d-Amphetamine conditioned place preference in developing mice: Relations with changes in activity and stereotypies.

Laviola, Giovanni; Dell’Omo, Giacomo; Chiarotti, Flavia; Bignami, Giorgio

doi:10.1037/0735-7044.108.3.514

Cited by 53 publications

(41 citation statements)

References 42 publications

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“…One model used to ascertain the rewarding properties of drugs in rodents is conditioned place preference (Bardo and Bevins, 2000). The general finding is that drug-induced place preference increases with age (Laviola et al, 1992(Laviola et al, , 1994Tirelli et al, 2003;Schramm-Sapyta et al, 2004); however, there are conflicting reports (Campbell et al, 2000) and many studies do not include younger postweanling animals.…”

Section: Introductionmentioning

confidence: 99%

Trk: A Neuromodulator of Age-Specific Behavioral and Neurochemical Responses to Cocaine in Mice

Niculescu¹,

Perrine²,

Miller³

et al. 2008

J. Neurosci.

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Responses to psychostimulants vary with age, but the molecular etiologies of these differences are largely unknown. The goal of the present research was to identify age-specific behavioral and molecular adaptations to cocaine and to elucidate the mechanisms involved therein. Postweanling, periadolescent, and adult male CD-1 mice were exposed to cocaine (20 mg/kg) for 7 d. The rewarding effects of cocaine were assessed, as were the response to a Trk antagonist and the regulation of dopamine and cAMP-regulated phosphoprotein, 32 kDa (DARPP-32). Cocaine was rewarding in both periadolescent and adult mice using a conditioned place preference procedure. In contrast, postweanling mice failed to demonstrate significant cocaine-induced place preference. Because components of the neurotrophin system including brain-derived neurotrophic factor and TrkB are developmentally regulated, their role in the age-specific effects of cocaine was determined using the Trk receptor antagonist K252a. Postweanling mice that received K252a before daily cocaine showed a significant place preference to the cocaine-paired environment that was not seen in the absence of K252a. DARPP-32 protein levels were significantly upregulated in the lateral region of the caudate-putamen exclusively in postweanling mice after chronic cocaine. Daily pretreatment with K252a attenuated the induction of DARPP-32 in the postweanling striatum. These data indicate that Trk neurotransmission plays a role in age-specific behavioral and molecular responses to cocaine and concurrently modulates DARPP-32 levels.

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Section: Introductionmentioning

confidence: 99%

Trk: A Neuromodulator of Age-Specific Behavioral and Neurochemical Responses to Cocaine in Mice

Niculescu¹,

Perrine²,

Miller³

et al. 2008

J. Neurosci.

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“…Amphetamine induced hyperactivity in mice emerges at weanling [80]. Interestingly, direct administration of MDMA, or amphetamine, to the chicken embryo five days prior to hatching induced an acute reduction in motility [13].…”

Section: Behavioralmentioning

confidence: 99%

A developmental comparison of the neurobehavioral effects of ecstasy (MDMA)

Piper

2007

Neurotoxicology and Teratology

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The entactogen ±3,4-methylenedioxymethamphetamine (MDMA or ecstasy) is a popular recreational drug among college, high school, and, occasionally, middle school students. Preclinical research examining the acute and long-term effects of MDMA has predominately been conducted in reproductively mature subjects but there has been increasing interest in adolescent and in utero exposure. This review examines the acute and long-term responses to MDMA during perinatal, adolescent, and adult periods. The ability of MDMA to alter core body temperature emerges gradually during ontogeny while a reduction in body weight is evident at all ages. Learning and workingmemory are also altered independent of the developmental stage of exposure. Current evidence suggests adults are more sensitive to the long-term serotonin depletions following MDMA but younger ages also exhibit substantial and rapid neuroplasticity. Sexually dimorphic MDMA responses have been identified for the acute hyperthermic and motoric effects of MDMA with pubescent males being especially susceptible. Several physiological, behavioral, and neurochemical MDMA issues requiring further study are also outlined. Keywords±3; 4-methylenedioxymethamphetamine; Adolescence; Anxiety; Depression; Learning; SerotoninThe phenylethylamine ±3,4-methylenedioxymethamphetamine (MDMA) is a popular recreational drug best known as ecstasy. MDMA has several other street names including Adam, baby slits, chocolate chips, clarity, doctor, essence, kleenex, and roll [77]. Although ecstasy has some similarities with both stimulants and hallucinogens, MDMA is an entactogen. Entactogen means "touching within" based on the drug's subjective effects [110]. MDMA also causes long term changes in several markers of the integrity of the serotonin (5-HT) neurotransmitter system [58]. There have been several excellent recent reviews on MDMA toxicology, pharmacokinetics, pharmacodynamics, and neurobehavioral consequences [30,37,113,157], but none have systematically addressed the intricate effects of MDMA during development.Ecstasy use is not restricted to limited subpopulations, that is fans of techno music and "raves" [173] or male homosexuals [73,81], as MDMA has expanded into the general population [124,148,170] and especially young people [52,78,170,172]. Over one hundred pregnant women in Toronto called a substance abuse helpline between 1998 and 2000 to inquire Corresponding Author: Brian J. Piper, Neuroscience and Behavior Program, University of Massachusetts, Amherst, MA 01003-7710, Tel: (413) 545-0996, bpiper@nsm.umass.edu Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers...

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“…In the first of these studies (103), males at 4 weeks of age dearly showed the change in amphetamine reactivity but females did not; this is of considerable interest in the light of the growing evidence on early sex dimorphism of monoaminergic regulatory systems (79). Moreover, the same study achieved a separation of the effects of ethanol from those of an important confounding variable by the use of a yoked control group that received sucrose substituted isocalorically for ethanol.…”

Section: Methylmercury (Mm) As Early Asmentioning

confidence: 85%

“…If responses are scored during the test, no more than three to four of them should be included in the protocol to minimize the risk of observer errors; the suggestion is to focus the attention on locomotion, rearing, grooming, and stereotypies that can reveal noxious effects of the treatment under study or must be scored as part of a pharmacological reactivity assessment [see Laviola et al (79) (80).…”

Section: Open Fieldmentioning

confidence: 99%