D-Dimer as a Potential Prognostic Marker

Nagy, Zsuzsanna; Horváth, Orsolya; Kádas, J.; Valtinyi, Dorottya; László, Larisza; Kopper, Bence; Blaskó, György

doi:10.1007/s12253-011-9493-5

Cited by 26 publications

(18 citation statements)

References 15 publications

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“…Besides, a number of studies have confirmed the predictive value of D-dimer levels for venous thromboembolism (16). This study found that FIB levels were increased in CRC patients, especially in those with T2DM.…”

Section: In Colorectal Cancer Patientssupporting

confidence: 68%

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Influence of type 2 diabetes mellitus on Khorana venous thromboembolism risk in colorectal cancer patients

Wang

Zhao

et al. 2017

Rev Esp Enferm Dig

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Background: Many studies have documented the association between venous thromboembolism (VTE) and colorectal cancer (CRC). The Khorana model is a VTE risk assessment model for predicting cancer-associated thrombosis. Type 2 diabetes (T2DM) has also been reported to increase the risk of VTE.Purpose: The aim of this study was to investigate the influence of T2DM on Khorana VTE risk in CRC patients and to explore the relationship between Khorana VTE category and CRC clinicopathological factors.Methods: This analysis included 615 CRC patients (205 with T2DM). Fibrinogen and D-dimer levels were compared within each group. A comparison was made of the proportion of patients in different Khorana VTE risk categories in CRC patients with and without T2DM. The association between Khorana VTE risk category and clinicopathological factors among all the CRC patients was evaluated.Results: Fibrinogen levels of CRC patients with T2DM were significantly higher than those of non-diabetes patients (4.13 ± 1.06 vs 3.94 ± 0.98, p < 0.001

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Section: In Colorectal Cancer Patientssupporting

confidence: 68%

“…D-dimer is an end-product of FIB and crosslinked fibrin degradation. It appears in the blood as a small peptide fragment after the activation of the fibrinolytic system and also signals the activation of coagulation (16).…”

Section: Discussionmentioning

confidence: 99%

Influence of type 2 diabetes mellitus on Khorana venous thromboembolism risk in colorectal cancer patients

Wang

Zhao

et al. 2017

Rev Esp Enferm Dig

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“…Thus, it could be accepted as a potential prognostic marker. 10,11 The aim of this study was investigation of prognostic value of D-dimer in non-metastatic breast cancer patients without thromboembolism.…”

Section: Introductionmentioning

confidence: 99%

The Prognostic Value of High Pretreatment Plasma D-Dimer Levels in Non-Metastatic Breast Cancer Patients with Absence of Venous Thromboembolism.

Kaçan¹

2016

UHOD

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Systemic activation of coagulation and fibrinolysis is frequently observed in cancer patients without thrombosis. Recent studies have showed the association between D-Dimer (DD) and metastatic spread and prognosis of cancer. We aimed to investigate the prognostic value of DD in patients with non metestatic breast cancer (nMBC) and evaluated the DD levels and other variables for overall survival (OS) using univariate and multivariate analyses in 448 patients. The median follow-up time was 50 months (3-151 months). There was only significant relationship between DD and distant metastases (p= 0.052). Performance status (PS) (p< 0.001 and < 0.001), stage (p< 0.001 and < 0.001) , CEA (p< 0.001 and < 0.001), CA 15-3 (p< 0.001 and < 0.001) and DD (p< 0.001 and 0.034) were determined as prognostic factors for OS in univariate analysis. In multivariate analysis, PS (ECOG 0 vs ECOG 1, p= 0.022; ECOG 0 vs ECOG ≥2, (p< 0.001), stage (stage I vs stage II, p= 0.566; stage I vs stage III, p= 0.033), the CA 15-3 (p= 0.048) and DD levels (p= 0.015) were determined as independent prognostic factors for OS . In conclusion, pretreatment high DD level is an important prognostic factor in patients with non metastatic breast cancer and high DD levels were associated with poor outcome.

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“…There were plenty of articles working on the relation between D-dimer and cancer [11,25]. Han et al demonstrated the significant association between elevated D-dimer concentrations and the possibility of occult cancer in patients with unprovoked venous thromboembolism (VTE) [26].…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of pretreatment D-dimer level in small-cell lung cancer: a meta-analysis

Wang

et al. 2019

Preprint

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Purpose To determine the prognostic significance of pretreatment D-dimer level in predicting clinical outcomes, such as the overall survival (OS) and progression-free survival (PFS), of patients with small cell lung cancer (SCLC). Methods A systematic search in PubMed, Web of Science, EMBASE, Cochrane Library, CNKI, SinoMed, Wanfang and VIP databases was performed to identify available studies. The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were applied to assess the association of pretreatment D-dimer level with prognosis of SCLC patients. All statistical analyses were conducted via the STATA 12.0 version software. Results A total of 7 studies involving 964 patients were included in this meta-analysis and all patients were from China. The results showed that elevated pretreatment D-dimer level was significantly correlated with worse OS(HR=1.90, 95% CI: 1.55-2.34, P <0.001) and PFS (HR=1.52, 95% CI: 1.24-1.85, P ＜0.001). Subgroup analyses based on the treatment, D-dimer cut-off, detection method and source of HR were also performed to further verify the prognostic value of pretreatment D-dimer level in SCLC. Conclusions Pretreatment blood concentration of D-dimer may deserve as a reliable factor to predict prognosis of Chinese patients with SCLC. More well-designed prospective studies with big samples are still needed to verify our findings.

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D-Dimer as a Potential Prognostic Marker

Cited by 26 publications

References 15 publications

Influence of type 2 diabetes mellitus on Khorana venous thromboembolism risk in colorectal cancer patients

Influence of type 2 diabetes mellitus on Khorana venous thromboembolism risk in colorectal cancer patients

The Prognostic Value of High Pretreatment Plasma D-Dimer Levels in Non-Metastatic Breast Cancer Patients with Absence of Venous Thromboembolism.

Prognostic value of pretreatment D-dimer level in small-cell lung cancer: a meta-analysis

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