D-type fiber biosensor based on surface-plasmon resonance technology and heterodyne interferometry

Abstract

A D-type fiber biosensor based on surface-plasmon resonance (SPR) technology and heterodyne interferometry is presented. The sensing device is a single-mode optical fiber in which half the core is polished away and a thin-film layer of gold is deposited. We measure the phase-difference variations instead of the light intensity as in traditional SPR techniques. Therefore the accuracy and resolution of our method are very high. Its sensitivity can reach 2 x 10(-6) refractive-index units. The sensor has some merits, e.g., tunable high sensitivity, small size, lower cost, smaller sample volume, and suitability for in vivo testing. This novel method of a D-type fiber biosensor based on SPR technology and heterodyne interferometry is valuable for chemical, biological, and biochemical sensing, and the novel method of D-type fiber biosensing is a feasible means of study.

Phase‐sensitive surface plasmon resonance biosensors: methodology, instrumentation and applications

“…An advantage of this multiple reflection geometry over the conventional single reflection one consisted in a wider dynamic range. Experiments conducted on alcohol with variable concentrations showed a good agreement between simulations and experiment results [61]. Numerical simulations on 3-layer (glass core-goldsensing layer) [62] and 4-layer (glass core-silicon dioxidegold-sensing layer) [63] configurations of this D-type optical fiber sensor were carried out, and optimal parameters were suggested.…”

“…Optical heterodyning offers the third opportunity, which is based on the analysis of the differential frequency between two frequencyshifted orthogonally polarized s-and p-components of light reflected under SPR. Similarly to temporally modulated polarimetry, this approach makes possible an efficient noise removal and phase treatment tools [60][61][62][63][64][65][66], while its imaging prospects look more complicated. It is important that all three approaches are capable of providing much better sensitivities and related 1-2 order of magnitude lower detection limits.…”

“…Since 2005, Chiu and coworkers have reported a series of research works on the development of optical sensors based on the heterodyne detection [61][62][63]. Instead of using the prism coupler, their sensors were based on single mode optical fiber.…”

The Applications of the Heterodyne Interferoemetry

“…Because of the advantages of the optical method such as high sensitivity, high resolution, non-contact, and quick response, optical measurement method become more popular in past few decades. And these methods can roughly divide into fiber type sensor [41,[44][45]49] and non-fiber type sensor [42-43, 46-48, 50]. In this section, we will review some recent development in both type sensors for measuring concentration of the specific chemical compound [41][42][43][44][45][46][47][48][49][50].…”

Analytical sensitivity and reflected power through a D-shape optical fibre sensor

“…M.H. Chiu et al [7] have studied D−type fibre biosensor based on surface plasmon resonance technology and hetero− dyne interferometry. M. H. Fernandez−Valdivielso et al [8] have provided a general formulation for thermochronic− −effect−based temperature optical fibre sensor for underwa− ter applications.…”