| c| = | u| = 1 processes are unique probes of flavor physics in the up-sector within and beyond the Standard Model (SM). SM tests with rare semileptonic charm meson decays are based on an approximate CP-symmetry, a superior GIM-mechanism, angular distributions, leptonuniversality and lepton flavor conservation. We analyze the complete set of null test observables in D → π ( ) and D s → K ( ) decays, ( ) = e, μ, and find large room for new physics safely above the SM contribution. We identify signatures of supersymmetry, leptoquarks and anomaly-free U (1) -models with generation-dependent charges, for which we provide explicit examples. Z -effects in c → u ( ) transitions can be sizable if both left-handed and right-handed couplings to quarks are present.