Czech Working Group for Paediatric Gastroenterology and Nutrition guidelines for diagnostics and treatment of inflammatory bowel diseases in children – 1st edition update

Bronský, Jiří; Beránková, Katarína; Černá, Zuzana; Copova, Ivana; Durilová, Marianna; Hradský, Ondřej; Karásková, Eva; Mitrová, Katarína; Nevoral, Jiří; Poš, Lucie; Schwarz, Jan; Szitányi, Peter; Škába, Richard; Šuláková, A.; Tuková, Jana

doi:10.14735/amgh201711

Cited by 2 publications

(1 citation statement)

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“…We then undertook to create a candidate model for predicting early relapse of the disease. Patients received initial standardized treatment with mesalazine and/or corticosteroids guided by the PUCAI according to relevant national guidelines [ 17 ] and were evaluated for adherence to therapy by use of structured interview. We monitored whether after standard treatment a patient experienced an early relapse during the first year of treatment despite significant initial remission of the disease, defined as PUCAI < 10 during the first 3 months after diagnosis and fecal calprotectin <100 ug/L.…”

Section: Methodsmentioning

confidence: 99%

MicroRNAs in Colon Tissue of Pediatric Ulcerative Pancolitis Patients Allow Detection and Prognostic Stratification

Jabandžiev

Kakisaka

Bohošová

et al. 2021

JCM

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Prevalence of inflammatory bowel disease has been on the rise in recent years, especially in pediatric populations. This study aimed to provide precise identification and stratification of pediatric patients with diagnosed ulcerative colitis (UC) according to the severity of their condition and the prediction for standard treatment according to the specific expression of candidate miRNAs. We enrolled consecutive, therapeutically naïve, pediatric UC patients with confirmed pancolitis. We examined formalin-fixed paraffin-embedded specimens of colonic tissue for the expression of 10 selected candidate miRNAs. We performed receiver operating characteristic curve analysis, using area under the curve and a logistic regression model to evaluate the diagnostic and predictive power of the miRNA panels. Sixty patients were included in the final analysis. As a control group, 18 children without macroscopic and microscopic signs of inflammatory bowel disease were examined. The combination of three candidate miRNAs (let-7i-5p, miR-223-3p and miR-4284) enabled accurate detection of pediatric UC patients and controls. A panel of four candidate miRNAs (miR-375-3p, miR-146a-5p, miR-223-3p and miR-200b-3p) was associated with severity of UC in pediatric patients and a combination of three miRNAs (miR-21-5p, miR-192-5p and miR-194-5p) was associated with early relapse of the disease. Nine patients out of the total were diagnosed with primary sclerosing cholangitis (PSC) simultaneously with ulcerative colitis. A panel of 6 candidate miRNAs (miR-142-3p, miR-146a-5p, miR-223-3p, let-7i-5p, miR-192-5p and miR-194-5p) identified those patients with PSC. Specific combinations of miRNAs are promising tools for potential use in precise disease identification and severity and prognostic stratification in pediatric patients with ulcerative pancolitis.

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Section: Methodsmentioning

confidence: 99%