“…PMNs also interact with other cells of the innate and adaptive immune system [3,33], and they can, e.g., inhibit the proliferation and activation of T cells by arginine depletion via PMN arginase I [12,34,35] or H 2 O 2 secretion [36,37]. Whereas our data show clear differences in arginine dependence of PMN versus T cells [12] or NK cells [21], there are also common themes: cellular viability, cytokine and chemokine mRNA induction, IL-8 protein synthesis, as well as cytotoxicity and chemotaxis are unimpaired in the absence of arginine in T cells [14,38] and in PMN (this manuscript). Finally, our results are relevant for the therapeutic use of novel, arginine-depleting, metabolic anti-tumor strategies [16].…”