D-Pinitol Increases Insulin Secretion and Regulates Hepatic Lipid Metabolism in Msg-Obese Mice

Abstract

D-pinitol is one of the major inositol found in plants and studies suggest its potential hypoglycemic and hypolipidemic actions in diabetic rodents. Here, we investigated the actions of D-pinitol on adiposity, and in lipid and glycemic homeostasis in monosodium glutamate (MSG)-obese mice. Swiss mice received daily subcutaneous injections of MSG [(4g/kg of body weight (BW)] or saline [1.25g/kg BW; control (CTL)] during their fi rst fi ve days of life. From 90-120 day-old, half of the MSG and CTL groups received 50 mg D-pinitol/kg BW/day (MPIN and CPIN groups) or vehicle (saline; MSG and CTL groups) by gavage. MSG mice displayed higher abdominal adiposity and hepatic triglycerides (TG) deposition, and increased hepatic expression of lipogenic genes (SREBP-1c, ACC-1 and FASN), but downregulation in AMPKα mRNA. MSG mice also exhibited hyperinsulinemia, islet hypersecretion and hypertrophy, glucose intolerance and insulin resistance. D-pinitol did not change adiposity, glucose intolerance, insulin resistance, but increased hepatic triglycerides (TG) content in MPIN mice, which was associated with increases in gene expressions of SREBP-1c and FASN, but reduction in AMPKα. Furthermore, D-pinitol enhanced insulin secretion in MPIN and CPIN groups. Therefore, D-pinitol enhanced glucose-induced insulin secretion, which may account to enhances hepatic lipogenesis and TG deposition in MPIN mice.

Pharmacological effects of D‐Pinitol – A comprehensive review

“…Silva Júnior et al (2020) studied the effectiveness of D‐PIN on hepatic lipid metabolism in obese Swiss albino mice. Monosodium glutamate (MSG) was administered (4 g/kg body weight) for 5 days to induce obesity in mice.…”

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“…It also has anti-allergic and anti-inflammatory properties 43 . 3-O-methyl-D-Chiro-Inositol is also called D-Pinitol, has substantial pharmacological importance; it has extensively used in the treatment of cancer, Alzheimer's disease, Type-2 Diabetes, and hepatoprotective activity 44,47 . D-Pinitol also Increases Insulin secretion and regulates hepatic lipid metabolism 48 .…”