Importance of Hepcidin in the Etiopathogenesis of Anemia in Inflammatory Bowel Disease

Karásková, Eva; Pospı́šilová, Dagmar; Velganova-Veghova, Maria; Geryk, Miloš; Volejnikova, Jana; Holub, Dušan; Hajdúch, Marián

doi:10.1007/s10620-020-06652-1

Cited by 4 publications

(7 citation statements)

References 44 publications

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“…Further, the complement system has emerged as an attractive target for early and upstream intervention in inflammatory diseases [ 33 ]. In addition, there is evidence that anemia decreases immune function and induces inflammatory response [ 34 ]. Based on the above findings, we speculated that the complement system may affect hematopoietic function by regulating immunity and inflammation.…”

Section: Discussionmentioning

confidence: 99%

TMT-based proteomics analysis of the blood enriching mechanism of the total Tannins of Gei Herba in mice

Mu,

Duan,

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

TMT-based proteomics analysis of the blood enriching mechanism of the total Tannins of Gei Herba in mice

Mu,

Duan,

et al. 2024

Heliyon

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“…IBD can be associated with both IDA and anemia of chronic disease (ACD), also known as anemia of inflammation (Karaskova et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…a) Forest plot shows the weighted mean difference (WMD) in serum hepcidin concentrations between participants with IBD and healthy control participants. (b) Forest plot show the standardized mean difference (SMD) in serum prohepcidin concentrations between participants with IBD and healthy control participants.arises from inflammatory conditions whereby the IL-6-hepcidin axis is triggered, leading to low serum iron levels but maintaining sufficient iron stores(Camaschella et al, 2019;Karaskova et al, 2021; …”

mentioning

confidence: 99%

Association between hepcidin levels and inflammatory bowel disease: A systematic review and meta‐analysis of observational studies

Soltanieh,

Salavatizadeh,

Gaman

et al. 2024

Food Science & Nutrition

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Hepcidin has a crucial role in iron homeostasis upon inflammatory conditions such as inflammatory bowel disease (IBD). Thus, we conducted a systematic review and meta‐analysis to determine the overall association between serum hepcidin concentrations and IBD. Based on the preferred reporting items for systematic review and meta‐analysis (PRISMA) protocols, an electronic literature search was conducted on PubMed/MEDLINE, Scopus, and Web of Science until June 2020. Studies were deemed eligible for inclusion if they met the following criteria: (1) diagnosis of IBD, (2) observational design, and (3) measured serum hepcidin and prohepcidin concentrations in IBD patients and control group. Overall, 10 studies including 1184 participants were evaluated. Random‐effects meta‐analysis revealed that subjects with IBD had 7.22 ng/mL (95% CI: 2.10, 12.34; p = .006) higher serum hepcidin concentrations compared to control groups. A nonsignificantly lower serum prohepcidin concentration (0.522 ng/mL, 95% CI: −1.983 to 0.939; p = .484) was found for IBD patients compared to healthy subjects. However, there was significant heterogeneity among the studies regarding both hepcidin (I2 = 98%, p < .001) and prohepcidin levels (I2 = 96%, p < .001), respectively. In an age‐based subgroup analysis, patients aged ≥18 years with IBD displayed higher serum hepcidin levels when compared to healthy individuals (22.36 ng/mL, 95% CI, 2.12–42.61; p = .030). Hepcidin concentrations are elevated in subjects with IBD; however, the clinical relevance of this finding requires further evaluation in future investigations as the increase is relatively small compared to the wide range of normal hepcidin values.

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“…It is indispensable for the metabolism of many substances in the body [ (Dutt et al, 2022); (Stallhofer et al, 2022)]. Iron in the digestive tract is mainly absorbed in the duodenum and upper jejunum in the form of Fe 2+ (Karaskova et al, 2021). Then, in the epithelial cells of small intestinal mucosa, Fe 2+ is oxidized to Fe 3+ , and part of Fe 3+ in the blood is further bound to the transported by transferrin (TF) and receptor (TFR) on the cell membrane and transported into the cell [ (Piskin et al, 2022); (Zhao et al, 2022)], which reacts with the metal reductase Six-transmembrane epithelial antigen of prostate 3 (STEAP3) in the endoplasmic reticulum to form Fe 2+ ; Fe 2+ is transported to cells through transferrin receptor protein 1 (TFR1).…”

Section: Iron Metabolism Affects the Ferroptosismentioning

confidence: 99%

Recent advances in ferroptosis and therapeutic strategies for glioblastoma

Lü²,

Zhang³

et al. 2023

Front. Mol. Biosci.

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Ferroptosis is an emerging form of cell death characterized by the over-accumulation of iron-dependent lipid peroxidation. Ferroptosis directly or indirectly disturbs glutathione peroxidases cycle through diverse pathways, impacting the cellular antioxidant capacities, aggravating accumulation of reactive oxygen species in lipid, and it finally causes oxidative overload and cell death. Ferroptosis plays a significant role in the pathophysiological processes of many diseases. Glioblastoma is one of the most common primary malignant brain tumors in the central nervous system in adults. Although there are many treatment plans for it, such as surgical resection, radiotherapy, and chemotherapy, they are currently ineffective and the recurrent rate is almost up to 100%. The therapies abovementioned have a strong relationship with ferroptosis at the cellular and molecular level according to the results reported by numerous researchers. The regulation of ferroptosis can significantly determine the outcome of the cells of glioblastoma. Thus ferroptosis, as a regulated form of programed cell death, has the possibility for treating glioblastoma.

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Importance of Hepcidin in the Etiopathogenesis of Anemia in Inflammatory Bowel Disease

Cited by 4 publications

References 44 publications

TMT-based proteomics analysis of the blood enriching mechanism of the total Tannins of Gei Herba in mice

TMT-based proteomics analysis of the blood enriching mechanism of the total Tannins of Gei Herba in mice

Association between hepcidin levels and inflammatory bowel disease: A systematic review and meta‐analysis of observational studies

Recent advances in ferroptosis and therapeutic strategies for glioblastoma

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