Cytotoxic Agents from <i>Terminalia arjuna</i>

Saxena, Mithlesh; Faridi, Uzma; Mishra, Rupal; Gupta, Madan M.; Darokar, Mahendra P.; Srivastava, Shruti; Singh, Digvijai; Luqman, Suaib; Khanuja, S. P. S.

doi:10.1055/s-2007-990258

Cited by 45 publications

(29 citation statements)

References 13 publications

(15 reference statements)

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“…We present evidence for LDH-A inhibitory properties of a number of commonly used herbs and spices with previously reported anti-cancer properties including bladderwrack [40], kelp [41], cinnamon [42], cats claw bark [43], arjun [44], polygonum multiflorum [45] and witch hazel [46]. Future research will be required to evaluate if LDH-A inhibition is a contributing factor to tumoricidal or anti-proliferative properties of these herbs on diverse human cancer cells.…”

Section: Discussionmentioning

confidence: 99%

High-Throughput Screening to Identify Plant Derived Human LDH-A Inhibitors

Deiab

Mazzio

Messeha

et al. 2013

EJMP

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Aims-Lactate dehydrogenase (LDH)-A is highly expressed in diverse human malignant tumors, parallel to aggressive metastatic disease, resistance to radiation/chemotherapy and clinically poor outcome. Although this enzyme constitutes a plausible target in treatment of advanced cancer, there are few known LDH-A inhibitors.Study Design-In this work, we utilized a high-throughput enzyme micro-array format to screen and evaluate > 900 commonly used medicinal plant extracts (0.00001-.5 mg/ml) for capacity to inhibit activity of recombinant full length human LDHA; EC .1.1.1.27.Methodology-The protein sequence of purified enzyme was confirmed using 1D gel electrophoresis-MALDI-TOF-MS/MS, enzyme activity was validated by oxidation of NADH (500μM) and kinetic inhibition established in the presence of a known inhibitor (Oxalic Acid). Conclusion-These findings reflect relative potency by rank of commonly used herbs and plants that contain human LDH-A inhibitory properties. Future research will be required to isolate chemical constituents within these plants responsible for LDH-A inhibition and investigate potential therapeutic application. Results-Of

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Section: Discussionmentioning

confidence: 99%

High-Throughput Screening to Identify Plant Derived Human LDH-A Inhibitors

Deiab

Mazzio

Messeha

et al. 2013

EJMP

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“…Arjunic acid was converted into seven semi-synthetic ester derivatives. 2-O-Palmitoyl arjunic acid showed two times more activity, while 2, 3-di-O-acetyl-, 2-O-p-anisoyl-, 2, 3-di-O-benzoyl and 2, 3-di-O-p-nitrobenzoyl arjunic acid showed 1.7-2.3 times less activity than the cytotoxic drug vinblastine against the liver cancer cell lines HepG-2 and WRL-68, respectively (Saxena et al 2007). …”

Section: Anticancer Effectmentioning

confidence: 92%

“…The cancer cell growth inhibitory constituents mainly resides in Kandil and Narsar (1998) the bark, stem and leaves of the Mauritius medicinal plant T. arjuna. Tannins and flavones were reported to be mainly responsible for anticancer activity (Saxena et al 2007). …”

Section: Anticancer Effectmentioning

confidence: 99%

Terminalia arjuna a sacred medicinal plant: phytochemical and pharmacological profile

Jain¹,

Yadav

Gill

et al. 2009

Phytochem Rev

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Terminalia arjuna Wight & Arn. (Combretaceae) is a tree having an extensive medicinal potential. The plant is used traditionally in the treatment of various aliments. T. arjuna is a very good hypocholsteremic, hypolipidemic, anticoagulant, antihypertensive, antithrombotic, antiviral, antifungal and antibacterial agent Various parts of plant have been investigated for the presence of phytoconstituents and pharmacological activities. Many useful phytoconstituents have been isolated from T. arjuna. Triterpenoids are mainly responsible for cardiovascular properties. Tannins and flavonoids are responsible for its anticancer properties. The present review summarizes the ethnic use, pharmacological activities of the extracts and phytoconstituents of T. arjuna for last 90 years.

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“…[5][6][7][8] The active components and their modes of actions have also been reJeksy Jos Manalil, Indu Muraleedharan Suseela, Smitha Koyickalmadhom Ramavarma, Arunaksharan Narayanankutty and Achuthan Chathrattil Raghavamenon ported. [9][10][11][12] The individual plant powders of the formulation and the formulation itself in different proportions were tested using various in vitro and in vivo models and are found to have antioxidant, antithrombotic, anti-inflammatory and anti-lipidemic efficacy. The standardisation of the most active formulation GSTC3 was then the next step to be done together with testing for uniqueness in batch to batch preparation.…”

Section: Introductionmentioning

confidence: 99%

Component Authentication and Standardisation of an Anti-atherosclerotic Herbal Formulation-GSTC3

Manalil¹,

Suseela²,

Ramavarma³

et al. 2015

Phcog J

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Context: Polyherbal drugs in traditional medicine have been time-tested for treatment of a wide variety of chronic ailments. Aims: To determine constituent components in an in-house designed polyherbal formulation GSTC3 and evaluation of consistency in preparation. Settings and Design: In this study, a hypolipidemic formulation was created using well known plant extracts such as Commiphora mukul (Hook. ex Stocks.) Eng. (Burseraceae), Salacia reticulata Wight (Celastraceae), Terminalia arjuna (Roxb.) Wight and Arn (Combretaceae) and Curcuma longa Linn (Zingiberaceae). Methods and Material:The authentication of individual plant powders was performed using techniques such as powder microscopy and characterised according to Ayurvedic pharmacopeia of India. Phytochemical screening, HPTLC analysis and physicochemical parameters were also determined. Results:The powder microscopic analysis of the individual components served as an authentication for source of plants used. Phytochemical screening ascertained that active classes of compounds reported in the individual extracts such as steroids, terpenoids and polyphenols came into the formulation. Finally, HPTLC analysis of three different batches of GSTC3 ensured stability and integrity in batch to batch preparations. Conclusion: Experimental studies have revealed the antioxidant, antiinflammatory, anti-lipidemic and anti-thrombotic efficacy of GSTC3. This standardisation procedure is essential for further development of GSTC3 into an efficient anti-atherosclerotic drug candidate.Key words: HPTLC, Pharmacognosy, Polyherbal formulation, Powder microscopy, Phytochemical screening. SUMMARY• GSTC is an anti-atherosclerotic polyherbal formulation developed from four individual medicinal plants.• Powder microscopic analysis of the individual components of GSTC3 served as an authentication of source plant.• Phytochemical screening ascertained the presence of steroids, terpenoids and polyphenols in the formulation.• HPTLC analysis of three different batches of GSTC3 ensured stability and integrity among batch to batch preparations.• Physicochemical analysis showed the feasibility of GSTC3 in its further development as an efficient anti-atherosclerotic drug candidate.

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Cytotoxic Agents from Terminalia arjuna

Cited by 45 publications

References 13 publications

High-Throughput Screening to Identify Plant Derived Human LDH-A Inhibitors

High-Throughput Screening to Identify Plant Derived Human LDH-A Inhibitors

Terminalia arjuna a sacred medicinal plant: phytochemical and pharmacological profile

Component Authentication and Standardisation of an Anti-atherosclerotic Herbal Formulation-GSTC3

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