D

Crystal Structure of the Ergothioneine Sulfoxide Synthase from Candidatus Chloracidobacterium thermophilum and Structure-Guided Engineering To Modulate Its Substrate Selectivity

“…[1][2][3][4] In addition, a combination of the two most abundant natural thiols (E 0 ′ = − 0.06 V [5][6][7] for ergothioneine and E 0 ′ = − 0.24 V 8 for glutathione) protect cells against reactive oxygen species (ROS) and reactive nitrogen species (RNS) under varying conditions. 9 Ergothioneine has also been suggested to serve as a protecting agent against several diseases, including cardiovascular disorders, 10 rheumatoid arthritis, 11,12 Crohn's disease, 13,14 neurodegenerative diseases, [15][16][17][18] and diabetes. 19 Because of its potential health benefit, ergothioneine biosynthetic studies have received considerable interest in recent years.…”