponding to learning processes that involve NMDA [12] and D1 receptor activation [23]. After ejaculation, male rats display postejaculatory 22-kHz vocalizations [24] simultaneously with sleep-like EEG [25].…”

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Sexual performance and precontact 50-kHz ultrasonic vocalizations in WAG/Rij rats: Effects of opioid receptor treatment

Bialy

Strefnel

Nikolaev-Diak

et al. 2014

Epilepsy & Behavior

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D1 receptors involved in the acquisition of sexual experience in male rats

Cited by 22 publications

References 64 publications

Dopamine D1 receptors and phosphorylation of dopamine- and cyclic AMP-regulated phosphoprotein-32 in the medial preoptic area are involved in experience-induced enhancement of male sexual behavior in rats.

Dopamine D1 receptors and phosphorylation of dopamine- and cyclic AMP-regulated phosphoprotein-32 in the medial preoptic area are involved in experience-induced enhancement of male sexual behavior in rats.

Stress responses and the mesolimbic dopamine system: Social contexts and sex differences

Sexual performance and precontact 50-kHz ultrasonic vocalizations in WAG/Rij rats: Effects of opioid receptor treatment

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