Cytotoxicity of New Ferulic-Acid Derivatives on Human Colon Carcinoma (HCT116) Cells

Bakholdina, L. A.; Markova, Alina A.; Khlebnikov, Аndrei I.; Sevodin, V. P.

doi:10.1007/s11094-019-02030-y

Cited by 2 publications

(5 citation statements)

References 13 publications

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“…[96,97] Benzyl and phenylethyl esters Anticancer. [29] Benzylamino, and carbamyl -amyloid aggregation inhibition, antioxidant, AChE inhibition. [105] Cyclized Antiviral.…”

Section: -N-butylphthalide + Glucosementioning

confidence: 99%

“…Thus, it is not surprising that many efforts have been devoted to the development of FA derivatives [21,27,29,. Some of their relevant structural modifications and properties are summarized in Table 1.…”

Section: Estermentioning

confidence: 99%

“…It is a versatile molecule. There are numerous reports on its antioxidant activity [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ] as well as on its anti-inflammatory [ 15 , 16 ], antibacterial [ 17 , 18 , 19 , 20 ], antiviral [ 21 ], anti-thrombotic [ 22 , 23 ], anti-ageing [ 24 , 25 , 26 ], and antitumoral effects [ 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 ]. It also acts as a cardio protector [ 42 , 43 , 44 , 45 , 46 , 47 , 48 ], neuroprotector [ 49 , 50 , 51 , 52 ,…”

Section: Introductionmentioning

confidence: 99%

“…Thus, it is not surprising that many efforts have been devoted to the development of FA derivatives [ 21 , 27 , 29 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 ]. Some of their relevant structural modifications and properties are summarized in Table 1 .…”

Section: Introductionmentioning

confidence: 99%

“…It is a versatile molecule. There are numerous reports on its antioxidant activity [2][3][4][5][6][7][8][9][10][11][12][13][14] as well as on its anti-inflammatory [15,16], antibacterial [17][18][19][20], antiviral [21], anti-thrombotic [22,23], anti-ageing [24][25][26], and antitumoral effects [27][28][29][30][31][32][33][34][35][36][37][38][39][40][41]. It also acts as a cardio protector [42][43][44][45][46][47][48], neuroprotector [49][50][51]…”

Section: Introductionmentioning

confidence: 99%

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Rational Design of Multifunctional Ferulic Acid Derivatives Aimed for Alzheimer’s and Parkinson’s Diseases

et al. 2023

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Ferulic acid has numerous beneficial effects on human health, which are frequently attributed to its antioxidant behavior. In this report, many of them are reviewed, and 185 new ferulic acid derivatives are computationally designed using the CADMA-Chem protocol. Consequently, their chemical space was sampled and evaluated. To that purpose, selection and elimination scores were used, which are built from a set of descriptors accounting for ADME properties, toxicity, and synthetic accessibility. After the first screening, 12 derivatives were selected and further investigated. Their potential role as antioxidants was predicted from reactivity indexes directly related to the formal hydrogen atom transfer and the single electron transfer mechanisms. The best performing molecules were identified by comparisons with the parent molecule and two references: Trolox and α-tocopherol. Their potential as polygenic neuroprotectors was investigated through the interactions with enzymes directly related to the etiologies of Parkinson’s and Alzheimer’s diseases. These enzymes are acetylcholinesterase, catechol-O-methyltransferase, and monoamine oxidase B. Based on the obtained results, the most promising candidates (FA-26, FA-118, and FA-138) are proposed as multifunctional antioxidants with potential neuroprotective effects. The findings derived from this investigation are encouraging and might promote further investigations on these molecules.

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“…[96,97] Benzyl and phenylethyl esters Anticancer. [29] Benzylamino, and carbamyl -amyloid aggregation inhibition, antioxidant, AChE inhibition. [105] Cyclized Antiviral.…”

Section: -N-butylphthalide + Glucosementioning

confidence: 99%

Section: Estermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Rational Design of Multifunctional Ferulic Acid Derivatives Aimed for Alzheimer’s and Parkinson’s Diseases

et al. 2023

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Rational Design of Multifunctional Ferulic Acid Derivatives Aimed for Alzheimer’s and Parkinson’s diseases

Guzmán‐López¹,

Reina²,

Hernández‐Ayala³

et al. 2023

Preprint

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Ferulic acid has numerous beneficial effects for human health, which are frequently attributed to its antioxidant behavior. In this report many of them are reviewed and 185 new ferulic acid derivatives are computationally designed, using the CADMA-Chem protocol. For the later, the chemical space was sampled and evaluated. To that purpose selection and elimination scores were used, which are built from a set of descriptors accounting for ADME properties, toxicity, and synthetic accessibility. After the first screening, 12 derivatives were selected and further investigated. Their potential role as antioxidants was predicted from reactivity indexes, directed related with the formal hydrogen atom transfer and the single electron transfer mechanisms. The best performing molecules were identified by comparisons with the parent molecule and two references: Trolox and alpha-tocopherol. Their potential as polygenic neuroprotectors was investigated through the interactions with enzymes directed related with the etiologies of Parkinson’s and Alzheimer’s diseases. They are acetylcholinesterase, catechol-O-methyltransferase, and monoamine oxidase B. Based on the obtained results, the most promising candidates (FA-26, FA-118, and FA-138) are proposed as multifunctional antioxidants with potential neuroprotective effects. The findings derived from this investigation are encouraging and might promote further investigations on these molecules.

show abstract

Cytotoxicity of New Ferulic-Acid Derivatives on Human Colon Carcinoma (HCT116) Cells

Cited by 2 publications

References 13 publications

Rational Design of Multifunctional Ferulic Acid Derivatives Aimed for Alzheimer’s and Parkinson’s Diseases

Rational Design of Multifunctional Ferulic Acid Derivatives Aimed for Alzheimer’s and Parkinson’s Diseases

Rational Design of Multifunctional Ferulic Acid Derivatives Aimed for Alzheimer’s and Parkinson’s diseases

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