D-dimer plasma measurement in patients undergoing major hip surgery: Use in the prediction and diagnosis of postoperative proximal vein thrombosis

Bongard, O; Wicky, Jacques; Peter, Robin; Simonovska, Snezana; Vogel, Jean-Joseph; Moerloose, Philippe de; Reber, Guido; Bounameaux, Henri

doi:10.1016/0049-3848(94)90269-0

Cited by 61 publications

(33 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A population-based prospective study has demonstrated a strong, positive relationship between D-dimer and development of future VTE (Cushman et al, 2003). Elevated presurgery D-dimer, before development of VTE, has been reported previously in patients undergoing hip surgery (Bongard et al, 1994;CoFrancesco et al, 1997). However D-dimer did not predict for VTE in medical or surgical patients admitted to ICU (Crowther et al, 2005), or in two studies of 71 and 60 ovarian cancer patients undergoing surgery (Olt et al, 1990;von Tempelhoff et al, 1997).…”

Section: Discussionmentioning

confidence: 96%

“…Preoperative D-dimer, prothrombin fragments 1 and 2 (PF1 þ 2) and TAT have been shown to have some value in predicting postoperative VTE in patients undergoing major orthopaedic surgery (Bongard et al, 1994;Ginsberg et al, 1995;Cofrancesco et al, 1997;Lowe et al, 1999); however, markers of hypercoagulability and D-dimer were found to be of no use in predicting VTE in acutely ill medical patients (Crowther et al, 2005). Preoperative PF1 þ 2, TAT and soluble fibrin do not predict postoperative DVT in colorectal cancer patients; however, postoperative (days 1 -7) levels predict DVT, before a clinical diagnosis has been made (Iversen and Thorlacius-Ussing, 2002).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Early changes in the haemostatic and procoagulant systems after chemotherapy for breast cancer

et al. 2008

View full text Add to dashboard Cite

Venous thromboembolism (VTE) following breast cancer chemotherapy is common. Chemotherapy-induced alterations in markers of haemostasis occur during chemotherapy. It is unclear how rapidly this occurs, whether this is upregulated in patients developing VTE and whether changes predict for VTE. Markers of haemostasis, functional clotting assays and vascular endothelial growth factor were measured before chemotherapy and at 24 h, 4 days, 8 days and 3 months following commencement of chemotherapy in early and advanced breast cancer patients and in age-and sex-matched controls. Duplex ultrasound imaging was performed after 1 month or if symptomatic. Of 123 patients, 9.8% developed VTE within 3 months. Activated partial thromboplastin time (APTT), prothrombin time (PT), D-dimer, fibrinogen, platelet count, VEGF and fibrinogen were increased in cancer. Fibrinogen, D-dimer, VEGF and tissue factor were increased, at baseline, in patients subsequently developing VTE. D-dimer of less than 500 ng ml À1 has a negative predictive value of 97%. Activated partial thromboplastin time, PT and thrombin -antithrombin showed significantly different trends, as early as within 24 h, in response to chemotherapy in patients subsequently developing VTE. Markers of coagulation and procoagulants are increased, before chemotherapy, in patients who subsequently develop VTE. A group of patients at minimal risk of VTE can be identified, allowing targeted thrombopropylaxis to the higher risk group.

show abstract

Section: Discussionmentioning

confidence: 96%

mentioning

confidence: 99%

Early changes in the haemostatic and procoagulant systems after chemotherapy for breast cancer

et al. 2008

View full text Add to dashboard Cite

show abstract

“…However, the FDP generation was less evident in patients undergoing hip replacement. Some authors have suggested that FDP levels may be useful for predicting postoperative DVT [32][33][34]. It is unlikely that the observed fibrinolysis differences between both types of surgery could be attributed to changes induced by the different prophylactic dose, since a clear effect of low molecular weight heparin on fibrinolysis has not been demonstrated in vivo [35,36].…”

Section: Discussionmentioning

confidence: 99%

Hemostatic markers in surgery: a different fibrinolytic activity may be of pathophysiological significance in orthopedic versus abdominal surgery

López¹,

*²,

Pardo³

et al. 1998

International Journal of Clinical & Laboratory Research

View full text Add to dashboard Cite

Without prophylaxis, patients subjected to major abdominal surgery have a risk of deep vein thrombosis of approximately 30%, while the rate varies between 40% and 60% in orthopedic surgery. The reasons for this discrepancy are not completely understood. The present study was designed to compare the pre-and postoperative behavior of different coagulation and fibrinolysis parameters in patients undergoing both types of surgery, receiving low molecular weight heparin prophylaxis. Samples were taken before operation and on postoperative days 1,3, and 7. The following parameters were assessed: prothrombin fragment 1+2, thrombin-antithrombin III complexes, fibrinopeptide A, tissue plasminogen activator, plasminogen activator inhibitor, plasmin-c~__-antiplasmin complexes, and fibrin degradation products. We found a significant increase in the clotting markers postoperatively compared with preoperative values (P<0.05), both in abdominal and orthopedic surgery, indicating a marked hemostatic activation which remained until postoperative day 7. A significant increase in plasminogen activator inhibitor (P<0.01) and a decrease in tissue plasminogen activator and plasmin-%-antiplasmin complexes was also observed early

show abstract

“…12 Although a very high sensitivity of D-dimer test is reported in the diagnosis of VTE, its specificity is relatively poor. 1,7,11 In addition, the specificity decreases with increasing age. 13 Therefore, other more specific screening techniques are needed for the efficient prediction of VTE.…”

Section: Introductionmentioning

confidence: 99%

“…The plasma D-dimer level has been frequently used for this purpose and the clinical relevance of D-dimer test for screening postoperative VTE in fracture patients has been reported. [7][8][9][10][11] However, it has been shown that D-dimer values are normal in about 30% of patients with DVT distal to the knee and in 5% of patients with DVT proximal to the knee. 12 Although a very high sensitivity of D-dimer test is reported in the diagnosis of VTE, its specificity is relatively poor.…”

Section: Introductionmentioning

confidence: 99%

Thrombin–antithrombin III complex tests

Lee

Niikura

Igarashi

et al. 2017

J Orthop Surg (Hong Kong)

View full text Add to dashboard Cite

Purpose: Patients with fractures of the pelvis and/or lower extremities are at a high risk of developing postoperative venous thromboembolism (VTE). The purpose of this study was to determine whether the thrombin-antithrombin III complex (TAT) tests could be used for postoperative screening of VTE in patients with lower limb or pelvic fractures. Methods: We enrolled 133 patients who underwent surgical treatment for fracture of the pelvis or lower extremities. TAT and D-dimer levels were compared in patients with and without VTE. Receiver operating characteristic (ROC) curve analysis was done and the appropriate TAT and D-dimer cutoff levels were determined for VTE screening. Results: VTE was diagnosed in 41 patients (30.8%). Patients with VTE had significantly higher levels of TAT and D-dimer on postoperative days 1, 3, and 7 than those without VTE, respectively. ROC curve analysis suggested that TAT test at postoperative day 7 had the highest accuracy for predicting postoperative VTE. With the optimal cutoff TAT level of 3.0 ng/mL, sensitivity and specificity were 93.3% and 70.1%, respectively. With the optimal cutoff D-dimer level of 7.4 mg/mL, sensitivity and specificity were 93.3% and 57.0%, respectively. Conclusion: TAT levels measured at postoperative day 7 could be the most useful parameter for screening postoperative VTE. TAT can be used as a screening tool for screening postoperative VTE in patients with lower limb and pelvic fractures.

show abstract

D-dimer plasma measurement in patients undergoing major hip surgery: Use in the prediction and diagnosis of postoperative proximal vein thrombosis

Cited by 61 publications

References 6 publications

Early changes in the haemostatic and procoagulant systems after chemotherapy for breast cancer

Early changes in the haemostatic and procoagulant systems after chemotherapy for breast cancer

Hemostatic markers in surgery: a different fibrinolytic activity may be of pathophysiological significance in orthopedic versus abdominal surgery

Thrombin–antithrombin III complex tests

Contact Info

Product

Resources

About