Cytotoxicity Studies of Triterpenoids From Akebia Trifoliata and Clematis Ligusticifolia

Pawar, Rahul S.; Balachandran, P; Pasco, David S.; Khan, Ismail

doi:10.17660/actahortic.2006.720.16

Cited by 4 publications

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“…Out of many triterpenoids, ursolic and oleanolic acids have been studied in detail for their cytotoxic activities such as inhibition of tumor genesis, tumor promotion, angiogenesis [30], ultraviolet-B (UVB) radiation photocarcinogenesis [31], induction of tumor cell differentiation, invasion of tumor cells, metastasis [30] and effect on acute myeloid leukemia [32]. The recent isolation of cytotoxic triterpenoids from Akebla trifoliate and Clematis lingustifolia [33] and cytotoxic triterpenoid saponins from Quillaja saponaria Molina (soap tree) [34] prompted us to undertake a detailed chemical investigation of T. arjuna bark, which resulted in the isolation and characterization of two triterpenic acids arjunic acid (1) and arjungenin (2) and two saponins, arjunetin (3) and arjunglucoside (4), respectively.…”

Section: Resultsmentioning

confidence: 99%

Cytotoxic Agents from Terminalia arjuna

et al. 2007

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Although a number of chemicals have been isolated from Terminalia arjuna, only a few have been evaluated for their biological significance. As a part of our drug discovery programme for cytotoxic agents from Indian medicinal plants, four novel cytotoxic agents arjunic acid (1), arjungenin (2), arjunetin (3) and arjunoglucoside I (4) were isolated from the bark of T. ARJUNA. Out of the four compounds, arjunic acid (1) was significantly active against the human oral (KB), ovarian (PA 1) and liver (HepG-2 & WRL-68) cancer cell lines. Further, the most active compound arjunic acid was converted into seven semi-synthetic ester derivatives 5 - 11. 2-O-Palmitoyl arjunic acid (6) showed two times more activity, while 2, 3-di-O-acetyl-, 2-O-p-anisoyl-, 2, 3-di-O-benzoyl- and 2, 3-di-O-p-nitrobenzoyl arjunic acid (7 - 10) showed 1.7 - 2.3 times less activity than the cytotoxic drug vinblastine against the liver cancer cell lines HepG-2 and WRL-68 respectively.

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