D‐lactic acidosis in lambs

Lorenz, I.; Lorch, A.

doi:10.1136/vr.164.6.174

Cited by 13 publications

(15 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In people, D‐hyperlactatemia induced encephalopathy is recognized with short bowel syndrome, and D‐lactate is suspected to be an important contributor to the high anion gap seen in diabetic ketoacidosis . Both D‐and L‐lactate are readily produced in ruminant species during the fermentation of carbohydrates by ruminal flora, and encephalopathy from D‐lactic acidosis is well‐documented due to grain overload, ruminal acidosis, calf diarrhea, drunken lamb syndrome, and floppy kid syndrome …”

Section: Pathophysiology–dyshomeostasis In Diseasementioning

confidence: 99%

Clinical use of plasma lactate concentration. Part 1: Physiology, pathophysiology, and measurement

Rosenstein

Tennent‐Brown

Hughes

2018

J Vet Emergen Crit Care

View full text Add to dashboard Cite

show abstract

Section: Pathophysiology–dyshomeostasis In Diseasementioning

confidence: 99%

Clinical use of plasma lactate concentration. Part 1: Physiology, pathophysiology, and measurement

Rosenstein

Tennent‐Brown

Hughes

2018

J Vet Emergen Crit Care

View full text Add to dashboard Cite

show abstract

“…Lorenz and Lorch (2009) describe the clinical signs observed in two lambs with LDLAS as somnolence, ataxia followed by recumbency and anorexia. One lamb was reported to be hypothermic (32.2°C) and had a slightly elevated respiratory rate (36 breaths/minute).…”

Section: Introductionmentioning

confidence: 99%

“…It is hypothesised that the source of the D-lactate is excessive rumenal or colonic fermentation (Ewaschuk and others 2004, Lorenz 2007) and D-lactic acidosis has been successfully treated with solutions of intravenous sodium bicarbonate in calves (Lorenz 2007), goat kids (Bleul and others 2006) and two lambs (Lorenz and Lorch 2009). This would suggest a role for an alkalinising agent in the treatment of LDLAS.…”

Section: Introductionmentioning

confidence: 99%

Successful correction of D‐lactic acid neurotoxicity (drunken lamb syndrome) by bolus administration of oral sodium bicarbonate

Angell¹,

Jones²,

Voigt³

et al. 2013

Veterinary Record

View full text Add to dashboard Cite

Drunken lamb syndrome (DLS) has recently been described as lamb D-lactic acidosis syndrome (LDLAS). In 2012, 18 lambs aged between 7 days and 28 days with LDLAS were identified. Biochemically, each lamb had a metabolic acidosis characterised by D-lactic acidosis and exhibited clinical signs including: not hyperthermic, no evidence of dehydration, demonstrating an ataxic gait tending to recumbency (DLS) and possibly somnolence. These lambs received 50 mmol of sodium bicarbonate as an 8.4 per cent solution given orally, together with parenteral long-acting amoxicillin. All 18 cases made a full clinical recovery. This study demonstrates a novel effective treatment for a disease that is usually fatal, and also demonstrates a strong correlation between venous plasma bicarbonate concentrations and venous plasma D-lactate concentrations (R(2)=0.49).

show abstract

“…The first report of D-lactic acidosis in lambs, by Lorenz and Lorch (2009), followed three years later; they concluded that far more work was required to unravel the cause.…”

mentioning

confidence: 99%

A practical approach to reducing losses due to drunken lamb syndrome

Lewis¹

2013

Veterinary Record

View full text Add to dashboard Cite

NeoNatal losses in lambs-particularly on occasions where much time and effort is spent striving to save them-have negative psychological effects on shepherds and also reduce the profitability of enterprises. Many conditions and diseases assail lambs during the first few weeks of life. Starvation and exposure account for a large proportion of deaths, as does clostridial disease, despite the availability of highly effective vaccines for the dam. losses that occur once lambs appear to be well bonded during the first two months of life are even more frustrating. a late or low infection rate of toxoplasmosis will produce weakly lambs which, despite intensive attention and support, usually die at about three to four days of age. again, vaccination of the dam can reduce this incidence to nil. Generally, these losses are both recognised by the shepherd and easily confirmed by the clinician.

show abstract

D‐lactic acidosis in lambs

Cited by 13 publications

References 9 publications

Clinical use of plasma lactate concentration. Part 1: Physiology, pathophysiology, and measurement

Clinical use of plasma lactate concentration. Part 1: Physiology, pathophysiology, and measurement

Successful correction of D‐lactic acid neurotoxicity (drunken lamb syndrome) by bolus administration of oral sodium bicarbonate

A practical approach to reducing losses due to drunken lamb syndrome

Contact Info

Product

Resources

About