D-optimal design as a useful tool response surface methodology for the optimization of signals from synchronous fluorescence prior to simultaneous determination of avanafil and tadalafil

Abdel-Raoof, Ahmed M.; Said, Ragab; Emara, Mohamed S.; El-Desouky, Ebrahim A.; Abdelzaher, Ahmed M.; Hasan, M. A.; Elsayed, Ayman Osman

doi:10.1016/j.saa.2020.118313

Cited by 14 publications

(11 citation statements)

References 40 publications

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“…Data results presented in Table 3 were in accordance with those produced by applying other reported methods for comparison. [ 13,37 ] Comparative statistical testing of the data results by Student’s t ‐test and the variance ratio F ‐test assured that there was no statistically significant difference between the adopted and other reported methods. The standard addition method was used to confirm the validity of the adopted method and indicated no matrix interference, as presented in Table 4.…”

Section: Methods Validation[51]mentioning

confidence: 98%

“…After adding a single dose of citalopram 40 mg, the maximum concentration (C max ) in plasma was 48.6 ng ml −1 at 2.4 h due to the rapid absorption of citalopram. [ 52 ] The C max for tadalafil was 378 μg ml −1 at 2 h after a single dose of tadalafil of 20 mg. [ 37 ] The high sensitivity of the adopted spectrofluorimetric method was successfully used to assay citalopram and tadalafil in spiked human plasma. Citalopram and tadalafil could be discriminated from other endogenous compounds without any interference.…”

Section: Methods Validation[51]mentioning

confidence: 99%

“…Various chromatographic, [ 22–28 ] spectrophotometric, [ 29–35 ] voltammetric [ 36 ] and spectrofluorimetric analytical methods have been applied for tadalafil determination. [ 37,38 ]…”

Section: Introductionmentioning

confidence: 99%

“…[ 46,47 ] The combination of SFS and experimental design can enhance the selectivity of SFS spectra. [ 37 ]…”

Section: Introductionmentioning

confidence: 99%

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Simultaneous determination of citalopram and tadalafil by the second derivative synchronous fluorescence method in biological fluids; application of Box–Behnken optimization design

et al. 2020

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This is the first study focusing solely on that determination of tadalafil in the presence of citalopram as an antidepressant drug. The determination in biological fluids of a co‐administered antidepressant drug and a sexual stimulation drug is a very critical and important step for psychotic and ischaemic heart disease patients, especially in cases of emergency and this requires therapeutic drug monitoring. A sensitive, efficient and rapid assay was selected satisfactorily and applied for simultaneous determination of citalopram and tadalafil either in their pure forms, in tablet dosage forms or in spiked human plasma. There was a large overlap for both drugs, forming the broad band found in conventional fluorescence spectra and their related synchronous fluorescence intensity. Therefore, the development of a highly sensitive second derivative synchronous fluorescence method was demonstrated that removed this overlap. The proposed method depended on measuring the amplitudes of the second derivative of synchronous fluorescence intensity at suitable wavelengths of 301 nm and 367 nm for citalopram and tadalafil at Δλ = 60 nm, respectively. Box–Behnken design as a response surface methodology was used to fit models and create an optimization process encompassing a set of factors and resulting in an optimum response value specifically designed for this method. Under optimum conditions, the linear dynamic ranges for citalopram and tadalafil estimation were 20–900 and 5–400 ng ml−1 with detection limits of 5.40 and 1.43 ng ml−1, respectively.

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Section: Methods Validation[51]mentioning

confidence: 98%

Section: Methods Validation[51]mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…[ 46,47 ] The combination of SFS and experimental design can enhance the selectivity of SFS spectra. [ 37 ]…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Simultaneous determination of citalopram and tadalafil by the second derivative synchronous fluorescence method in biological fluids; application of Box–Behnken optimization design

et al. 2020

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“…In a review paper, Hibbert [11] described the use of several DoE processes applied to chromatographic separation and highlighted the most used in optimization and validation studies such as: (1) Factorial design [12][13][14]; (2) Plackett-Burman (PB) design [15][16][17]; (3) Central Composite design (CCD) [18][19][20]; (4) Box-Behnken design (BBD) [21][22][23]; (5) Doehlert design (DD) [24][25][26] and (6) Mixture design [27][28][29]. Other types of DoE have been used and often cited in the literature, as examples Mixed-level fractional factorial design [30][31][32]; Definitive Screening design (DSD) [33][34][35] and D-optimal design [36][37][38].…”

Section: Introductionmentioning

confidence: 99%

Key information related to quality by design (QbD) applications in analytical methods development

Araujo¹,

Andrade²,

Babos³

et al. 2020

Braz. J. Anal. Chem.

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In this review, quality by design (QbD) initiatives are described as applications for many types of processes, such as in the pharmaceutical industry, biotechnology field, and for analytical methods development. Design space (DS) and design of experiments (DoE) provide useful results for analytical methods development and simulation of advanced processes in traditional manufacturing relationships. The three topics, QbD, DS and DoE are the best way to achieve strong and efficient industrial production.

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Environmentally benign first derivative synchronous spectrofluorimetry for the analysis of two binary mixtures containing duloxetine with avanafil or tadalafil in spiked plasma samples

Abd‐AlGhafar,

Abo Shabana,

El‐Shaheny

et al. 2024

Luminescence

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Antidepressants can cause sexual dysfunction side effects, necessitating the co‐administration of phosphodiesterase type 5 inhibitors. The simultaneous determination of these drugs in biological fluids is critical for therapeutic drug monitoring. For the first time, two binary mixtures containing duloxetine with either avanafil or tadalafil were estimated utilizing simple green spectrofluorimetric methods without the need for a previous separation step. The study was based on first derivative synchronous spectrofluorimetry in ethanol using a change in wavelength difference (∆λ) of 20 and 25 nm for the first and second combinations, respectively. Duloxetine and avanafil were estimated at 297.7 and 331 nm in their binary mixture, while duloxetine and tadalafil were determined at 290.3 and 297.7 nm, respectively. The linearity was achieved over the ranges of 0.1–1.5 μg mL−1 for both duloxetine and avanafil and 0.01–0.40 μg mL−1 for tadalafil, with limits of detection of 0.013, 0.022, and 0.004 μg mL−1 for duloxetine, avanafil, and tadalafil, respectively. Successful application of the developed approaches was accomplished for the estimation of the two mixtures in dosage forms as well as human plasma with excellent percentage recoveries (96–103.75% in plasma), which supports their suitability for use in quality control laboratories and pharmacokinetic studies. Moreover, the adopted approaches' greenness was evidenced by applying three tools.

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D-optimal design as a useful tool response surface methodology for the optimization of signals from synchronous fluorescence prior to simultaneous determination of avanafil and tadalafil

Cited by 14 publications

References 40 publications

Simultaneous determination of citalopram and tadalafil by the second derivative synchronous fluorescence method in biological fluids; application of Box–Behnken optimization design

Simultaneous determination of citalopram and tadalafil by the second derivative synchronous fluorescence method in biological fluids; application of Box–Behnken optimization design

Key information related to quality by design (QbD) applications in analytical methods development

Environmentally benign first derivative synchronous spectrofluorimetry for the analysis of two binary mixtures containing duloxetine with avanafil or tadalafil in spiked plasma samples

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