D-dimer may predict poor outcomes in patients with aneurysmal subarachnoid hemorrhage: a retrospective study

Liu, Junhui; Li, Xiangkui; Chen, Zhibiao; Cai, Qiang; Wang, Long; Ying-hu, YE; Chen, Qianxue

doi:10.4103/1673-5374.221158

Cited by 18 publications

(10 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All enrolled subjects were categorized into four groups according to their plasma GPR quartile (Q): ( 1 ) Q1 (<32.7), ( 2 ) Q2 (32.7–38.8), ( 3 ) Q3 (38.9–47.2), and ( 4 ) Q4 (>47.2). The patients' characteristics and clinical features are presented according to GPR quartile in Table 2 .…”

Section: Resultsmentioning

confidence: 99%

“…Biomarkers may help clinicians to make therapeutic decisions when considering the severity of aSAH and in being able to predict whether a patient will have a poor prognosis, which may improve outcomes. Numerous biomarkers such as D-dimer, lactate, and C-reactive protein (CRP) have been reported to be the most promising biomarkers in aSAH patients ( 1 , 3 , 4 ). In addition, some clinical studies have reported that hyperglycemia is related with the risk of poor outcome and delayed cerebral ischemia (DCI) after aSAH ( 5 , 6 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association of Plasma Glucose to Potassium Ratio and Mortality After Aneurysmal Subarachnoid Hemorrhage

et al. 2021

View full text Add to dashboard Cite

Objectives: Hyperglycemia and hypokalemia are common problems in patients with aneurysmal subarachnoid hemorrhage (aSAH). The aim of this study was to determine whether the plasma glucose to potassium ratio (GPR) predicts mortality due to aSAH.Methods: We prospectively recruited aSAH patients and healthy controls between March 2007 and May 2017. Clinical outcomes included mortality and poor outcome (modified Rankin scale score of 3-6) after 3 months. Multivariable analysis was used to determine the association between plasma GPR and 3-month mortality in aSAH patients.Results: A total of 553 patients were recruited, and the mortality rate was 11%. The GPR was significantly elevated in aSAH patients compared with controls, in patients with a poor outcome than with a good outcome and in non-survivals than in survivals. Multivariable analysis showed that the plasma GPR was an independent factor associated with 3-month mortality. The area under the curve of the GPR was 0.747 in predicting 3-month mortality.Conclusion: The plasma GPR on admission has potential as a predictor of 3-month mortality in patients with aSAH.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of Plasma Glucose to Potassium Ratio and Mortality After Aneurysmal Subarachnoid Hemorrhage

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Thirteen studies examined the impact of D-dimer levels on poststroke functional outcome (25,26,28,31,33,35,44,49,51).…”

Section: Functional Outcomesmentioning

confidence: 99%

“…Nine studies evaluated the impact of D-dimer levels on poststroke mortality (26)(27)(28)(29)(30)(31)(32)(33)(34). A hazard ratio of 2.29 (95% CI: 1.35-3.88, p = 0.002, Figure 9) was observed, with moderate heterogeneity (I 2 : 39.03%).…”

Section: Mortality Outcomesmentioning

confidence: 99%

See 1 more Smart Citation

A Systematic Review of the Predictive Value of Plasma D-Dimer Levels for Predicting Stroke Outcome

Zhang

Wang

et al. 2021

Front. Neurol.

View full text Add to dashboard Cite

Background: Stroke is a leading cause of morbidity and mortality. Over the past decade, plasma D-dimer levels have emerged as a biomarker for predicting stroke outcome. However, no consensus in the literature currently exists concerning its utility for predicting post-stroke functional outcome and mortality.Objective: To systematically review the effectiveness of plasma D-dimer levels for predicting functional outcome and mortality following stroke.Methods: Five academic databases were screened according to PRISMA guidelines for eligible studies. With these studies, we conducted a random-effect meta-analysis to evaluate the impact of plasma D-dimer levels for predicting functional outcome and mortality post-stroke. We also conducted subgroup analyses to evaluate differences in predictive capacity for different stroke subtypes.Results: Nineteen studies were included, containing data on 5,781 stroke patients (mean age: 65.26 ± 6.4 years). Overall methodological quality for the included studies was high. Meta-analysis showed that increased D-dimer levels were predictive of worsened functional outcomes (Hazard ratio: 2.19, 95% CI: 1.63–2.93) and elevated overall mortality (2.29, 1.35–3.88). Subgroup analysis showed that plasma D-dimer levels were more predictive of poorer functional outcomes for ischemic (2.08, 1.36–3.18) stroke as compared to intracerebral hemorrhage (2.62, 1.65–4.17). We also noted that predictive capacity was similar when it came to mortality in patients with cryptogenic ischemic stroke (2.65, 0.87–8.08) and intracerebral hemorrhage (2.63, 1.50–4.59).Conclusion: The study provides preliminary evidence concerning the capacity of plasma D-dimer levels for predicting functional outcomes and mortality following stroke and reports that higher D-dimer levels of are associated with poorer functional outcomes and higher mortality.

show abstract

Derivation of Coagulation Phenotypes and the Association with Prognosis in Traumatic Brain Injury: A Cluster Analysis of Nationwide Multicenter Study

et al. 2023

View full text Add to dashboard Cite

D-dimer may predict poor outcomes in patients with aneurysmal subarachnoid hemorrhage: a retrospective study

Cited by 18 publications

References 60 publications

Association of Plasma Glucose to Potassium Ratio and Mortality After Aneurysmal Subarachnoid Hemorrhage

Association of Plasma Glucose to Potassium Ratio and Mortality After Aneurysmal Subarachnoid Hemorrhage

A Systematic Review of the Predictive Value of Plasma D-Dimer Levels for Predicting Stroke Outcome

Derivation of Coagulation Phenotypes and the Association with Prognosis in Traumatic Brain Injury: A Cluster Analysis of Nationwide Multicenter Study

Contact Info

Product

Resources

About